专利号:US-2024010638-A1 优先权日:2020-11-13 标题:Improved synthesis of crac channel inhibitors 发明人:STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY 权利人:CALCIMEDICA INC 摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.
专利号:US-10081610-B2 优先权日:2014-09-12 标题 :Efficient and scalable synthesis of 2-(1′h-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs 发明人:SONG JIASHENG; ZHANG SUOMING; LI GUODONG; YANG LUQUING 权利人:ARIAGEN INC 摘要:Methods of synthesizing 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include condensation reactions or condensation and oxidation reactions to form the thiazoline or thiazole moiety of ITE or its structural analogs.
专利号:WO-2014188385-A3 优先权日:2013-05-23 标 题:Bromination of arylene dianhydrides 发明人:GOVINDARAJU THIMMAIAH; VENKATA SUSEELA YELISETTY 权利人:JNCASR BANGALORE 摘要:The present disclosure relates to a process for bromination of arylene dianhydrides, particularly1,4,5,8-naphthalenetetracarboxylic dianhydride (NDA) using 5,5-dimethyl-1,3- dibromohydantoin (DBH) or tribromoisocyanuric acid (TBCA) as brominating agent. The disclosure further relates to condensation of the brominated dianhydrides with amines to yield corresponding imides, particularly naphthalene diimides (NDI) which are versatile precursors for the synthesis of core functionalized naphthalene diimides. The present disclosure further relates to the use of DBH or TBCA as brominating agents for brominating arylene dianhydride, particularly naphthalene tetracarboxylic dianhydride.
专利号:US-2016168138-A1 优先权日:2013-07-15 标题:Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant 发明人:IQBAL JAVED; DAHANUKAR VILAS HARESHWAR; ORUGANTI SRINIVAS; KANDAGATLA BHASKAR 权利人:REDDY S LAB LIMTED DR 摘要:A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)
专利号:US-12006291-B2 优先权日:2022-01-11 标 题 :Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid 发明人:ZHU KAICHENG; WANG TAO; ZHANG JIAJUN; CAO HUI; SHEN RUICHAO; WANG GUOQIANG; WU GEORGE G; OR YAT SUN 权利人:ENANTA PHARM INC 摘要:The present invention relates to processes for preparing a Compound (1): n nor a pharmaceutically acceptable salt or solvate thereof. Compound (1) is useful as in many pharmaceutical agents, especially is useful as key intermediate in the synthesis of certain SARS-CoV-2 3CLpro inhibitors.
专利号:WO-2011064249-A1 优先权日:2009-11-25 标题 :Synthesis of acetoxyacetaldehyde