CAS: 5673-07-4; 2,6-Dimethoxytoluene

该化合物是一种芳香有机化合物,其特点是有两种甲苯基组(-OCH3),附于甲苯脊,其分子结构中含有一种苯环,一个甲基组和两个甲氧替代体,位于2和6个位置,影响其化学反应和物理特性.该化合物一般没有颜色,可粉色黄色液,具有甜味,芳香味.它相对非极性,在水溶性有限的情况下使其溶于有机溶剂中. 2,6-二甲基氧甲苯经常被用作有机合成的中间体,特别是在生产药品,农用化学品和其他精密化学品时.其甲氧基苯基化合物组可以参与各种化学反应,包括电益替代和核感激素攻击,提高其在合成化学中的效用.在处理和储存时,应参考安全数据,因为任何化学物质都可确保采取适当的预防措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3-methoxy-2-methylphenol 2-methylbenzene-1,3-diol dimethyl sulfate 1,3-Dimethoxybenzene 1-(2-hydroxy-4-methoxy-3-methyl-phenyl)-heptadecan-1-one 2-6-dimethoxybenzoic acid 1-bromo-2,4-dimethoxy-3-methylbenzene 2,4-dimethoxy-3-methylbenzaldehyde

合成工艺路线路线简述

    甲基2,4-二羟基-3-苯甲酸乙酯置于氢氧化钾,Sodium Hydroxide体系中,化学反应生成 2,6-二甲氧基甲苯
    参考文献:Shibata,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1939,Vol. 59,P. 323,325; Dtsch. Ref. S. 111
    标题:Shibata,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1939,Vol. 59,P. 323,325; Dtsch. Ref. S. 111

    海关参考信息

    专利信息


    专利号:US-2012215002-A1
    优先权日:2009-10-09
    标 题:Synthesis of optically active intermediate for the preparation of montelukast
    发明人:LEFORT LAURENT
    权利人:LEFORT LAURENT
    摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).

    专利号:WO-0140193-A1
    优先权日:1999-12-03
    标题:Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-2002103381-A1
    优先权日:2000-11-30
    标 题 :Method for the synthesis of pyrazolines
    发明人:BOLDI ARMEN M
    摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

    专利号:US-11999757-B2
    优先权日:2017-11-01
    标 题:Synthesis of boronate ester derivatives and uses thereof
    发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
    权利人:MELINTA SUBSIDIARY CORP
    摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

    专利号:US-10669292-B2
    优先权日:2014-05-05
    标 题 :Synthesis of boronate salts and uses thereof
    发明人:HECKER SCOTT; BOYER SERGE
    权利人:REMPEX PHARMACEUTICALS INC
    摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

    专利号:US-5300638-A
    优先权日:1991-07-31
    标题:Asymmetric synthesis of taxol side chain
    发明人:FARINA VITTORIO; HAUCK SHEILA I
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:The present invention relates to a process for the preparation of (3R, 4S)-3-hydroxy-4-phenyl-2-azetidinone derivatives which are useful intermediates in the synthesis of taxol from baccatin III, said process comprises reacting an acyloxyacetyl halide with an imine derived from L-threonine; and to compounds of formula (III) which are produced in said process: ##STR1## wherein Ar is phenyl; R 1 is hydrogen, an acyl radical of a carboxylic acid, or a carbonic acid ester radical; R 2 is hydrogen or a carboxy protecting group; and R 3 is hydrogen or a hydroxy protecting group.
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    合成参考文献


    摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2013) 2, 265.
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