CAS: 953-91-3; Cyclohexyl 4-Methylbenzenesulfonate

该化合物是一个有机化合物,其特点是其全氟辛烷磺酸酯结构,其特点是一个环己基组,附于一个聚二苯乙烯硫酸混合物,该混合物有助于其反应性和溶性特性.该化合物一般没有色素,可用作有机合成的试剂,特别是在形成碳-碳债券和作为酒精保护组中使用.Cyclohexyl p-tolunesultate在二氯甲烷和乙醚等有机溶剂中是可溶性可溶的.该化合物在标准条件下相对稳定,但应谨慎处理,因为潜在刺激性特性.与许多磺酸酯一样,它可以在水中进行水解,导致环己醇和聚氨酸的释放.在与该化合物一起工作时,应观察适当的安全措施,包括使用个人防护设备和适当的通风.

结构式图片

物理性质

MSDS等安全信息

上下游产品

p-toluenesulfonyl chloride cyclohexanol cyclohexyl azoxytosylate hexanebicyclo3.1.0hexane2-cyclohexyl-p-xylene 2,5-dicyclohexyl-p-xylene 1,3-dimethyl-4-cyclohexylbenzene cyclohexyl azide

合成工艺路线路线简述

  • 108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; Rt; 2 H,Rt
    标题:Quinazolinone Parp-1/2 Inhibitor Containing Piperazinone And Preparation Method,And Application As Antitumor Agents
    参考文献:China]

    104-15-4 + 398477-63-9 = 953-91-3
    反应条件:1.1 Solvents: Dichloromethane
    标题:Synthesis Of Alkyl Sulfonates From Sulfonic Acids Or Sodium Sulfonates Using Solid-Phase Bound Reagents
    作者:Vignola,N.; Dahmen,S.; Enders,D.; Brase,S.
    参考文献:Tetrahedron Letters 日期:2001 卷标:42(44) 页码:7833-7836]

    108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Potassium Hydroxide; 5 Min,Rt1.2 Reagents: Potassium Carbonate; 3 Min,> Rt
    标题:Chemoselective And Scalable Preparation Of Alkyl Tosylates Under Solvent-Free Conditions
    作者:Kazemi,Foad; Massah,Ahmad R.; Javaherian,Mohammad
    参考文献:Tetrahedron 日期:2007 卷标:63(23) 页码:5083-5087]

    23730-24-7 = 953-91-3 [标题:Reaction Conditions
    标题:Preparation Of Unstable Tosylates
    作者:Coates,Robert M.; Chen,Judy Pei-Yin
    参考文献:Tetrahedron Letters 日期:1969 卷标:(32) 页码:2705-8]

    108-93-0 = 953-91-3
    反应条件:1.1 Catalysts: Indium Solvents: Acetonitrile; 4.5 H,Reflux
    标题:Mild And Efficient Indium Metal Catalyzed Synthesis Of Sulfonamides And Sulfonic Esters
    作者:Kim,Joong-Gon; Jang,Doo Ok
    参考文献:Synlett 日期:2007 卷标:(16) 页码:2501-2504]

    16722-51-3 + 108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Triphenylphosphine,Diethyl Azodicarboxylate,Diisopropyl Azodicarboxylate Solvents: Benzene
    标题:The Mitsunobu Reaction
    作者:Hughes,David L.
    参考文献:Organic Reactions (Hoboken 日期:1992 卷标:42]

    13871-89-1 = 953-91-3
    反应条件:1.1 Catalysts: Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(Oh)2O10.Xh2O),Iron Chloride (Fecl3) Solvents: Acetonitrile; 10 H,Reflux
    标题:An Efficient One-Pot Conversion Of Thp And Tms Ethers To Sulfonate Esters Using Fecl3-Montmorillonite K-10 Clay
    作者:Movassagh,Barahman; Shokri,Salman
    参考文献:Zeitschrift Fuer Naturforschung 日期:2005 卷标:60(7) 页码:763-765]

    108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: 1H-Imidazolium,3-[4-[3-[3-(Ethoxydihydroxysilyl)Propyl]-1H-Imidazolium-1-Yl]But... Solvents: Water; Rt
    标题:Ionic Liquid Brush As An Efficient And Reusable Heterogeneous Catalytic Assembly For The Tosylation Of Phenols And Alcohols In Neat Water
    作者:Feng,Simin; Li,Jing; Wei,Junfa
    参考文献:New Journal Of Chemistry 日期:2017 卷标:41(12) 页码:4743-4746]

    108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Triethylamine,1-Methylimidazole Solvents: Toluene; 1 H,20 - 25 °C
    标题:N-Methylimidazole
    作者:Tindall,Craig; Ladd,Carolyn L.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2014 卷标:1 页码:1-13]

    108-93-0 = 953-91-3
    反应条件:1.1 Catalysts: Tungstate(3-),Tetracosa-μ-Oxododecaoxo[μ12-[phosphato(3-)-Ko:Ko:Ko:Ko′:Ko′:Ko′:...; 6 Min,Rt
    标题:Solvent-Free And Selective Tosylation Of Alcohols And Phenols With P-Toluenesulfonyl Chloride By Heteropolyacids As Highly Efficient Catalysts
    作者:Fazaeli,Razieh; Tangestaninejad,Shahram; Aliyan,Hamid
    参考文献:Canadian Journal Of Chemistry 日期:2006 卷标:84(5) 页码:812-818]

    104-15-4 + 108-93-0 = 953-91-3
    反应条件:1.1 Catalysts: Silica Solvents: Dichloromethane; 1 H,Reflux
    标题:An Efficient And Selective Tosylation Of Alcohols With P-Toluenesulfonic Acid
    作者:Das,Biswanath; Reddy,V. Saidi; Reddy,M. Ravinder
    参考文献:Tetrahedron Letters 日期:2004 卷标:45(36) 页码:6717-6719]

    104-15-4 + 108-93-0 = 953-91-3
    反应条件:1.1 Catalysts: Cobalt Chloride (Cocl2) Solvents: 1,2-Dichloroethane; 1 H,80 °C
    标题:Cobalt(Ii)-Catalyzed Tosylation Of Alcohols With P-Toluenesulfonic Acid
    作者:Velusamy,Subbarayan; Kumar,J. S. Kiran; Punniyamurthy,T.
    参考文献:Tetrahedron Letters 日期:2004 卷标:45(1) 页码:203-205]

    104-15-4 + 398477-63-9 = 953-91-3
    反应条件:1.1 Solvents: Dichloromethane; 4 H,Rt
    标题:Efficient Synthesis Of Sulfonic,Phosphoric,And Phosphinic Esters Employing Alkylating Polymer-Bound Reagents
    作者:Vignola,Nicola; Dahmen,Stefan; Enders,Dieter; Brase,Stefan
    参考文献:Journal Of Combinatorial Chemistry 日期:2003 卷标:5(2) 页码:138-144]

    108-93-0 = 953-91-3
    反应条件:1.1 Solvents: Pyridine; 0 °C -> Rt; 24 H,Rt
    标题:Enantioselective Seleno-Michael Addition Reactions Catalyzed By A Chiral Bifunctional N-Heterocyclic Carbene With Noncovalent Activation
    作者:Li,En; Chen,Jiean; Huang,Yong
    参考文献:Angewandte Chemie 日期:2022 卷标:61(23)]

    108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Tetrabutylammonium Chloride Catalysts: Trichloroisocyanuric Acid Solvents: Acetonitrile,Water; 1 - 2 Min,0 °C; 30 Min,0 °C1.2 Reagents: Triethylamine; 1 - 2 Min,0 °C; 90 Min,Rt
    标题:One-Pot Tandem Reactions For Direct Conversion Of Thiols And Disulfides To Sulfonic Esters,And Paal-Knorr Synthesis Of Pyrrole Derivatives Catalyzed By Tcca
    作者:Hemmati,Saba; Mojtahedi,Mohammad Majid; Abaee,Mohammad Saeid; Vafajoo,Zahra; Saremi,Shokufe Ghahri; Et Al
    参考文献:Journal Of Sulfur Chemistry 日期:2013 卷标:34(4) 页码:347-357]

    108-93-0 = 953-91-3
    反应条件:1.1 Catalysts: Copper Oxide (Cuo) Solvents: Acetonitrile; 2 H,Rt
    标题:A Simple And Efficient Method For Sulfonylation Of Amines,Alcohols And Phenols With Cupric Oxide Under Mild Conditions
    作者:Meshram,G. A.; Patil,Vishvanath D.
    参考文献:Tetrahedron Letters 日期:2009 卷标:50(10) 页码:1117-1121]

    104-15-4 + 108-93-0 = 953-91-3
    反应条件:1.1 Reagents: Iron (Exchanged Montmorillonite Clay) Solvents: 1,2-Dichloroethane
    标题:Montmorillonite Clay Catalyzed Tosylation Of Alcohols And Selective Monotosylation Of Diols With P-Toluenesulfonic Acid: An Enviro-Economic Route
    作者:Choudary,B. M.; Chowdari,N. S.; Kantam,M. L.
    参考文献:Tetrahedron 日期:2000 卷标:56(37) 页码:7291-7298]

    108-93-0 = 953-91-3
    反应条件:1.1 Solvents: Pyridine; 0 °C; 12 H,Rt
    标题:Design,Synthesis,And Functional Assessment Of Cmpd-15 Derivatives As Negative Allosteric Modulators For The β2-Adrenergic Receptor
    作者:Meng,Kaicheng; Shim,Paul; Wang,Qingtin; Zhao,Shuai; Gu,Ting; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2018 卷标:26(9) 页码:2320-2330]

    108-93-0 = 953-91-3
    反应条件:1.1 Solvents: Pyridine; Rt; 8 H,Rt
    标题:Preparation Of Pyrazole Compounds As Antitumor Agent
    参考文献:China]

    4124-41-8 + 108-93-0 = 953-91-3
    反应条件:1.1 Solvents: Water; 15 Min,110 °C
    标题:Catalyst-Free Tosylation Of Lipophilic Alcohols In Water
    作者:Oliverio,Manuela; Costanzo,Paola; Paonessa,Rosina; Nardi,Monica; Procopio,Antonio
    参考文献:Rsc Advances 日期:2013 卷标:3(8) 页码:2548-2552
📜对甲苯磺酰氯 以 吡啶,水,环己醇 作为反应溶剂,化学反应生成 P-甲苯磺酸环己酯
参考文献:Heat-Sensitive Image Recording Medium And Process
标题:Heat-Sensitive Image Recording Medium And Process

海关参考信息

专利信息


专利号:WO-2013014486-A1
优先权日:2011-07-28
标题:Improved synthesis of 2-(4-(4-chlorophenyl) cyclohex-1-enyl) -3, 4-dihydronaphthalen-1 (2h)-one; an intermediate for atovaquone
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI AUNRAG
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI AUNRAG
摘要:A process for preparation of 2-(4-(4-chlorophenyl) cyclohex-l-enyl)-3,4-dihydronaphthalen- 1(2H)-one (V), key intermediate for synthesis of Atovaquone [I]. The process for preparation of compound(V) comprising of the steps of; i) Reaction of 2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen- 1(2H)-one (IV) with trifluro acetic anhydride in presence of base in organic solvent to yield compound of formula (XIa) ii) Elimination of trifluoroacetyl functionality of compound (XIa) in organic solvent and in presence of organic base to give compound of formula (V). The invention also provides a Process for preparation of compound(XIa) comprising of the steps of; i) reaction of 2-(4-(4-chlorophenyl)-l-hydroxy cyclohexyl)-3,4-dihydronaphthalen- 1(2H)-one (IV) with trifluro acetic anhydride in presence of organic base in organic solvent. A further process is provided for preparation of compound(V) from compound (XIa) comprising elimination reaction of trifluoroacetyl functionality compound (XIa) in organic solvent and in presence of organic base.

专利号:US-9895454-B2
优先权日:2014-07-03
标题:Metal oxide catalyzed radiofluorination
发明人：SERGEEV MAXIM; MORGIA FEDERICA; VAN DAM ROBERT MICHAEL; LAZARI MARK
权利人:UNIV CALIFORNIA
摘要:Inter alia, the first titania-catalyzed [ 18 F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [ 18 F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.

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合成参考文献


摘要:Wicha, J., Science of Synthesis, (2009) 48, 181.
摘要:Singh, F. V.; Wirth, T., Science of Synthesis Knowledge Updates, (2015) 2, 424.
摘要:Zhang, F.-L.; Wang, Y.-F., Science of Synthesis, (2021) , 408.
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