CAS: 88-17-5; 2-(Trifluoromethyl)Aniline

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CAS号384-22-5 2-硝基-Alpha,Alph... | CAS号2314-97-8 三氟碘甲烷 | CAS号445-03-4 2-氨基-5-氯三氟甲苯 | CAS号56-37-1 三乙基苄基氯化铵(TEBAC) | CAS号393-11-3 4-硝基-3-三氟甲基苯胺 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号615-36-1 2-溴苯胺 | CAS号75-63-8 三氟溴甲烷 | CAS号95-51-2 2-氯苯胺 | CAS号320-31-0 4-溴-2-(三氟甲基)苯甲酸 | CAS号39630-24-5 [2-(吗啉-4-羰基)苯基]胺 | CAS号344-62-7 2'-(三氟甲基)乙酰苯胺 | CAS号35853-41-9 2,8-双(三氟甲基)-4-羟基喹啉 | CAS号39630-25-6 (2-氨基苯基)-(1-哌啶)甲酮 | CAS号394-70-7 4-氟喹啉 | CAS号25753-22-4 2,4,6-三(三氟甲基)苯胺 | CAS号367-71-5 2,4-双(三氟甲基)苯胺 | CAS号317-57-7 8-三氟甲基喹啉 | CAS号606-46-2 N,N-二乙基邻甲苯胺

N-苯基吡啶甲酰胺置于盐酸,Dipotassium Peroxodisulfate,Copper(I) Bromide体系中,用 乙醇,乙腈 作为反应溶剂,化学反应 24.0H,反应生成 邻氨基三氟甲苯
参考文献:协调活化策略诱导的苯胺选择性ch三氟甲基化
标题:协调活化策略诱导的苯胺选择性ch三氟甲基化
摘要:通过协调活化策略,开发了一种简单的合成2-(三氟甲基)苯胺衍生物的方案.反应显示出非常好的反应性,并以中等至非常好的收率获得产物目标产物.令人愉悦的是,可以以优异的产率回收指导基团.此外,该策略允许有效地获得氟他芬宁的合成.有人提出单电子转移机制负责该三氟甲基化反应.
DOI:10.1002/cctc.201701596

专利信息

专利号:US-5811586-A
优先权日:1996-05-29
标 题 :Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine
发明人：CANNATA VINCENZO; GALBIATI BARBARA; SPREAFICO ANGELO
权利人:ALFA CHEM ITAL
摘要:A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.

专利号:US-6747175-B2
优先权日:2000-03-01
标 题:Chlorination of an aniline in a hydrofluoric medium
发明人：KEMPF HUBERT; GUIDOT GILBERT; SAINT-JALMES LAURENT
权利人:RHODIA CHIMIE SA
摘要:The invention concerns a method for the synthesis of chlorinated aniline on the ring and comprising at least a sp3 hybridization carbon atom both perhalogenated and bearing a fluorine atom. Said method is characterized in that it comprises a step which consists in chlorinating a precursor aniline of said chlorinated aniline, said chlorination being carried out in a hydrofluoric medium capable of exchanging chlorine and fluorine in benzyl position. The invention is useful for the synthesis of organofluorinated and/or chlorinated compounds.

专利号:US-7271231-B2
优先权日:1995-01-24
标 题 :Polymerization of olefins
发明人：BROOKHART MAURICE S; JOHNSON LYNDA KAYE; KILLIAN CHRISTOPHER MOORE
权利人:DU PONT
摘要:Disclosed herein are processes for polymerizing ethylene, acyclic olefins, and/or selected cyclic olefins, and optionally selected olefinic esters or carboxylic acids, and other monomers. The polymerizations are catalyzed by selected transition metal compounds, and sometimes other co-catalysts. Since some of the polymerizations exhibit some characteristics of living polymerizations, block copolymers can be readily made. Many of the polymers produced are often novel, particularly in regard to their microstructure, which gives some of them unusual properties. Numerous novel catalysts are disclosed, as well as some novel processes for making them. The polymers made are useful as elastomers, molding resins, in adhesives, etc. Also described herein is the synthesis of linear α-olefins by the oligomerization of ethylene using as a catalyst system a combination a nickel compound having a selected α-diimine ligand and a selected Lewis or Bronsted acid, or by contacting selected α-diimine nickel complexes with ethylene.

专利号:US-4020052-A
优先权日:1975-11-25
标题 :Treatment of aromatic amines with gas mixtures derived from the oxidation of ammonia to effect diazotization/coupling
发明人：DETRICK JOHN KENT
权利人:DU PONT
摘要:1,3-Diaryl triazenes, e.g., 1,3-diphenyltriazene, intermediates in the synthesis of aromatic diamines, e.g., p-phenylenediamine, are prepared by catalytically oxidizing ammonia, and subsequently the resulting nitric oxide, with a gas comprising diluted molecular oxygen, e.g., air, so as to produce a gas mixture containing dilute NOx, i.e., NO2 preferably admixed with NO, x being (1 + n), wherein n is the NO2 fraction of the NOx; and contacting the gas mixture, preferably at a temperature in the range of about from 25 DEG to 350 DEG C., with excess primary aromatic monoamine, e.g., aniline, so as to result in a monoamine temperature in the range of about from 25 DEG to 90 DEG C., preferably 40 DEG to 60 DEG C., during contact. Highest yields of triazene are obtained when the x in NOx is about from 1.3 to 1.7, and the amount of NOx gas mixture contacted with the monoamine and the time of contact are such that at least about 60% by weight of the monoamine remains unconsumed. A gas mixture temperature just prior to gas contact with the liquid monoamine in the range of about from 110 DEG to 275 DEG C. is more preferred under certain circumstances.

专利号:US-2004267028-A1
优先权日:2001-09-24
标题 :Preparation and use of pyrrole derivatives for treating obesity
发明人：SMITH ROGER A; KLUENDER HAROLD C; SU NING; LAVOIE RICO C; FAN JIANMEI
权利人:SMITH ROGER A; KLUENDER HAROLD C; SU NING; LAVOIE RICO C; FAN JIANMEI
摘要:This invention relates to pyrrole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-4876376-A
优先权日:1983-06-23
标题 :Process for the halogenation, nitration and fluorination of aromatic derivatives
发明人：DESBOIS MICHAEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the halogenation (bromination or chlorination)/nitration/fluorination of aromatic derivatives substituted by at least one group containing a halogenoalkyl unit. The aromatic derivative is reacted with a halogen and a nitrating agent in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.