CAS: 329-56-6; L-Noradrenaline Hydrochloride

📜以 氘代甲醇,重水 用作溶剂,化学反应生成(R)-(-)-去甲肾上腺素盐酸盐,
参考文献:迈向合成肾上腺素受体-形状选择性肾上腺素在水中的识别.
标题:迈向合成肾上腺素受体-形状选择性肾上腺素在水中的识别.
摘要:一种经过合理设计的新受体分子结合了水中的肾上腺素衍生物.它的结合模式模仿了天然受体中非共价相互作用的相互作用.对于纤细的多巴胺骨架,可以实现较高的形状选择性,并导致具有α取代基的底物(如氨基酸衍生物)被排斥.
Doi:10.1002/1521-3773(20010903)40:17<3148::Aid-Anie3148>3.0.Co;2-S

专利信息

专利号:US-4035405-A
优先权日:1976-07-09
标题 :Novel synthesis for preparing the hydrochloride salt of selected catecholamine derivatives
发明人：BODOR NICOLAE S; YUAN SUN-SHINE
权利人:INTERX RESEARCH CORP
摘要:Compounds of the formula: ##STR1## wherein R represents a straight or branched C 1 -C 5 alkyl group; and R 1 in each occurrence represents an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, ##STR2## having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, ##STR3## wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, or alkanoylamino having 1-6 carbon atoms groups; are prepared in substantial purity and yield, using as the chloride ion donor, cesium chloride (CsCl). n The compounds prepared by the process claimed herein exhibit sympathomimetic activity and are thus useful in eliciting sympathomimetic responses in warm-blooded animals, e.g., reduction in intraocular pressure, miosis, mydriasis, bronchodilation, etc.

专利号:CN-115073312-A
优先权日:2022-07-15
标题 :A new method for the synthesis of norepinephrine bitartrate

专利号:CN-112079733-A
优先权日:2020-09-25
标 题:A kind of method for asymmetric synthesis of norepinephrine bitartrate

专利号:CN-112079733-B
优先权日:2020-09-25
标题 :A kind of method for asymmetric synthesis of norepinephrine bitartrate

专利号:CN-111019981-A
优先权日:2019-12-27
标题:Asymmetric synthesis of R-norepinephrine

专利号:JP-S60214765-A
优先权日:1976-07-09
标题 :Synthesis method of catecholamine derivative hydrochloride