CAS: 178979-85-6; Capravirine

上下游产品

{5-[(3,5-二氯苯基)硫基]-4-异丙基-1-(4-吡啶基甲基)-1H-咪唑-2-基}甲醇 2-Hydroxymethyl-5-(3,5-Dichlorophenylthio)-4-Isopropyl-1-(Pyridin-4-yl)Methyl-1H-Imidazole 178981-89-0
2-Carbamoyloxymethyl-4-Isopropyl-1-(Pyridin-4-yl)Methyl-1H-Imidazole 209743-76-0

📜2-Carbamoyloxymethyl-4-Isopropyl-1-(Pyridin-4-yl)Methyl-1H-Imidazole,3,5-Dichlorobenzenesulfenyl Chloride置于三乙胺体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 0.5H,以61%的收率获得2-氨基甲酰氧基甲基-5-(3,5-二氯苯基硫代)-4-异丙基-1-(吡啶-4-基)甲基-1H-咪唑
参考文献:Process For Producing Arylsulfenyl Halide
标题:Process For Producing Arylsulfenyl Halide
摘要:一种用于制备化合物的过程,其化学式为(II):其中hal1代表卤素,R1和r2分别独立地代表卤素,烷基,烷氧基,硝基或氰基,包括允许卤化剂与化合物的反应的方法,该化合物的化学式为(I):其中alk代表支链烷基,R1和r2如上定义.

专利信息

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

专利号:US-2007275953-A1
优先权日:2003-09-22
标题:2-Pyridinone Derivatives, Having Hiv Inhibiting Properties
发明人：LE VAN KIET; GEORGES RENOIT; HEYESI LASZLO; CAUVIN CHRISTINE; BOLAND SANDRA; DURANT FRANCOIS; DEMONTE DOMINIQUE; VAN LINT CHRIS; BURNY ARTHU; BOLLEN ALEX; JACQUET ALAIN; DE WALQUE STEPHAINE
权利人:UNIV NOTRE DAME DE LA PAIX; UNIV BRUXELLES
摘要:The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in the treatment of Acquired Immune Deficiency Syndrome (AIDS). The present invention further relates to the synthesis of said compounds and their use, with or without other pharmaceutical agents, in the treatment of AIDS and viral infections by HIV-1.

专利号:US-2007099915-A1
优先权日:2005-10-07
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS R; JOHNSON TED W; PLEWE MICHAEL B; TANIS STEVEN P; ZHU HUICHUN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-2009170846-A1
优先权日:2005-10-03
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS RUPRECHT; PLEWE MICHAEL BRUNO; JOHNSON TED WILLIAM; TANIS STEVEN PAUL; TRAN KHANH TUAN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus “HIVâ€? integrase enzyme. Formula (I).

专利号:EP-1873155-A1
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; ZHU HUICHUN; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I),n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus ('HIV') integrase enzyme.