CAS: 461-97-2; 3,5-Dimethylfluorobenzene

上下游产品

CAS号108-69-0 3,5-二甲基苯胺 | CAS号172975-69-8 3,5-二甲基苯硼酸 | CAS号22445-41-6 3,5-二甲基-1-碘苯 | CAS号325142-93-6 2-(3,5-二甲基苯基)-4... | CAS号108-38-3 间二甲苯 | CAS号452-64-2 4-氟邻二甲苯 | CAS号315-12-8 5-氟-1,3-二甲基-2-硝基苯 | CAS号315-13-9 1-氟-3,5-二甲基-2-硝基苯 | CAS号392-70-1 4-氟-2,6-二甲基苯胺 | CAS号200799-19-5 2-(溴甲基)-5-氟-1,3-二甲苯 | CAS号255375-90-7 5-氟间苯二甲醛 | CAS号14659-61-1 4-氟-2,6-二甲基苯甲腈 | CAS号14994-16-2 2-氯-5-氟-1,3-二甲苯 | CAS号214774-61-5 2,4-二氯-5-氟-1,3-二甲苯 | CAS号1583-66-0 5-氟间苯二甲酸 | CAS号88972-03-6 4-fluoro-2,6-di...

5-硝基间二甲苯置于tetrafluoroboric Acid,Palladium On Activated Charcoal,Sodium Nitrite体系中,用 乙醇 作为反应溶剂,-5.0~100.0 °C,300.01 Kpa 条件下,反应 2.41H,反应生成 3,5-二甲基氟苯
参考文献:一种1,5-二(氯甲基)-3-氟苯的合成方法
标题:一种1,5-二(氯甲基)-3-氟苯的合成方法
摘要:本发明公开了一种1,5-二(氯甲基)-3-氟苯的合成方法,属于化学合成领域.本发明将3,5-二甲基氯苯中加入浓硫酸和发烟硝酸在冰浴中得3,5-二甲基硝基苯,再向其中加入乙醇和钯炭,向其中通入氢气,得到3,5-二甲基苯胺,再和四氟硼酸,冰浴在滴加亚硝酸钠溶液,滴加后过滤,得滤渣干燥,再加入分解,在加入水和石油醚蒸馏得到l,3-二(氯甲基)-5-氟苯.

专利信息

专利号:US-7615300-B2
优先权日:2005-08-30
标 题 :Development of novel proton-conductive polymers for proton exchange membrane fuel cell (PEMFC) technology
发明人：BAE CHULSUNG
权利人:REGENTS UNIVERSITY AND COMMUNI
摘要:New thermally and chemically stable sulfonic acid-containing polymers are synthesized via post-sulfonation of aromatic polymers. These new polymers provide unique benefits to proton exchange membrane fuel cell technology (“PEMFCâ€?). As a sulfonic acid moiety can be easily installed into an aromatic ring via electrophilic sulfonation, even in the presence of an electron-withdrawing substituent such as —F, rigid polymers consisting of aromatic rings at either the side chain or main chain can be prepared with a wide range of substituents and flexibility in properties. Novel synthetic procedures are provided for synthesis of the polymers.

专利号:US-12071388-B2
优先权日:2020-12-24
标 题:Full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds
发明人：YUAN QILIANG; MIAO YONGYI; SHI YONGGEN; ZHANG YIQIANG; CHEN YINHAO; WANG CHAO
权利人:FUJIAN ZHONGXIN FLUORIDE MATERIAL GAOBAO TECH CO LTD; ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD
摘要:A full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds. Aromatic amine and hydrogen fluoride are respectively pumped into thermostats A and B, then flow into micro-channel reactor C for salt forming reaction whose temperature is kept constant; sulfuric acid solution of nitrosylsulfuric acid is pumped into thermostat D; after keeping the temperature constant, the sulfuric acid solution of nitrosylsulfuric acid and salt forming product flowing out from the micro-channel reactor C flow into micro-channel reactor E for diazotization reaction; the obtained product flows into micro-channel reactor F for thermal decomposition reaction, is cooled in cooler G, then enters three-phase separator H for continuous separation, fluorine-containing aromatic hydrocarbon crude product is subjected to continuous alkaline washing, drying and rectification to obtain fluorine-containing aromatic hydrocarbon finished product, and mixture of hydrofluoric acid and sulfuric acid is continuously distilled to obtain hydrogen fluoride and sulfuric acid.

专利号:US-9580409-B2
优先权日:2011-11-07
标 题:Modulators of opioid receptors and methods of use thereof
发明人：MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:US-9555039-B2
优先权日:2011-05-09
标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

专利号:US-9169209-B2
优先权日:2011-05-04
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.