CAS: 113975-22-7; 2-Fluoro-3-Iodopyridine

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685517-67-3 837364-88-2 171197-80-1

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CAS号372-48-5 2-氟吡啶 | CAS号79574-82-6 2-fluoro-3-lith... | CAS号1110734-53-6 3-ethyl-2-fluor... | CAS号171366-19-1 2-氟-4-碘-3-羟甲基吡啶 | CAS号244-76-8 9H-吡啶并[2,3-B]吲哚 | CAS号104830-06-0 2-氨基-3-碘吡啶 | CAS号112197-15-6 3-碘-2-甲氧基吡啶 | CAS号340268-75-9 3-烯丙基-2-氟-4-碘吡啶 | CAS号153034-82-3 2-氟-3-醛基-4-碘吡啶 | CAS号153034-80-1 2-氟-3-甲基-4-碘吡啶 | CAS号214074-22-3 2-环丙基氨基-3-碘吡啶 | CAS号22282-70-8 2-氟-4-碘吡啶

2-氟吡啶置于lithium Diisopropyl Amide,碘体系中,用78%的收率获得2-氟-3-碘吡啶
参考文献:2,3,4-取代吡啶用作三肽模拟物支架的合成方法
标题:2,3,4-取代吡啶用作三肽模拟物支架的合成方法
摘要:描述了在肽模拟物开发中用作支架的2,3,4-取代的吡啶衍生物的合成.已经探索了在卤素舞反应中使用各种亲电试剂来生产3-烷基-2-氟-4-碘吡啶吡啶衍生物作为"功能化支架"的可能性,并探讨了区分两种卤素手柄的反应性的可能性. .发现通过将碘吡啶转化为格利雅衍生物,可以使吡啶的4-位上的氨基酸衍生物有效地偶联,使其与受保护的氨基醛反应.发现吡啶的2-位上的氟取代容易与醇盐亲核试剂反应,而胺的反应性要低得多.
Doi:10.1016/j.Tet.2004.05.048

专利信息

专利号:US-10759743-B2
优先权日:2016-10-24
标 题 :Pd-catalyzed γ-C(sp3)-H arylation / heteroarylation of free amines
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

专利号:US-5496952-A
优先权日:1995-02-07
标题 :Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
发明人：COMINS DANIEL L
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention is directed towards new methods of making DE ring intermediates of Formula (III), ##STR1## wherein Y is H or halogen and R is loweralkyl, which in turn are useful in methods of making camptothecin and camptothecin analogs. The present invention also provides new compounds useful in the methods of making compounds of Formula (III).

专利号:WO-2024044825-A1
优先权日:2022-09-01
标 题:Compound collections, compounds and synthesis thereof
发明人：FLYNN BERNARD; CHEN SHUQI; PRIEBBENOW DANIEL; JASZEWSKI LEO
权利人:UNIV MONASH
摘要:Provided herein are collections of compounds of formula a) to u), and salts thereof, which have polycyclic aromatic scaffolds and thus have structures targeted towards binding polynucleotide therapeutic targets, including polynucleotide-protein complexes. Also provided are compounds and salts themselves, methods of synthesizing such compounds, methods of identifying compounds having activity against a polynucleotide target, use of the compounds as reference compounds in assays, and phenotypic methods of identifying a new polynucleotide target using the compounds.

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.

专利号:US-8828907-B2
优先权日:2009-03-25
标题:Active ingredient combinations having insecticidal and acaricidal properties
发明人：HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG
权利人:HUNGENBERG HEIKE; JESCHKE PETER; VELTEN ROBERT; THIELERT WOLFGANG; BAYER CROPSCIENCE AG
摘要:The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) n nin whichn nR 1 and A have the meanings given in the descriptionn nand, secondly, at least one further known active compound from the class of the chitin synthesis inhibitors, the molting hormone agonists or other classes, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids.

专利号:CN-117024334-A
优先权日:2023-07-20
标 题:A kind of synthesis method of 2-fluoro-3-hydroxypyridine