CAS: 37794-19-7; 6-Fluoro-2-Methyl-2,3-Dihydro-1H-Inden-1-One

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3-(4-fluorophenyl)-2-methylpropanoic acid (3-fluorophenyl)isopropenylketone sodium carbonate 2-bromo-5-fluorobenzaldehyde 5-fluoro-2-methyl-1H-indene-3-acetic acid

3-(4-Fluorophenyl)-2-Methylacrylic Acid置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 作为反应溶剂,80.0 °C,1.01 Mpa 条件下,反应 36.0H,反应生成 6-氟-2-甲基-1-茚酮
参考文献:Synthesis And Sar Study Of Modulators Inhibiting Trxrα-Dependent Akt Activation
标题:Synthesis And Sar Study Of Modulators Inhibiting Trxrα-Dependent Akt Activation
摘要:Rxr Alpha Represents An Intriguing And Unique Target For Pharmacologic Interventions. We Recently Showed That Sulindac And A Designed Analog Could Bind To Rxr Alpha And Modulate Its Biological Activity,Including Inhibition Of The Interaction Of An N-Terminally Truncated Rxr Alpha (Trxr Alpha) With The P85 Alpha Regulatory Subunit Of Phosphatidylinositol-3-Oh Kinase (Pi3K). Here We Report The Synthesis,Testing And Sar Of A Series Of Novel Analogs Of Sulindac As Potential Modulators For Inhibiting Trxr Alpha-Dependent Akt Activation. A New Compound 30 Was Identified To Have Improved Biological Activity. (C) 2013 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2013.01.012