专利号:WO-2025215126-A1 优先权日:2024-04-12 标题:Synthesis of vidofludimus and its calcium salt 发明人:VITT DANIEL; IGLICAR PETRA; GEGE CHRISTIAN; Mühler Andreas; KOHLHOF HELLA; GRÖPPEL MANFRED 权利人:IMMUNIC AG 摘要:The invention relates to the process of preparation of 2-fluoro-4-(3-methoxyphenyl)aniline (3) as an intermediate. Said intermediate 2-fluoro-4-(3-methoxyphenyl)aniline (3) is obtained in a Suzuki coupling reaction from (3-methoxyphenyl)boronic acid (1) and 4-bromo-2-fluoro-aniline (2). The invention further relates to the synthesis of vidofludimus (5) from said intermediate 2-fluoro-4-(3-methoxy-phenyl)aniline (3) and from 1-cyclopentene-1,2-dicarboxylic anhydride (4). The invention further relates to the synthesis of vidofludimus calcium (6) from said vidofludimus (5) and from a calcium salt, preferably Ca(OH)2.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2024409557-A1 优先权日:2023-05-09 标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators 发明人:GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P 权利人:AMGEN INC 摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).
专利号:CN-102731370-A 优先权日:2012-07-13 标 题 :Preparation method of ionic liquid and method for catalyzing synthesis of biphenyl compounds using ionic liquid palladium carbon
专利号:US-9752084-B2 优先权日:2013-02-26 标题 :Block copolymers, synthesis and application as dehydrating and desalting of heavy crudes 发明人:FLORES OROPEZA EUGENIO ALEJANDRO; FLORES SANDOVAL CESAR ANDRES; REYES MARTINEZ REYNA; HERNANDEZ CORTEZ JOSE GONZALO; LOPEZ ORTEGA ALFONSO; CASTRO SOTELO LAURA VERONICA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR 权利人:MEXICANO INST PETROL 摘要:The present invention is related to formulations consisting by block copolymers α,ω-di-aryl or alkyl sulfonates of poly(ethylene oxide) w -poly(propylene oxide)-poly(ethylene oxide) w of bis-ammonium and block copolymers α,ω-di-amine of poly(ethylene oxide) w -poly(propylene oxide)-poly(ethylene oxide) w , that are effective in the dewatering and desalting crude whose specific gravities are within the range of 14 to 23° API.
专利号:EP-4590663-A2 优先权日:2022-09-21 标题 :Synthesis of cyclopropane carboxylic acids