CAS: 22536-63-6; 2-Chloro-4-Methoxypyrimidine

相似化合物

13223-25-1 83774-09-8 43212-41-5

上下游产品

2,6-Dichloropyrimidine sodium methylate methanol potassium methanolate 4-methoxypyrimidine (4-methoxy-pyrimidin-2-yl)-hydrazine 5-(2-chloro-4-methoxypyrimidinyl)-1-phenylmethanol 2-((2R,3S)-3-Benzyloxy-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy)-4-methoxy-pyrimidine

2,4-二氯嘧啶置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应生成2-氯-4-甲氧基嘧啶
参考文献:Piperazine Compounds And Medicinal Use Thereof
标题:Piperazine Compounds And Medicinal Use Thereof
摘要:本发明涉及一种哌嗪化合物,其化学式为 其中r1和r2分别为氢,卤素,低烷基,低烷氧基,氨基,取代氨基,硝基,羟基或氰基,R3,R4和r5分别为氢,卤素,低烷基,低烷氧基,硝基,氨基,取代氨基或羟基,R6和r7分别为氢,低烷基,受卤素取代的低烷基,芳基烷基,酰基或受卤素取代的低酰基,R8和r9分别为氢或低烷基,Y为低烷基烯基等,环a为苯基,嘧啶基,噻唑基,吡啶基,吡啉基或咪唑基,其药学上可接受的盐及含有这些化合物的药物制剂.本发明的化合物具有优越的tnf-α产生抑制作用和/或il-10产生促进作用,由于它不含或仅显示对中枢神经系统有显著减少的作用,该化合物可用作高度安全和优越的tnf-α产生抑制剂和/或il-10产生促进剂,并可用作预防或治疗由异常tnf-α产生引起的各种疾病的药剂,例如可用于治疗可通过il-10治愈的慢性炎症性疾病,急性炎症性疾病,感染引起的炎症性疾病,自身免疫疾病,过敏性疾病和tnf-α介导的疾病.

专利信息

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:EP-1600451-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-l-nucleosides

专利号:JP-2003513984-A
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleoside

专利号:EP-1600452-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides

专利号:EP-1634888-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides