CAS: 15366-08-2; Sec-Butylmagnesium Chloride

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CAS号78-86-4 2-氯丁烷 | CAS号7439-95-4 镁标准溶液 | CAS号3404-72-6 2,3-二甲基-1-戊烯 | CAS号1595-06-8 1-sec-Butyl-2-m... | CAS号2362-50-7 噻蒽5-氧化物 | CAS号583-48-2 3,4-二甲基己烷 | CAS号92-85-3 噻蒽 | CAS号106-97-8 丁烷 | CAS号17964-31-7 butyl(diphenyl)... | CAS号18379-40-3 butan-2-yl(dich... | CAS号106-98-9 正丁烯 | CAS号624-64-6 反-2-丁烯

氯代仲丁烷置于magnesium体系中,用 氘代四氢呋喃 用作溶剂,80.0 °C,689.49 Kpa 条件下,以89%的收率获得仲丁基氯化镁
参考文献:一次性弹药筒概念可按需合成turbo Grignards,Knochel-Hauser酰胺和烷氧基镁.
标题:一次性弹药筒概念可按需合成turbo Grignards,Knochel-Hauser酰胺和烷氧基镁.
摘要:镁有机金属试剂在有机合成中占据中心位置.这些化合物的新鲜度是实现高转化率和可再现结果的关键.由金属镁合成格氏试剂的常用方法存在安全性问题,并且批次间存在差异.固体试剂与溶液相试剂相结合的管状反应器可实现有机镁试剂的连续流制备.据报道,使用镁金属和氯化锂的分层填充床柱来合成高浓度涡轮格氏试剂.一种低成本的吊舱式合成器原型,其中包括一次性使用的预包装全氟化药筒和试剂袋,用于按需实验室规模自动合成碳,氮,并介绍了氧涡轮镁碱.该概念将使人们能够以发现规模获得新鲜的有机镁试剂,并且与操作者在流动和/或有机金属化学领域的经验无关.
Doi:10.3762/bjoc.16.115

专利信息

专利号:US-6340751-B1
优先权日:1998-07-24
标 题 :Process for the preparation of 4-substituted azetidinone derivatives
发明人：SAITO TAKAO; MURAYAMA TOSHIYUKI; MATSUMOTO TAKAJI; MIURA TAKASHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): n and (IV): n represented by the following formula (III): n n n MgR 5 R 6   (III) n n n wherein R 5 represents a C 1-12 alkyl group, a C 2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C 1-4 alkyl group, a phenyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom, and R 6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR 7 group (R 7 representing a lower C 1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-β′ configuration.

专利号:US-12172982-B2
优先权日:2020-08-12
标 题:Synthesis of quinazoline compounds
发明人：LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

专利号:US-12071422-B2
优先权日:2022-02-07
标 题 :Process for synthesis of quinazoline compounds
发明人：LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

专利号:US-2010047841-A1
优先权日:2007-02-27
标 题 :Synthesis of desacetoxytubulysin h and analogs thereof
发明人：WIPF PETER; WANG ZHIYONG
权利人:UNIV PITTSBURGH
摘要:Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as conditions and disorders related to uncontrolled cell growth: n n n n n n n n n n wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are described herein.

专利号:US-2023416243-A1
优先权日:2020-11-06
标 题 :Process for Preparing Heterocyclic Methanone Compounds and AZA-Bicyclo Intermediates Thereof
发明人：GRUGEL CHRISTIAN
权利人:ACTINOGEN MEDICAL LTD
摘要:The present disclosure relates to a process for synthesis of heterocyclic methanone compounds, and in particular 3′-substituted, 3-hydroxyl-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds, and aza-bicyclo intermediates thereof. In particular, the present disclosure also relates to a process for the synthesis of Xanamem. The present disclosure also relates to a process for the synthesis of optionally protected aza-bicyclo intermediate compounds. The present disclosure also relates to 3′-substituted, 3-hydroxyl-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and aza-bicyclo intermediate compounds thereof.

专利号:US-8207337-B2
优先权日:2007-01-29
标 题:Reagent for organic synthesis reaction containing organic triol borate salt
发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).