CAS: 62584-30-9; 4-Chloro-3,5-Bis(Trifluoromethyl)Benzonitrile

该化合物是一种化学化合物,其特点是芳香结构,包括一个以两个三氟甲基组和氯苯三硝基苯基酸酯替换的苯环,其独特的电子特性使它成为研究和开发的宝贵化合物,特别是在合成氟化化合物方面.在处理时,应参考安全数据,因为卤化化合物可能对环境和健康造成危害.

英文名称4-Chloro-3,5-Bis(Trifluoromethyl)Benzonitrile
中文名称4-氯-3,5-双(三氟甲基)苯甲腈
IUPAC名称4-chloro-3,5-bis(trifluoromethyl)benzonitrile
其它别名4-Chloro-3,5-Bis-Trifluoromethyl-Benzonitrile; 3,5-Bis(Trifluoromethyl)-4-Chlorobenzonitrile; 3,5-Bis(Trifluoromethyl)-4-Chlorobenzonitrile, Tech; 3,5-Bis(Trifluoromethyl)-4-Chlorobenzonitrile 93%; 3,5-Bis(Trifluoromethyl)-4-Chlorobenzonitrile; 4-Chloro-3,5-Bis(Trifluoromethyl)Benzonitrile, Technical Grade
CAS编号62584-30-9
MFCD编号:MFCD03412181
EINECS号:690-457-8
分子式:C9H2ClF6N
分子量:273.56
产品CID: 1607294
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: TUWQECDDVRORJX-UHFFFAOYSA-N
InChI=1S/C9H2ClF6N/c10-7-5(8(11,12)13)1-4(3-17)2-6(7)9(14,15)16/h1-2H…
计算化学: 氢键受体数1.0氢键供体数0可旋转键数0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
危险等级6.1
UN编号3276.0
危险品标志Xi
风险等级Irritant
包装等级Ⅲ
安全声明26-36/37/39
危险类别码20/21/22-36/37/38

欧盟法规

ECHA物质C&L通报

合成工艺路线路线简述

海关参考信息

2902300000-甲苯
2903919090-氯苯
2903991000-对氯甲苯
2903399090-其他无环烃卤化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9714226-B2
优先权日:2011-07-29
标题:Hydrazide containing nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; MCCAULEY DILARA; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: n nor a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

专利号:US-9428490-B2
优先权日:2011-07-29
标题 :Nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD
权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD; KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.