CAS: 16611-84-0; 2-Hydroxy-6-Pentadecylbenzoic Acid

该化合物是一种天然产生的脂肪酸,产自腰果,具有很强的抗菌和抗硫酸特性,成为制药和生物技术应用的宝贵化合物,其独特结构有助于有效防治病原体,而其天然来源确保了最低的毒性. 氨酸还因其在调制免疫反应和作为生物活性化合物前体方面的潜力而得到承认.

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上下游产品

CAS号103904-74-1 2-(14-hydroxype... | CAS号103904-73-0 Anacardic Acid ... | CAS号38449-25-1 2-methoxy-6-pen... | CAS号38449-27-3 methyl 2-hydrox... | CAS号217449-10-0 ethyl 6-pentade... | CAS号110202-79-4 ethyl 2-methoxy... | CAS号110202-78-3 (2-ethoxycarbon... | CAS号81625-30-1 2-(ethoxycarbon... | CAS号110202-81-8 ethyl 2-methoxy... | CAS号22910-60-7 银杏酸C15:1 | CAS号501-24-6 3-十五烷基苯酚 | CAS号35151-93-0 2-(hydroxymethy... | CAS号65446-29-9 methyl 2-methox... | CAS号38449-27-3 methyl 2-hydrox... | CAS号79688-36-1 2-hydroxy-6-pen... | CAS号79688-37-2 2-hydroxy-6-pen... | CAS号485386-83-2 2-ethoxy-6-pent... | CAS号38449-25-1 2-methoxy-6-pen... | CAS号52122-74-4 acetic acid,3-p...

合成工艺路线路线简述

    📜溴代十五烷置于六甲基磷酰三胺,Sodium Hydroxide,正丁基锂,Diiron Nonacarbonyl,盐酸羟胺,水体系中,用 乙醇,水,苯 用作溶剂,化学反应 4.67H,反应生成氢化白果酸
    参考文献:Synthesis Of Anacardic Acids Utilizing An Annelation Reaction Of Isoxazoles With Ethyl Acetoacetate.
    标题:Synthesis Of Anacardic Acids Utilizing An Annelation Reaction Of Isoxazoles With Ethyl Acetoacetate.
    摘要:腰果酚酸,即6-十五烷基水杨酸(1)和6-[8(Z)-十五烯基]水杨酸(2),通过与乙酰乙酸乙酯的环化反应从异恶唑合成得到.
    Doi:10.1248/cpb.46.1501

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    主要参考文献


    1: da Silva DPB, Florentino IF, da Silva Moreira LK, Brito AF, Carvalho VV, Rodrigues MF, Vasconcelos GA, Vaz BG, Pereira-Junior MA, Fernandes KF, Costa EA. Chemical characterization and pharmacological assessment of polysaccharide free, standardized cashew gum extract (Anacardium occidentale L.). J Ethnopharmacol. 2017 Nov 21;213:395-402. doi: 10.1016/j.jep.2017.11.021. [Epub ahead of print] doi: 10.1016/j.taap.2017.10.011. Epub 2017 Oct 17. doi: 10.1016/j.foodchem.2017.07.146. Epub 2017 Jul 27. doi: 10.1016/j.neo.2017.08.004. Epub 2017 Sep 15.
    8: Schultz DJ, Muluhngwi P, Alizadeh-Rad N, Green MA, Rouchka EC, Waigel SJ, Klinge CM. Genome-wide miRNA response to anacardic acid in breast cancer cells. PLoS One. 2017 Sep 8;12(9):e0184471. doi: 10.1371/journal.pone.0184471. eCollection 2017.
    9: Prinsloo G, Marokane CK, Street RA. Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. J Ethnopharmacol. 2018 Jan 10;210:133-155. doi: 10.1016/j.jep.2017.08.005. Epub 2017 Aug 12. Review. doi: 10.3892/or.2017.5841. Epub 2017 Jul 20.

    合成参考文献

    参考DOI号:10.1039/c8cc05595e
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