专利号:US-7038043-B1 优先权日:1995-08-11 标 题:Glycosylated indolocarbazole synthesis 发明人:WOOD JOHN L; STOLTZ BRIAN M; DIETRICH HANS-JURGEN; PFLUM DEREK A 权利人:UNIV YALE 摘要:Indolocarbazoles are furanosylated (e.g., 7 ) with acetals (e.g., 8 ) or their open chain congeners (e.g., 9 ) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10 ) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g., 11 ) under conditions know to effect oxidation and benzylic acid type rearrangements, and pyranosylated indolocarbazoles (e.g., 11 ) are prepared via ring expansion of the furanosylated congeners (e.g., 10 )
专利号:WO-2019067396-A1 优先权日:2017-09-26 标 题 :ZAP-70 KINASE INHIBITOR COMPOSITIONS, METHODS AND USES THEREOF 发明人:BURK MARK J; CHEN BRANDON; LI JINGYI; BACHAN SHAWN 权利人:SNAP BIO INC 摘要:Disclosed are compounds of formulas (I) and (V) and compositions thereof useful as inhibitors of ZAP-70 kinase. Also provided are methods of synthesis and methods of use of ZAP-70 inhibitors in treating individuals suffering from organ transplant rejection, autoimmune diseases and cancer.
专利号:US-11319320-B2 优先权日:2017-11-06 标题:PIM kinase inhibitor compositions, methods, and uses thereof 发明人:BURK MARK J; CHEN BRANDON; LI JINGYI; BACHAN SHAWN 权利人:SNAP BIO INC 摘要:This application relates to compounds of formulae (I) and (II) and compositions thereof useful as inhibitors of PIM kinases. Also provided are methods of synthesis and methods of use of PIM inhibitors in treating individuals suffering from cancerous malignancies.
参考文献:10.1055/s-0033-1338969 摘要:Sperry J, Blair L. Palladium-Catalyzed Heteroannulation Approach to 1,2-Bis(3-indolyl)ethanes. Synlett. 2013 Aug 12;24(15):1931–6. doi: 10.1055/s-0033-1338969. 参考文献:10.1055/s-0040-1719896 摘要:Knipe PC, Sweet JS. Catalytic Enantioselective Synthesis of C–N Atropisomeric Heterobiaryls. Synthesis. 2022 Feb 23;54(09):2119–32. doi: 10.1055/s-0040-1719896. 参考文献:10.1007/s40843-025-3770-9 摘要:Guo S, Lv X, Li X, Zhou K, Chen Q, Li Q, Su P, Meng L, Lu C. Strategic dihedral angle engineering for high-efficiency through-space charge transfer TADF emitters. Sci. China Mater. 2026 Jan 05;69(2):1088–97. doi: 10.1007/s40843-025-3770-9.