CAS: 17306-46-6; 7-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-5-Hydroxy-2-(4-Hydroxyphenyl)-4H-Chromen-4-One

该化合物是Rutaceae家族,其化学结构的特点是,它的化学结构由富兰藤脊组成,配有糖味,典型的甘蓝.Rhoifolin展示了一系列的生物活动,包括抗氧化剂,抗炎和潜在的抗癌特性,这使它成为药理研究的兴趣.其溶解性一般在极地溶剂中比较中,根据环境条件,例如pH和温度,它可能表现出不同程度的稳定.此外,Rhoifolin在传统草药中的存在突出其潜在的治疗用途.与许多氟芳素一样,它也可能有助于发现植物的颜色和口味.目前正在进行进一步的研究,以充分阐明其作用和潜在健康惠益的机制.

结构式图片

上下游产品

naringin4',5-diacetoxy-7-[hexa-O-acetyl-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyl)oxy]flavone 3'-nitrorhoifolin 3'-nitroacacetin 3'-nitroapigenin

合成工艺路线路线简述

  • 合成目标产物 Rhoifolin 主要起始原料 Naringin
  • (文献来源)合成步骤主要原料 Naringin
📜柚皮苷置于碘体系中,用 吡啶 用作溶剂,化学反应 8.0H,以82%的收率获得野漆树苷
参考文献:一种将黄烷酮转化为黄酮的简单方法1)
标题:一种将黄烷酮转化为黄酮的简单方法1)
摘要:黄烷酮可以在碱性溶液中与碘一起转化为黄酮.羟基不需要保护.在糖苷的情况下,这种简化还包括糖的 H2O 基团.
Doi:10.1002/ardp.19833160307

专利信息


专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人:ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人:ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:CN-110408649-B
优先权日:2019-07-25
标题:Application of NOR gene and its encoded protein in regulating the synthesis of flavonoids in tomato fruit

专利号:CN-110408649-A
优先权日:2019-07-25
标题:Application of the protein of NOR gene and its coding in regulation tamato fruit in flavonoids synthesis

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Liu Y, Jin Z, Sun D, Zheng J, Xu B, Lan T, Zhao Q, He Y, Li J, Zhang Y, Cui Y. Preparation of monoclonal antibody against rhoifolin and its application in enzyme-linked immunosorbent assay of rhoifolin and diosmin. Talanta. 2024 Sep 11;281:126871. doi: 10.1016/j.talanta.2024.126871. Epub ahead of print. 16(16):2619. doi: 10.3390/nu16162619.
3: Sharanya CS, Wilbee DS, Sathi SN, Natarajan K. Computational screening combined with well-tempered metadynamics simulations identifies potential TMPRSS2 inhibitors. Sci Rep. 2024 Jul 13;14(1):16197. doi: 10.1038/s41598-024-65296-7.
4: Al-Shalabi E, Sunoqrot S, Al-Zuhd T, Alshehada RS, Ibrahim AIM, Hammad A. Exploring the Antioxidant and Anti-inflammatory effect of Rhoifolin Extracted from Teucrium polium in Rats' Lungs Exposed to Tobacco Smoke. Chem Biodivers. 2024 Jul

合成参考文献


参考文献:10.1021/np300460a
摘要:Lewin G, Maciuk A, Moncomble A, Cornard JP. Enhancement of the water solubility of flavone glycosides by disruption of molecular planarity of the aglycone moiety. J Nat Prod. 2013 Jan 25;76(1):8–12. doi: 10.1021/np300460a.
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