CAS: 29415-97-2; Methyl 3-Bromo-4-Hydroxybenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号14348-41-5 3-溴-4-羟基苯甲酸 | CAS号99-76-3 尼泊金甲酯 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号99-96-7 4-羟基苯甲酸 | CAS号67201-23-4 methyl 2-trimet... | CAS号35450-37-4 3-溴-4-甲氧基苯甲酸甲酯 | CAS号149817-68-5 4-乙酰氧基-3-溴-苯甲酸甲酯 | CAS号35354-74-6 和厚朴酚 | CAS号160753-84-4 3-乙酰基-5-溴-4-羟基苯甲酸甲酯 | CAS号117738-82-6 3-氰基-4-甲氧基苯甲酸 | CAS号35406-31-6 2-(4-hydroxy-3-... | CAS号14348-41-5 3-溴-4-羟基苯甲酸 | CAS号1345014-21-2 4-Hydroxy-3-(4,... | CAS号213598-11-9 3-氰基-4-异丙氧基苯甲酸甲酯 | CAS号213598-10-8 3-溴-4-异丙氧基苯甲酸甲酯

对羟基苯甲酸甲酯置于溴体系中,用 溶剂黄146 用作溶剂,以99%的收率获得3-溴-4-羟基苯甲酸甲酯
参考文献:铁电液晶.第9部分.结合有反式-1,4-二取代的环己烷环的侧向取代的苯甲酸苯酯†
标题:铁电液晶.第9部分.结合有反式-1,4-二取代的环己烷环的侧向取代的苯甲酸苯酯†
摘要:约65结合了多样化的苯基苯甲酸酯反式-1,4-二取代的环己烷环和已经合成了至少一个侧向取代基.已经系统地研究了这些材料的液晶转变温度对酯的不同位置上的各种侧向取代基(f,Cl,Cn和br)的依赖性.已经对标准酯的不同位置上多达四个f原子的影响进行了深入研究,并为宽近晶c介晶范围确定了最佳组合.结果,制备了包含4-烷氧基-2,3-二氟苯甲酸部分的三个同源系列.将另外的cc键引入连接至这些酯中的一些酯的环己烷环的烷基链中,并确定所得的转变温度的改变.三酯系列结合有横向的取代基和光学活性的(+)-(S)-(1-甲基庚基)氧基取代基也已经合成,并且观测到类似的效果.这些材料可用作电光显示设备应用的手性近晶c混合物的重要成分.
Doi:10.1002/hlca.19890720319

专利信息

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-6075166-A
优先权日:1995-03-31
标题 :Photolytically cleavable encoding and linking agents for use in combinatorial chemistry
发明人：GARIGIPATI RAVI SHUNKER; ADAMS JERRY LEROY
权利人:SMITHKLINE BEECHAM CORP
摘要:The present invention is to novel photochemically cleavable aryl sulfonamides of the formula n n P--A.sub.3 --A.sub.2 --A.sub.1 --S(O).sub.2 NR.sub.1 R.sub.2 n n wherein n R 1 and R 2 are independently selected from optionally substituted alkyl, arylalkyl or heteroarylalkyl; n A 1 is an aryl or heteroaryl moiety; n A 2 is a linking agent is an aryl, heteroaryl, arylalkyl, heteroaryl alkyl, or an alkyl, wherein the alkyl moiety in the arylalkyl, heteroaryl alkyl, or alkyl group is optionally interrupted one or more times independently by oxygen, NR 3 , sulfur or an amide group; n R 3 is alkyl; n A 3 is an electron rich aryl or heteroaryl moiety having an E 1/2 potential of 0.5 to 2.0 and which moiety is capable of forming an exciplex; n P is a solid support. n Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, for use in non-sequential encoding, as a tagging agent. n Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, as a linking agent which is bound to a solid support, and upon photolytic cleavage will provide a free amine of the desired final products, i.e. the use of sulfonamides for the solid phase synthesis of amines.

专利号:BR-122018077504-B1
优先权日:2009-11-13
标题 :METHODS FOR SYNTHESIS OF SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS

专利号:EP-3087065-B1
优先权日:2013-12-23
标 题 :Synthesis of urolithins

专利号:CA-2972013-C
优先权日:2013-12-23
标题:Process-scale synthesis of urolithins

专利号:EP-3406142-B1
优先权日:2009-11-13
标题:Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis