专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:WO-2023276983-A1 优先权日:2021-06-28 标题 :Synthesis intermediate for beraprost or optically active form thereof, and method for producing same 发明人:AOYAGI SHIGENOBU; YAMADA RYO 权利人:OUCHI SHINKO CHEMICAL IND CO LTD 摘要:The present disclosure provides: a novel synthesis intermediate for beraprost or an optically active form thereof; and a production method using the synthesis intermediate. More specifically, in the present disclosure, a compound represented by general formula (I) or (II) or an optically active form thereof is used as a synthesis intermediate in the production of beraprost or an optically active form thereof.
专利号:WO-2013065066-A1 优先权日:2011-11-02 标 题 :Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine 发明人:PANDEY BIPIN; DAVE MAYANK GHANSHYAMBHAI; KOTHARI HIMANSHU M; SHUKLA BHAVIN SHRIPRASAD; MENDIRATTA SANJEEV KUMAR; JOSHI RUPAL; TRIVEDI UMANG 权利人:CADILA HEALTHCARE LTD; PANDEY BIPIN; DAVE MAYANK GHANSHYAMBHAI; KOTHARI HIMANSHU M; SHUKLA BHAVIN SHRIPRASAD; MENDIRATTA SANJEEV KUMAR; JOSHI RUPAL; TRIVEDI UMANG 摘要:The present invention relates to synthesis of 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2- amine of Formula (I) either in its racemic (R/S) form or any of its optically active (S) or (R) forms or enantiomeric excess mixture of any of the forms by novel processes. The invention further relates to certain novel intermediates useful in the preparation of compound of Formula (I) and processes for their preparation.
专利号:CN-118164894-A 优先权日:2024-03-13 标 题 :Synthesis method of 3-aminoindole compound
专利号:CN-119331043-A 优先权日:2024-10-17 标题 :Synthesis method of steroid chiral amine
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