CAS: 86169-24-6; (R)-2-Amino-2-(2-Chlorophenyl)Acetic Acid

该化合物是一种非蛋白性非蛋白性氨基酸衍生物,具有氯苯替代成分,加强了其在非对称合成和制药应用中的用途,其立体化学纯度使其作为制造抗生素纯化化合物,特别是开发活性药物成分(APIs)和手性催化剂的构件,具有宝贵价值;氯基质的存在为进一步功能化提供了额外的再活动,而甘基因骨则确保与peptide联动方法的兼容性.该化合物通常用于药用化学研究,其结构特征有助于更有选择性和效能地设计生物活性分子.

英文名称(R)-2-Amino-2-(2-Chlorophenyl)Acetic Acid
中文名称(R)-2-氨基-2-(2-氯苯基)乙酸
IUPAC名称(R)-2-amino-2-(2-chlorophenyl)acetic acid
其它别名(R)-2-氯苯甘氨酸; D-2-Chlorophenylglycine
CAS编号86169-24-6
MFCD编号:MFCD03426347
EINECS号:672-350-8
FDA UNII编号:777ZTP39LZ
分子式:C8H8ClNO2
分子量:185.61
产品CID: 1862746
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: LMIZLNPFTRQPSF-SSDOTTSWSA-N
InChI=1S/C8H8ClNO2/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m1/s1…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

欧盟法规

C&L通报

上下游产品

CAS号143-33-9 氰化钠 | CAS号89-98-5 邻氯苯甲醛 | CAS号313490-25-4 2-((叔丁氧基羰基)氨基)-... | CAS号111-85-3 氯辛烷 | CAS号29270-30-2 2-溴代-2-氯苯乙酸

合成工艺路线路线简述

合成目标产物 D-(+)-(2-Chlorophenyl)Glycine 主要起始原料 2,4-Imidazolidinedione, 5-(2-Chlorophenyl)-
89-98-5 = 86169-24-6
反应条件:1.1 Reagents: Potassium Hydroxide,Lithium Chloride,Ammonia Catalysts: Cinchonanium,9-Hydroxy-1-(Phenylmethyl)-,Chloride,(9S)- Solvents: Dichloromethane1.2 Solvents: Dichloromethane
标题:Synthesis Of Optically Active α-Amino Acids By Using Chiral Phase Transfer Catalyst
作者:Yang,Guang
参考文献:Huaxue Shiji 日期:2002 卷标:24(3) 页码:136-138]

141109-16-2 = 86169-24-6
反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Dichloromethane,Water; Rt -> 15 °C; Ph 6.9 - 7.2,15 °C
标题:Synthesis Of (R)-(-)-O-Chlorophenylglycine As Intermediate Of Clopidogrel Byproduct
参考文献:China]

742640-72-8 = 86169-24-6
反应条件:1.1 Catalysts: Nitrilase Solvents: 1-Octanol,Water; 48 H,10.5 Atm,25 °C
标题:High Yield Synthesis Of D-Phenylglycine And Its Derivatives By Nitrilase Mediated Dynamic Kinetic Resolution In Aqueous-1-Octanol Biphasic System
作者:Qiu,Jian; Et Al
参考文献:Tetrahedron Letters 日期:2014 卷标:55(8) 页码:1448-1451]

141109-13-9 = 86169-24-6
反应条件:1.1 Catalysts: Benzaldehyde Solvents: Methanol,Acetone; 1 H,Rt; 5 - 6 H,28 - 32 °C; 1 H,Cooled2.1 Reagents: Ammonium Hydroxide Solvents: Dichloromethane,Water; Rt -> 15 °C; Ph 6.9 - 7.2,15 °C
标题:Synthesis Of (R)-(-)-O-Chlorophenylglycine As Intermediate Of Clopidogrel Byproduct
参考文献:China

5-(2-氯苯基)-2,4-咪唑烷酮置于盐酸,Tris-Hcl Buffer,Sodium Nitrite体系中,化学反应 91.0H,反应生成 D-(+)-(2-氯苯)甘氨酸
参考文献:Production Of Ring-Substituted D-Phenylglycines By Microbial Or Enzymatic Hydrolysis/deracemisation Of The Corresponding Dl-Hydantoins
标题:Production Of Ring-Substituted D-Phenylglycines By Microbial Or Enzymatic Hydrolysis/deracemisation Of The Corresponding Dl-Hydantoins
摘要:A Series Of 17 Ring-Mono And-Disubstituted D-Phenylglycine Derivatives Was Prepared In High Enantiomeric Purity By Enzymatic Hydrolysis And Deracemisation Of The Corresponding Dl-Hydantoins,Using D-Hydantoinase Activities Of Microorganisms Or Purified Enzymes,Followed By Diazotation Of The Resulting N-Carbamyl D-Amino Acids. No Significant L-Hydantoinase Activity Was Found To Produce The Corresponding L-Enantiomers. (C) 1997,Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0957-4166(96)00488-0

海关参考信息

2902600000-乙苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:CN-114507650-A
优先权日:2022-01-28
标题 :Leucine dehydrogenase mutant and application thereof in synthesis of (S) -o-chlorophenylglycine

专利号:CN-114507650-B
优先权日:2022-01-28
标题 :Leucine dehydrogenase mutants and their application in the synthesis of (S)-o-chlorophenylglycine

专利号:CN-117778360-A
优先权日:2023-12-28
标题:Immobilized acylase and application thereof in synthesis of (S) -clopidogrel

专利号:CN-111607631-B
优先权日:2020-07-06
标题:A kind of (S)-o-chlorophenylglycine methyl ester enzymatic synthesis method