CAS: 101932-71-2; Calyculin A From Discodermia Calyx

📜[(2R,3R,5R,7R,8R,9S)-7-[tert-Butyl(Dimethyl)Silyl]Oxy-2-[(1S)-2-[(4S,5S,6R)-6-[(2R,3E,5E,7E,9Z)-10-Cyano-4,5,9-Trimethyldeca-3,5,7,9-Tetraen-2-Yl]-2,2,5-Trimethyl-1,3-Dioxan-4-Yl]-1-Methoxyethyl]-9-[(E)-3-[2-[(2S)-4-[[(2S,3S,4S)-4-(Dimethylamino)-5-Methoxy-2,3-Bis(Triethylsilyloxy)Pentanoyl]Amino]Butan-2-Yl]-1,3-Oxazol-4-Yl]Prop-2-Enyl]-4,4,8-Trimethyl-1,10-Dioxaspiro[4.5]Decan-3-Yl] Bis(2-Trimethylsilylethyl) Phosphate置于氢氟酸体系中,用 水,乙腈 用作溶剂,以57%的收率获得蛋白磷酸酯酶抑制剂
参考文献:Tanimoto,Norihiko; Gerritz,Samuel W.; Sawabe,Akiyoshi,Angewandte Chemie,1994,Vol. 106,# 6,P. 674-677
标题:Tanimoto,Norihiko; Gerritz,Samuel W.; Sawabe,Akiyoshi,Angewandte Chemie,1994,Vol. 106,# 6,P. 674-677

专利信息

专利号:US-7339066-B1
优先权日:2006-05-31
标题 :Intermediates for the synthesis of polypropionate antibiotics
发明人：PARKER KATHLYN; CAO HUANYAN
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The invention relates to intermediate compounds of the formula n nwherein R 1 is H or a protecting group, R 2 and R 3 each independently represent H, methyl, or a leaving group, provided that at least one, but not both, of R 2 and R 3 is a leaving group. The intermediate compounds are useful for the synthesis of discodermolide, its derivatives, and related compounds.

专利号:US-2007282121-A1
优先权日:2006-05-31
标 题 :Intermediates for the synthesis of polypropionate antibiotics

专利号:US-8883763-B2
优先权日:2010-03-01
标题 :Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same
发明人：POPOV ANDREI; JUHEM AURÉLIE; FLORENT JEAN-CLAUDE; N GUYEN CHI-HUNG
权利人:POPOV ANDREI; JUHEM AURÉLIE; FLORENT JEAN-CLAUDE; N GUYEN CHI-HUNG; UNIV JOSEPH FOURIER; CENTRE NAT RECH SCIENT; INST CURIE
摘要:The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer.

专利号:EP-4058432-A1
优先权日:2019-11-14
标 题:Improved synthesis of kras g12c inhibitor compound

专利号:US-7297807-B1
优先权日:2006-05-31
标题:Intermediates for the synthesis of polypropionate antibiotics

专利号:US-2018117029-A1
优先权日:2016-11-03
标 题 :Targeting Metabolic Vulnerability in Triple-Negative Breast Cancer
发明人：TOKER ALEX; BROWN KRISTIN K
权利人:BETH ISRAEL DEACONESS MEDICAL CT INC
摘要:Methods for treating cancer in a subject by administering a therapeutically effective amount of a pyrimidine synthesis inhibitor and a genotoxic chemotherapeutic agent. In some embodiments, the cancer is triple negative breast cancer.