CAS: 139-06-0; Calcium Bis(Cyclohexylsulphamate)
该化合物是环球家族的合成甜食器,是环球酸的钙盐,主要用作各种食品和饮料中的非营养甜食器.这种化合物以其高糖度闻名,比苏格罗斯高数百倍的糖,使其成为一个有效的糖替代品. 钙环球产物通常是白色,晶体和溶液,有利于将其融入液体配方. 它在热量下稳定,具有中性口味特征,适合多种用途,包括面包和软饮料.然而,由于担心可能对健康产生影响,导致某些地区的限制或禁令,因此,它的使用受到一些国家的监管监督.
物理性质
- PSA:155.22
- LogP:3.6812
- 溶解性Form: crystals; pleasant, very sweet taste; practically insol in alcohol, benzene, chloroform, ether; pH of 10% aq soln 5.5-7.5; Said to be more resistant to cooking temp than saccharin /Dihydrate/ | ODORLESS; WHITE CRYSTALLINE POWDER; 1 G SOL IN 4 ML WATER; 1 G SOL IN 60 ML ETHANOL; 1 G SOL IN 1.5 ML PROPYLENE GLYCOL; LOSS ON DRYING @ 140 °C FOR 2 HR 9.0% MAX /DIHYDRATE/; IN DILUTE SOLN ABOUT 30 TIMES AS SWEET AS SUCROSE | SOL IN AQ SOLN OF SORBITOL; 25 G SOL IN 100 ML 25% ALCOHOL; 2.4 G SOL IN 100 ML 90% ETHYL ALCOHOL | Soluble in water. Insoluble in most organic solvents.
- 敏感性140°C2h失去结晶水，至500°C时分解。味甚甜，其稀溶液的甜度约为蔗糖的30倍。10%水溶液的Ph值为5.5～7.5，对热、光、空气均甚稳定。加热后有苦味，在水溶液中呈钙离子强电解质，易与果汁中的有机酸之类作用，亦可使乳中蛋白凝固。鉴别试验：溶于水，略溶于乙醇。按OT-42方法测定。在1%的试样液10ml中加入盐酸1ml，混合，加氯化钡试液(TS-37)1ml。所得溶液仍应澄明，如再加亚硝酸钠试液(TS-226)1ml，则有白色沉淀形成。钙试验阳性(IT-10)。含量分析：精确称取试样约0.4g，溶于由50ml水和5ml稀盐酸试液(TS-117)配成的混合液中，用0.1mol/L亚硝酸钠滴定。当滴定至最后1ml滴定液时，应逐滴加入，其终点由粘有碘化淀粉试纸的玻璃棒伸入被滴定液中时立即出现蓝色为止，或用电位滴定法确定终点。当滴定完全时，被滴液维持1min后仍能重现上述终点现象。每Ml 0.1mol/L亚硝酸钠液相当于环己基氨基磺酸钙(C12H24CaN2O6S2)19.83mg，以干基计。
- 外观形态白色晶体
- 储存条件库房低温通风干燥环境
- 产品应用环己基氨基磺酸钙(139-06-0)的用途:无营养型甜味剂.
- 性质描述环己基氨基磺酸钙(139-06-0)的性状:白色结晶或结晶性粉末.几乎无臭.140°C2h失去结晶水,至500°C时分解.味甚甜,其稀溶液的甜度约为蔗糖的30倍.10%水溶液的pH值为5.5～7.5,对热,光,空气均甚稳定.加热后有苦味,在水溶液中呈钙离子强电解质,易与果汁中的有机酸之类作用,亦可使乳中蛋白凝固.易溶于水(lg/4ml),微溶于乙醇(lg/60ml),溶于丙二醇(Lg/1.5ml),几乎不溶于苯,氯仿和乙醚.
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Warning(警告)
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
- UN编号25kgs
- 危险品标志Xn
- 安全声明26-36
- 危险类别码R36/37/38
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
专利信息
专利号:US-12239620-B2
优先权日:2021-05-28
标题 :Methods to decrease triglyceride synthesis in the liver
发明人：MATSUDA KAZUKO; OGURA MASATSUNE
权利人:MEDICINOVA INC
摘要:Described herein are methods for decreasing triglyceride synthesis and/or decreasing triglyceride accumulation in the liver of a subject, wherein the methods comprise administering to the subject a compound of Formula (I):a metabolite thereof, or a pharmaceutically acceptable salt thereof.
专利号:CN-117320701-A
优先权日:2021-05-28
标 题 :Method for reducing synthesis of triglyceride in liver
专利号:AU-2002360678-B2
优先权日:2001-12-18
标题 :Composition, synthesis, and therapeutic applications of polyamines
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:HOO D, HU C-C; ANAL CHEM 44(12) 2111 (1972)
摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 631
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
摘要:IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work).
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