CAS: 107-89-1; 3-Hydroxybutyraldehyde

上下游产品

CAS号75-07-0 乙醛 | CAS号6117-91-5 巴豆醇 | CAS号107-21-1 乙二醇 | CAS号598-32-3 3-丁烯-2-醇 | CAS号111957-98-3 beta-allylethyl... | CAS号2028-63-9 3-丁炔-2-醇 | CAS号4740-77-6 2,6-Dimethyl-1,... | CAS号123-73-9 2-丁烯醛 | CAS号201230-82-2 carbon monoxide | CAS号504-60-9 间戊二烯 | CAS号19781-76-1 6-庚烯-2,4-二醇 | CAS号20030-30-2 2,5,6-trimethyl... | CAS号19780-90-6 2,4-己二醇 | CAS号123-73-9 2-丁烯醛 | CAS号7732-18-5 水 | CAS号66675-42-1 1,1,3-trifluoro... | CAS号75-07-0 乙醛 | CAS号91-63-4 2-甲基喹啉 | CAS号26391-36-6 4-oxobutan-2-yl...

📜1,3-丁二醇置于recombinant Alditol Oxidase From Streptomyces Coelicolor A3(2),Catalase From Bovine Liver体系中,化学反应生成3-羟基丁醛
参考文献:探索天蓝色链霉菌中醛糖醇氧化酶的生物催化范围
标题:探索天蓝色链霉菌中醛糖醇氧化酶的生物催化范围
摘要:探索了在大肠杆菌中重组产生的coelicolor链霉菌a3(2)的黄素醛糖醇氧化酶(aldo)的底物范围.虽然已经确定aldo可以有效地将醛糖醇氧化为d-醛糖,但这项研究表明该酶还具有多种脂族和芳族醇的活性.在c-1和c-2位置含有羟基的醇,例如1,2,4-丁三醇(k M = 170 Mm,K Cat = 4.4 S-1),1,2-戊二醇(k M = 52 Mm,K Cat = 0.85 S-1)和1,2-己二醇(k M=97Mm,K Cat=2.0S-1)容易被aldo接受.此外,该酶对1,2-二醇的氧化具有很高的对映选择性[例如,对于1-苯基-1,2-乙二醇,(R)-对映异构体是首选,E值为74].对于几种二醇,其氧化产物通过gc-Ms和NMR测定.有趣的是,对于所有测试的1,2-二醇,发现其产物是α-羟基酸,而不是预期的α-羟基醛.将(R)-1-苯基-1,2-乙二醇与18
Doi:10.1002/adsc.200900176

专利信息

专利号:US-11866398-B2
优先权日:2018-05-15
标 题:Total synthesis of prostaglandin J natural products by stereoretentive metathesis
发明人：LI JIAMING; CHEN XU; AHMED TONIA S; STOLTZ BRIAN M; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).

专利号:US-10995049-B2
优先权日:2019-07-19
标 题 :Total synthesis of prostaglandin J natural products and their intermediates
发明人：LI JIAMING; XU CHEN; AHMED TONIA S; GRUBBS ROBERT H; STOLTZ BRIAN M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure is directed to methods of preparing prostaglandin J natural products by stereoretentive metatheses reactions and intermediates used in the synthesis of these natural products, including the use of intermediates of Formula (I-A), where R 1 is defined in the specification

专利号:US-6794534-B2
优先权日:2000-06-23
标题:Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; MORGAN JOHN P; SCHOLL MATTHIAS; CHOI TAE-LIM
权利人:CALIFORNIA INST OF TECHN
摘要:The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of α-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are each independently an anionic ligand; n L is a neutral electron donor ligand; and, n R, R 1 R 6 , R 7 , R 8 , and R 9 are each independently hydrogen or a substituent selected from the group consisting of C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl.

专利号:US-6190619-B1
优先权日:1997-06-11
标题:Systems and methods for parallel synthesis of compounds
发明人：KILCOIN CHRISTOPHER; MILLER STEVE; LONG TERRY
权利人:ARGONAUT TECHNOLOGIES INC
摘要:Systems and methods for synthesizing chemical compounds using a plurality reaction vessels. In particular, the present invention provides a synthesis apparatus capable of holding a plurality of reaction vessels for parallel synthesis of multiple discrete compounds or for combinatorial libraries of compounds. In one embodiment, a synthesis apparatus comprises a frame having a plurality of reaction vessel-holding openings and a plurality of valves for use in parallel synthesis of a plurality of compounds within reaction vessels.

专利号:US-10308588-B2
优先权日:2014-12-15
标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
发明人：CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON
权利人:ORGANOFUEL SWEDEN AB
摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.