CAS: 908355-84-0; 7-Chlorothiazolo[4,5-C]Pyridine-2(3H)-Thione

相似化合物

1849-73-6 5331-91-9 214045-74-6

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4-hydroxy-3-nitropyridine

📜4-羟基-3-硝基吡啶置于盐酸,氯,溶剂黄146,Tin(Ll) Chloride,三氯氧磷体系中,用 乙醚,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.83H,反应生成 7-氯噻唑并[4,5-C]吡啶-2-硫醇
参考文献:7'-Substituted Benzothiazolothio-And Pyridinothiazolothio-Purines As Potent Heat Shock Protein 90 Inhibitors
标题:7'-Substituted Benzothiazolothio-And Pyridinothiazolothio-Purines As Potent Heat Shock Protein 90 Inhibitors
摘要:We Report On The Discovery Of Benzo-And Pyridino-Thiazolothiopurines As Potent Heat Shock Protein 90 Inhibitors. The Benzothiazole Moiety Is Exceptionally Sensitive To Substitutions On The Aromatic Ring With A 7'-Substituent Essential For Activity. Some Of These Compounds Exhibit Low Nanomolar Inhibition Activity In A Her-2 Degradation Assay (28-150 Nm),Good Aqueous Solubility,And Oral Bioavailability Profiles In Mice. In Vivo Efficacy Experiments Demonstrate That Compounds Of This Class Inhibit Tumor Growth In An N87 Human Colon Cancer Xenograft Model Via Oral Administration As Shown With Compound 37 (8-(7-Chlorobenzothiazol-2-Ylsulfanyl)-9-(2-Cyclopropylamino-Ethyl)-9H-Purin-6-Ylamine).
DOI:10.1021/jm051146H