CAS: 114772-40-6; 2-Boc-4'-(Bromomethyl)Biphenyl

上下游产品

4’-甲基-[1,1’-联苯]-2-甲酸叔丁酯 Tert-Butyl 4'-Methyl-2-Biphenylcarboxylate 114772-36-0
Tert-Butyl 2-[4-(Hydroxymethyl)Phenyl]Benzoate 145319-09-1
Biphenyl-2-Carboxylic Acid Tert-Butyl Ester
4'-甲基联苯-2-羧酸甲酯 Methyl 4'-Methylbiphenyl-2-Carboxylate 114772-34-8
4'-甲基联苯-2-羧酸 O-Tolylbenzoic Acid 7148-03-0
二氢-3-(异十二碳烯基)呋喃-2,5-二酮 2-Biphenylcarboxylic Acid 947-84-2

邻甲氧基苯甲酸置于盐酸,N-溴代丁二酰亚胺(Nbs),氯化亚砜,草酰氯,过氧化苯甲酰体系中,用 四氢呋喃,四氯化碳,二氯甲烷 用作溶剂,化学反应 42.0H,反应生成4'-溴甲基联苯-2-甲酸叔丁酯
参考文献:非肽血管紧张素ii受体拮抗剂:发现了一系列n-(联苯基甲基)咪唑类有效的口服活性降压药.
标题:非肽血管紧张素ii受体拮抗剂:发现了一系列n-(联苯基甲基)咪唑类有效的口服活性降压药.
摘要:制备了一系列新的非肽血管紧张素ii(aii)受体拮抗剂.这些n-(联苯基-甲基)咪唑,例如2-丁基-1-[[(2'-羧基联苯-4-基)甲基]-4-氯-5-(羟甲基)咪唑,不同于先前报道的n-(苯甲酰氨基苄基)咪唑和相关化合物,因为它们在口服时产生有效的降压作用;较早的系列通常仅在静脉内给药时才有效.已经发现联苯的2'-位的酸性基团是必不可少的.仅邻位取代的酸具有对aii受体的高亲和力和非常好的口服降压效能.羧酸基团已被各种酸性等排体取代,并且发现四唑环是最有效的.四唑衍生物dup 753
Doi:10.1021/jm00112A031

专利信息

专利号:US-10077242-B2
优先权日:2014-12-01
标题 :Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
发明人：GUPTON FRANK; MARTIN ALEX; SIAMAKI ALI; BELECKI KATHERINE
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.

专利号:EP-2149566-A1
优先权日:2008-07-15
标 题 :A process for the preparation of telmisartan
发明人：ROSSI RENZO; BELLINA FABIO; CAUTERUCCIO SILVIA; CASTALDI GRAZIANO
权利人:CHEMO IBERICA SA
摘要:The present invention relates to a process for the preparation of Telmisartan by hydroxycarbonylation of compound of formula (V),n nwherein X is a substituent which can be transformed into a carboxy group by hydroxycarbonylation. The invention also relates to intermediates for the synthesis of Telmisartan.

专利号:EP-2123648-A1
优先权日:2008-05-20
标 题:A process for the preparation of Telmisartan.
发明人：RASPARINI MARCELLO; TUFARO ROBERTO; CASTALDI GRAZIANO
权利人:CHEMO IBERICA SA
摘要:The present invention relates to a process for the preparation of Telmisartan esters and Telmisartan and intermediates for the synthesis thereof.

专利号:US-7692027-B2
优先权日:2005-05-03
标题 :Process for the preparation of telmisartan
发明人：ALLEGRINI PIETRO; RASPARINI MARCELLO; RAZZETTI GABRIELE; BOLOGNA ALBERTO; BARRECA GIUSEPPE
权利人:DIPHARMA SPA
摘要:A process for the preparation of telmisartan (I) and novel intermediates useful for its synthesis.

专利号:US-2017260146-A1
优先权日:2014-12-01
标题 :A convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction