CAS: 603-45-2; Rosolic Acid, Indicator

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CAS号144-62-7 草酸 | CAS号108-95-2 苯酚 | CAS号456-55-3 三氟甲氧基苯 | CAS号56-23-5 四氯化碳 | CAS号64-18-6 甲酸 | CAS号76-06-2 氯化苦 | CAS号32858-93-8 2-(三氟甲氧基)苯酚 | CAS号95-57-8 邻氯苯酚 | CAS号450-96-4 1-氯-2-(三氟甲氧基)苯 | CAS号106-44-5 对甲酚 | CAS号53153-46-1 3,3,5-trimethyl... | CAS号603-44-1 4,4’,4’’-亚甲基三苯酚 | CAS号611-99-4 4,4'-二羟基二苯甲酮 | CAS号108-95-2 苯酚 | CAS号106-51-4 苯醌 | CAS号609-23-4 2,4,6三碘苯酚 | CAS号548-61-8 4,4',4''-三氨基三苯甲烷 | CAS号467-62-9 付玫瑰苯胺

📜三氟甲氧基苯置于氢氟酸,五氯化钽体系中,化学反应 4.0H,以25%的收率获得产物玫红酸
参考文献:Lability Of The Trifluoromethyl Group Of Trifluoromethoxybenzenes Under Hf/lewis Acid Conditions
标题:Lability Of The Trifluoromethyl Group Of Trifluoromethoxybenzenes Under Hf/lewis Acid Conditions
摘要:The Trifluoromethyl Functionality Of Trifluoromethoxybenzenes (Trifluoromethyl Phenyl Ethers) Becomes Labile Under Hf/lewis Acid Conditions. Substrates With An Unsubstituted Para-Position Shed Their-Cf(3) Groups While Performing A Friedel-Crafts Reaction Upon Another Substrate Molecule'S Trifluoromethoxy Group To Generate P-Rosolic Acids. Substrates That Had Blocking Groups At The Para-Positions Reacted Ortho. The Electron Donating Substituents Methoxy And Phenoxy Interfered With The Formation Of Rosolic Acids. (C) 2010 Elsevier B.V. All Rights Reserved.
DOI:10.1016/j.Jfluchem.2010.08.003

专利信息

专利号:US-7355036-B2
优先权日:2001-07-03
标 题 :Two-stage protective groups for the synthesis of biopolymers
发明人：GUEIMIL RAMON; SCHEFFLER MATTHIAS; STAEHLER PEER F; BEIJER BARBRO
权利人:FEBIT AG
摘要:The invention relates to a method for the synthesis of a nucleic acid by gradual breakdown from protected synthesis building blocks carrying two-stage protective groups. The two-stage protective groups are split by means of a first exposure step and a subsequent chemical treatment step

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.

专利号:US-2004054162-A1
优先权日:2001-10-30
标 题:Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
摘要:The present invention provides methods for detecting the presence of a target molecule by the use of nucleotide analogs containing moieties that enable detection. Such analogs may be incorporated into nucleic acids. In one embodiment, nucleotide analogs are used in a process generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators or chain terminators to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-7135565-B2
优先权日:2000-07-28
标题 :Synthesis of polynucleotides using combined oxidation/deprotection chemistry
发明人：DELLINGER DOUGLAS J; PERBOST MICHAEL G M; CARUTHERS MARVIN H; BETLEY JASON R
权利人:UNIV COLORADO
摘要:A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the second nucleoside having a hydroxyl protecting group that is a non-carbonate protecting group. The product of the foregoing step is exposed to a composition which both oxidizes the formed phosphite to a phosphate and deprotects the protected hydroxyl of the coupled nucleoside. The method has particular application to fabricating an addressable array of polynucleotides on a substrate which carries substrate bound moieties each with a hydroxyl group.