CAS: 16420-13-6; Dimethylthiocarbamoylchloride

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CAS号137-26-8 二硫化四甲基秋兰姆 | CAS号758-16-7 二甲基硫代甲酰胺 | CAS号33842-02-3 二氯亚甲基二甲基氯化铵 | CAS号463-71-8 硫光气 | CAS号124-40-3 二甲胺 | CAS号97-91-6 Methanethioamid... | CAS号97-74-5 一硫化四甲基秋兰姆 | CAS号104994-78-7 O-(6-ox°Cyclohe... | CAS号10345-49-0 Carbamothioic a... | CAS号105638-31-1 3-(3,4-二甲氧基苯基)戊-2-酮 | CAS号93-98-1 N-苯甲酰替苯胺 | CAS号112308-00-6 S-(N-benzoylani... | CAS号112308-02-8 N-benzoyl-S-dim... | CAS号91827-26-8 S-(4-benzamidop... | CAS号3470-50-6 6-羟基-1-萘满酮 | CAS号20876-84-0 2,4-dimethoxy-N... | CAS号20330-88-5 Methanethioamid...

福美双置于氯化亚砜体系中,用 四氯化碳 用作溶剂,化学反应 0.5H,以92%的收率获得二甲氨基硫代甲酰氯
参考文献:氯喹喔啉与邻二硫代苯酚反应的生物正交连接和裂解.
标题:氯喹喔啉与邻二硫代苯酚反应的生物正交连接和裂解.
摘要:提出了一种通过氯喹喔啉(cq)和邻二硫代苯酚(dt)反应的生物正交连接和裂解方法.邻二硫代苯酚对氯喹喔啉的双亲核取代提供了包含四环苯并[5,6] [1,4]二噻吩并[2,3-B]喹喔啉的结合物,该结合物具有强大的内置荧光并释放了其他功能分子.设计了三个可裂解的接头,并成功地用于从蛋白质结合物中释放出含有生物素的分子.Cq-Dt生物正交反应可用于蛋白质的生物正交连接,生物正交切割和反式标记,并显示出易于获得的非天然正交基团的优势,具有吸引人的反应动力学(k2~1.3M-1 S-1),非常好正交基团的生物相容性和结合物的高稳定性.
Doi:10.1002/anie.201913620

专利信息

专利号:WO-0125179-A1
优先权日:1999-10-01
标 题:Preparation of tetracyclic intermediates
发明人：CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
权利人:INST OF DRUG TECHNOLOGY AUSTRA; CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
摘要:The invention provides a process for preparing deoxytetracyclic compounds of formula (I) useful in the synthesis of anthracyclines by the rearrangement of thiono ester derivatives followed by reduction, as well as intermediates useful therefor. In said formula, R is H or optionally protected OH.

专利号:US-7259263-B2
优先权日:2005-06-29
标题:Method of synthesis of azole-containing amino acids
发明人：HLASTA DENNIS J; ZIFICSAK CRAIG A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I): n nThe invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method.

专利号:EP-1904465-B1
优先权日:2005-06-29
标 题 :Method of synthesis of imidazole-amino acid derivatives and related compounds
发明人：HLASTA DENNIS J; ZIFICSAK CRAIG A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I). The invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method.

专利号:US-7678789-B2
优先权日:2005-02-11
标 题 :[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
发明人：FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J M
权利人:SOLVAY PHARM BV
摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): n nwhereinn nwherein the symbols have the meanings given in the specification.

专利号:US-7208613-B2
优先权日:2002-06-20
标 题:Synthesis of s-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate
发明人：JADAV KANAKSINH JESINGBHAI; KAMBHAMPATI SUDHAKAR; CHITTURI TRINADHA RAO; THENNATI RAJAMANNAR
权利人:SUN PHARMACEUTICAL IND LTD
摘要:The present invention provides a convenient process for the preparation of S-fluoromethyl 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate, a compound of formula 1, comprisingn (a) treating 17β-[(N,N-dimethylcarbamoyl)thio]carbonyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene, a compound of formula 3 with alkali metal carbonate-alcohol system to obtain 6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioic acid, a compound of formula 4; (b) reacting the compound of formula 4 with bromofluoromethane to yield the compound of formula 1.

专利号:US-2025179033-A1
优先权日:2021-12-30
标 题 :New antiviral triazole derivatives, their synthesis and their use for treatment of mammalian viral infections
发明人：MAKAROV VADIM; RIABOVA OLGA; LANE THOMAS R; EKINS SEAN
权利人:COLLABORATIONS PHARMACEUTICALS INC; FEDERAL RES CENTER FUNDAMENTALS OF BIOTECHNOLOGY RUSSIAN ACADEMY OF SCIENCE
摘要:A family of triazole derivatives is described. Also described is the use of these triazole derivatives in treating or preventing viral infections, such as human immunodeficiency virus (HIV) infections, and the diseases caused by these infections, such as acquired immunodeficiency syndrome (AIDS). The triazole derivatives, for example, comprise a central triazole group with two substituents comprising an aryl or heteroaryl group. Exemplary derivatives showed excellent HIV inhibitory activity against both wild-type and selected mutant strains of HIV.