CAS: 23945-44-0; 2,4-Dihydroxypyrimidine-5-Carboxylic Acid

上下游产品

2,4-dimethoxypyrimidine-5-carboxylic acid 5-cyanouracil 5-carboxylcytosine 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde 2,4-dioxohexahydropyrimidine-5-carboxylic acid 2,4-dichloropyrimidine-5-carboxylic acid uracil 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

胸腺嘧啶置于ammonium Iron(II) Sulfate,Pyruvate Kinase,Neurospora Crassa Thymine-7-Hydroxylase,Wild-Type,Full-Length,Residues 1-333,Succinyl-Coa Synthetase,His6-Tag Fused Protein,5'-三磷酸腺苷,辅酶 A,还原型辅酶ⅰ,Magnesium Chloride,维生素 C,L-Lactate Dehydrogenase体系中,用 Aq. Buffer 用作溶剂,化学反应生成脲嘧啶-5-羧酸
参考文献:Molecular Basis For The Substrate Specificity And Catalytic Mechanism Of Thymine-7-Hydroxylase In Fungi
标题:Molecular Basis For The Substrate Specificity And Catalytic Mechanism Of Thymine-7-Hydroxylase In Fungi
摘要:Tet蛋白在哺乳动物主动dna去甲基化过程中发挥着至关重要的作用,并在许多重要的细胞过程中发挥着重要作用.Tet蛋白催化5Mc向5Hmc,5Fc和5Cac的转化反应的化学原理与真菌核苷酸生物合成中胸腺嘧啶-7-羟化酶(t7H)催化t向5Hmu,5Fu和5Cau的转化反应相似.在这里,我们报道了neurospora Crassa T7H的晶体结构和生化特性.T7H仅在辅因子存在的情况下才能结合底物,并且不同底物的结合不会引起显著的构象变化.T7H对t和5Hmu表现出相当的结合亲和力,但对5Fu的亲和力低3倍.残基phe292,Tyr217和arg190在底物结合和催化中起着关键作用,底物c5修饰基团与辅因子和酶的相互作用有助于对不同底物的略有变化的结合亲和力和活性.催化后,产物被释放,新的辅因子和底物被重新加载以进行下一次氧化反应.我们的数据揭示了t7H底物特异性和催化机制的分子基础,并为tet蛋白底物识别和催化机制的分子机制提供了新的见解.
Doi:10.1093/nar/gkv979

专利信息

专利号:WO-2024042405-A1
优先权日:2022-08-26
标 题:Compositions and methods for the synthesis of bio-based polymers
发明人：OLIVEIRA ANA; CAPÊTO ANA PAULA; PINTADO MANUELA
权利人:AMYRIS BIO PRODUCTS PORTUGAL UNIPESSOAL LTDA; UNIV CATOLICA PORTUGUESA
摘要:The present disclosure provides compositions and methods for the synthesis of bio-based polymers (e.g., polyurethanes and polyesters) from secondary materials produced during a fermentation process. The disclosure also features intermediates produced during these processes, as well as compositions containing the same.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-11339145-B2
优先权日:2018-05-04
标题 :Synthesis of cerdulatinib
发明人：PANDEY ANJALI; SRAN ARVINDER; CHEN YING; POGGIALI DANIELE; FUMAGALLI TIZIANO
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides processes for the preparation of cerdulatinib, which is of formula I:or a salt thereof. The disclosure also provides intermediates and processes for the preparation of the intermediates useful in the preparation of cerdulatinib or a salt thereof.

专利号:US-12312376-B2
优先权日:2020-01-24
标 题:Therapeutic double stranded RNA and methods for producing the same
发明人：EQUELS THOMAS K; ATODARIA VISHWAJEETSINH M; SCOTT VICTORIA G; STRAYER DAVID R; RODINO PETER W
权利人:AIM IMMUNOTECH INC
摘要:Disclosed is a method for the synthesis of a therapeutic double-stranded RNA (tdsRNA), comprising: a) synthesizing a first single-stranded RNA (first ssRNA) in a first synthesis reaction with PNPase as the only RNA polymerase; b) synthesizing a second single-stranded RNA (second ssRNA) in a second synthesis reaction with PNPase as the only RNA polymerase; and c) hybridizing the first ssRNA with the second ssRNA to form the tdsRNA; wherein step a) and step b) are performed in any order. Also disclosed is a product produced by the method.

专利号:WO-2016193780-A1
优先权日:2015-05-29
标题:PROCESS FOR OBTAINING A HYPOGLYCEMIC PHARMACEUTICAL COMPOSITION BASED ON TiO2 NANOMATERIALS AND STEVIA REBAUDIANA BERTONI
发明人：MORENO-RODRÃ?GUEZ JOSÉ ALBINO
权利人:BENEMÉRITA UNIV AUTÓNOMA DE PUEBLA
摘要:A process to prepare Stevia Rebaudiana Bertoni (SrB) extract nanocapsules in TiO 2 nanomaterials, wherein it comprises the steps of: a) obtaining the separate synthesis of TiO 2 and TiO 2 nanomatrices to 30% volume concentration of the Stevia Rebaudiana Bertoni (SrB) extract by: b) preparing an homogeneous solution with a reflux system with constant stirring to obtain TiO 2 nanomatrices, labeled as TiO 2 -70; and c) preparing an homogeneous solution with a reflux system with constant stirring by adding 30% by volume of the SrB extract to the homogeneous solution to obtain the SrB/TiO 2 nanomatrices, labeled as SrB/TiO 2 -30-70.

专利号:US-2019337930-A1
优先权日:2018-05-04
标 题 :Synthesis of cerdulatinib