CAS: 709-09-1; 3,4-Dimethoxynitrobenzene

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CAS号91-16-7 1,2-二甲氧基苯 | CAS号4998-07-6 4,5-二甲氧基-2-硝基苯甲酸 | CAS号122775-35-3 3,4-二甲氧基苯硼酸 | CAS号3316-09-4 4-硝基儿茶酚 | CAS号616-38-6 碳酸二甲酯 | CAS号53606-41-0 (2-methoxy-5-ni... | CAS号97-52-9 2-甲氧基-4-硝基苯胺 | CAS号455-93-6 2-氟-4-硝基苯甲醚 | CAS号77-78-1 硫酸二甲酯 | CAS号67-56-1 甲醇 | CAS号3251-56-7 2-甲氧基-4-硝基苯酚 | CAS号636-93-1 5-硝基愈创木酚 | CAS号10496-75-0 2-甲氧基-5-硝基苯甲腈 | CAS号119-53-9 2-羟基-2-苯基苯乙酮 | CAS号100-52-7 苯甲醛 | CAS号100-51-6 苯甲醇 | CAS号26884-57-1 1,2,3,4-四溴-5,6-二甲氧基苯 | CAS号7461-55-4 1-bromo-2,3-dim... | CAS号97459-72-8 4-(2-甲氧基-4-硝基苯基)吗啉 | CAS号7595-31-5 2-硝基-4,5-二甲氧基苯胺

邻苯二甲醚置于iron(Iii) Chloride Hexahydrate,Potassium Nitrate体系中,化学反应 6.0H,以92%的收率获得产物1,2-二甲氧基-4-硝基苯
参考文献:使用绿色离子液体形成芳香碳-杂原子键的生态友好方法
标题:使用绿色离子液体形成芳香碳-杂原子键的生态友好方法
摘要:据报道,通过使用新型绿色离子液体,在无溶剂和温和条件下(无助氧化剂,无强酸和无毒试剂)形成芳香族碳-杂原子键的新的可持续方法.选择甲氧基芳烃的溴化作为模型反应.该反应方法仅基于天然溴化钠,该溴化钠在离子液体中转化为亲电溴化试剂,可以轻松地从熔融的盐fecl 3制备六水合物.在简单且环境友好的条件下,使用这种原位反应生成的试剂进行溴化反应可提供非常好的收率和出色的区域选择性.为了了解不加任何强氧化剂的溴化钠的溴极性反转的异常现象,通过拉曼光谱和直接注入电喷雾电离质谱(esi-Ms)对反应介质的分子结构进行了表征.进行使用密度泛函理论方法的广泛调查计算来形容表明溴的间接氧化机制-通过新的铁加合物.该方法的多功能性先后应用于在熔融六水合fecl 3中使用kno 3和kscn进行甲氧基芳烃的硝化和硫氰化反应.
DOI:10.1002/chem.202003827

专利信息

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:US-6022963-A
优先权日:1995-12-15
标 题:Synthesis of oligonucleotide arrays using photocleavable protecting groups
发明人：MCGALL GLENN H; NAM NGO QUOC
权利人:AFFYMETRIX INC
摘要:Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Ar-C(R1)(R2)-O-C(O)- wherein: Ar is an optionally substituted fused polycyclic aryl or heteroaromatic group or a vinylogous derivative thereof; R1 and R2 are independently H, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or optionally substituted heteroaromatic, or a vinylogous derivative of the foregoing; and X is a leaving group, a chemical fragment linked to Ar-C(R1)(R2)-O-C(O)- via a heteroatom, or a solid support; provided that when Ar is 1-pyrenyl and R1=R2=H, X is not linked to Ar-C(R1)(R2)-O-C(O)- via a nitrogen atom. Preferred embodiments are those in which Ar is a fused polycyclic aromatic hydrocarbon and in which the substituents on Ar, R1 and R2 are electron donating groups. A particularly preferred protecting group is the 'PYMOC' protecting group, pyrenylmethyloxycarbonyl, where Ar=pyrenyl and R1=R2=H. Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-2002055185-A1
优先权日:1997-08-07
标 题 :Complex chemical compound, synthesis and various applications of said compound
发明人：MINARD CLAIRE; CHAIX CAROLE; DELAIR THIERRY; MANDRAND BERNARD
摘要:The invention concerns a complex chemical compound comprising a solid carrier and at least a conjugate consisting of an organic polymer and a plurality of priming biomers. The invention also concerns the synthesis of said chemical compound for biopolymer synthesis and the use of said complex chemical compound after synthesis as ligand for amplifying or detecting and/or capturing target molecules.

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

专利号:US-9593071-B2
优先权日:2011-11-22
标题 :Process for the preparation of gamma amino acids and intermediates used in said process
发明人：ADAMO MAURO
权利人:ROYAL COLLEGE SURGEONS IRELAND
摘要:The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.