CAS: 1120-72-5; 2-Methylcyclopentan-1-One

相似化合物

4971-18-0 25144-04-1 25144-05-2

上下游产品

2-chlor°Cyclopentanone methyl magnesium iodide diethyl ether t-chloro-1-methyl-cyclopentan-r-ol(+/-)-2t-chloro-1-methyl-cyclopentan-r-ol 2-methyl-1-phenethyl-cyclopentanol 1-cyclohexyl-2-methyl-cyclopentene -caprolactam 2,2-dimethylcyclopentanone

1-甲基-2-氧代环戊烷-1-羧酸乙酯置于盐酸体系中,化学反应生成2-甲基环戊酮
参考文献:烯醇动力学酮化的立体化学中的阿尔法效应.
标题:烯醇动力学酮化的立体化学中的阿尔法效应.
摘要:烯醇盐和其他强烈离域的阴离子物质的质子化的立体选择性的动力学控制涉及大量的有机反应.从例如烯醇体系的较少受阻侧发生的质子化提供了两种非对映异构体的较不稳定性.但是,前列腺素的合成存在一个明显的差异.本研究处理这种行为的来源.未发现烯醇α碳上取代基的奇怪作用.在某些情况下,迫使α取代基扭曲成构象,从而从其侧面阻断质子供体,从而逆转了质子化的立体化学.在这项研究过程中,研究了许多不同结构的五环烯醇.最后,对酮化反应过程进行了理论研究.
Doi:10.1021/jo034732W

专利信息

专利号:US-6133018-A
优先权日:1997-06-02
标 题 :Enzymatic synthesis of chiral amines using -2-amino propane as amine donor
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE L; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-8471010-B2
优先权日:2008-05-13
标题:Synthesis of dihydrothieno[3,2-d]pyrimidine diols
发明人：FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H
权利人:FRUTOS ROGELIO P; TAMPONE THOMAS G; MULDER JASON ALAN; KRISHNAMURTHY DHILEEPKUMAR; SENANAYAKE CHRIS H; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.

专利号:EP-1075534-B8
优先权日:1998-03-11
标 题 :Improvements in the enzymatic synthesis of chiral amines
发明人：WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
权利人:CELGRO
摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

专利号:US-5446203-A
优先权日:1992-08-25
标题:Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
发明人：MCNELIS EDWARD
权利人:UNIV NEW YORK
摘要:Alternative methods for synthesizing haloenones and haloakenes and their use as starting materials for synthesis of substituted or unsubstituted alkyl and aryl substituted enones and alkenes, including tamoxifen and tamoxifen analogs, using such haloenones and haloalkenes.

专利号:US-10239812-B2
优先权日:2017-04-27
标 题 :Systems and methods for synthesis of phenolics and ketones
发明人：FEDIE RONALD LEIGH; YAN BINGWEN; MCNEFF LARRY C; GREUEL PETER G; MCNEFF CLAYTON V
权利人:SARTEC CORP
摘要:Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing phenolics and ketones is included. The method can specifically include forming a reaction mixture comprising nanocrystalline cellulose (NCC) and water. The method can also include contacting the reaction mixture with a metal oxide catalyst at a temperature of 350 degrees Celsius or higher and a pressure of at least about 3200 psi to form a reaction product mixture. The reaction product mixture can include at least about 20 wt. % phenolics and at least about 10 wt. % ketones as a percentage of the total mass of nanocrystalline cellulose (NCC). Other embodiments are also included herein.

专利号:US-2025010279-A1
优先权日:2021-11-17
标 题:Synthesis of carbonylation catalysts
发明人：WILDERS ALISON M; TEDDER JONATHAN D; BOYCE RONALD; JOSEPH ASHLEY
权利人:NOVOMER INC
摘要:A method including contacting a ligand complex, a metalation compound, and a metal carbonyl in a mixture to form a catalyst. The ligand complex includes one or more of phosphine, imine, and/or hydroxyl groups bound to one or more cyclic structures. The method includes separating the catalyst from the mixture. Contacting the ligand complex with a metalation compound and the metal carbonyl in the mixture to form a catalyst is conducted without isolating any intermediates, performed within a single vessel, and/or performed in a moisture, oxygen, and/or air free environment.