2-Chlor-2-Methyl-Butin-(3)-Saeure-Aethylester置于palladium On Activated Charcoal 氢气体系中,用 乙醇 作为反应溶剂,化学反应生成 2-甲基丁酸乙酯 参考文献:Dugat,D. Et Al.,Comptes Rendus Des Seances De L'Academie Des Sciences,Serie C: Sciences Chimiques,1977,Vol. 284,P. 803-805 标题:Dugat,D. Et Al.,Comptes Rendus Des Seances De L'Academie Des Sciences,Serie C: Sciences Chimiques,1977,Vol. 284,P. 803-805
专利号:WO-2017033128-A1 优先权日:2015-08-25 标题 :Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors 发明人:HOOK DAVID; KU JIE; ZHOU JIANGUANG 权利人:NOVARTIS AG; HOOK DAVID; KU JIE; ZHOU JIANGUANG 摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.
专利号:US-7329767-B2 优先权日:2003-10-03 标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
专利号:US-8007841-B2 优先权日:2003-10-03 标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof 发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C 权利人:INT FLAVORS & FRAGRANCES INC 摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.
专利号:US-7501536-B2 优先权日:2005-01-19 标题 :Odorant compounds, synthesis method, and uses of said compounds 发明人:JAUNKY PIOTR; MANE JEAN; SCHROEDER MARTIN 权利人:MANE FILS V 摘要:A compound of general formula (I) with or without the double bond illustrated by the dotted line. In formula (I), X is a CHO, CH2OH, CH2OC(O)R or CH(OR)2 group, and R represents a linear or branched C1-C5 alkyl or alkenyl chain. The synthesis method for the compound, and especially the 6,8-dimethyl-non-7-enal (1) prepared by the hydroformylation of the 5,7-dimethyl-octa-1,6-diene is also disclosed, as well as compositions containing the compounds of formula (I). Due to the odorant properties thereof, the compounds are highly useful in perfumery, especially for cosmetic products and household products.
专利号:WO-2018192923-A1 优先权日:2017-04-18 标题 :Alpha alkylation of aldehyde with a polycyclic olefin 发明人:QUINTAINE JULIE; MACMILLAN DAVID W C 权利人:FIRMENICH & CIE 摘要:The present invention relates to the field of organic synthesis and more specifically to the alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof and wherein R represents a hydrogen atom or C 1-8 linear alkyl group; R 1 , R 2 , R 3 and R 4 represent, when taken separately, independently of each other, a hydrogen atom or a C 1-2 linear alkyl group or a C 3-4 linear or branched alkyl group; or R 2 and R 3 , when taken together, represent a C 4-10 linear, branched or cyclic alkanediyl group and n is 1 or 2.
专利号:EP-1362864-A1 优先权日:2003-06-30 标题 :Method for synthesis of perindopril and its pharmaceutically acceptable salts
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