CAS: 81452-54-2; Methyl 3-Methylthiophene-2-Carboxylate

该化合物是一种有机化合物,其特点是其硫苯环结构,即五人组成的含有硫磺的芳香环,该化合物的特点是一个甲基组和一个碳箱状酯功能组,有助于其化学反应和有机合成的潜在应用,其典型的颜色是无色的黄色淡液,具有独特的芳香,表明其芳香性质;甲基硫磷组的存在增强了其反应性,使其在各种化学反应中有用,包括核糖类替代和作为合成更复杂的分子的建筑块.甲基三甲基硫苯基-2-碳箱状酸盐在有机溶剂中溶解,有助于其在各种化学过程中的使用.其特性使其在诸如药品,农业化学品和材料科学等领域具有兴趣,在其中可作为生物活性化合物或功能材料合成的中间体.应参考安全数据,用于处理和储存,如任何化学物质.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

diazomethane 3-methyl-2-thiophenecarboxylic acid 2-iodo-3-methylthiophene carbonic acid dimethyl estermethyl 4-bromo-3-methylthiophene-2-carboxylate methyl 4,5-dibromo-3-methylthiophene-2-carboxylate 3-methyl-4,5-dichlorothiophene-2-carboxylic acid methyl 3-(bromomethyl)thiophene-2-carboxylate

合成工艺路线路线简述

  • 61341-26-2 = 81452-54-2
    反应条件:1.1 Solvents: Methanol; 4 H,Rt -> 45 °C
    标题:Development Of Potential Manufacturing Routes For Substituted Thiophenes - Preparation Of Halogenated 2-Thiophenecarboxylic Acid Derivatives As Building Blocks For A New Family Of 2,6-Dihaloaryl 1,2,4-Triazole Insecticides
    作者:Hull,John W. Jr.; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2007 卷标:3]

    26137-08-6 + 80-48-8 = 81452-54-2
    反应条件:1.1 Reagents: Tetrabutylammonium Iodide,Zinc,Magnesium Chloride Catalysts: 4,4′-Dimethyl-2,2′-Bipyridine,Nickel Iodide (Nii2) Solvents: Dimethylacetamide; 12 H,Rt
    标题:Nickel-Catalyzed Methylation Of Aryl Halides/tosylates With Methyl Tosylate
    作者:Wang,Jiawang; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(73) 页码:10180-10183]

    181226-89-1 + 80-48-8 = 81452-54-2
    反应条件:1.1 Reagents: Tetrabutylammonium Iodide,Zinc,Magnesium Chloride Catalysts: Triphenylphosphine,Dichloro[1,2-Di(Methoxy-Ko)Ethane]Nickel Solvents: Dimethylacetamide; 12 H,25 °C
    标题:Nickel-Catalyzed Methylation Of Aryl Halides/tosylates With Methyl Tosylate
    作者:Wang,Jiawang; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(73) 页码:10180-10183]

    14282-76-9 = 81452-54-2
    反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran; < 40 °C; 60 Min,25 °C1.2 0.1 H,25 °C; 4 H,25 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Development Of Potential Manufacturing Routes For Substituted Thiophenes - Preparation Of Halogenated 2-Thiophenecarboxylic Acid Derivatives As Building Blocks For A New Family Of 2,6-Dihaloaryl 1,2,4-Triazole Insecticides
    作者:Hull,John W. Jr.; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2007 卷标:3]

    16494-40-9 = 81452-54-2
    反应条件:1.1 Reagents: Magnesium Solvents: Diethyl Ether
    标题:A New Synthesis Of Benzo[b]Thiophenes And Benzo[c]Thiophenes By Annulation Of Disubstituted Thiophenes
    作者:Terpstra,Jan W.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1986 卷标:51(2) 页码:230-8]

    13679-72-6 = 81452-54-2
    反应条件:1.1 Catalysts: Sodium Hypobromite2.1 Solvents: Methanol
    标题:Synthesis And Properties Of Methyl 3,4-Dihydro-4-Oxo-1H-2-Benzothiopyran-3-Carboxylate And Related Thiopyrano Compounds
    作者:Scrowston,Richard M.; Et Al
    参考文献:Journal Of The Chemical Society 日期:1976 卷标:(7) 页码:749-54]

    23806-24-8 = 81452-54-2
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide,1,2-Dichloroethane; 2 H,Reflux2.1 Solvents: Methanol; 4 H,Rt -> 45 °C
    标题:Development Of Potential Manufacturing Routes For Substituted Thiophenes - Preparation Of Halogenated 2-Thiophenecarboxylic Acid Derivatives As Building Blocks For A New Family Of 2,6-Dihaloaryl 1,2,4-Triazole Insecticides
    作者:Hull,John W. Jr.; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2007 卷标:3]

    59201-85-3 + 62353-77-9 + 51202-29-0 = 81452-54-2
    反应条件:1.1 Catalysts: Di-μ-Chlorobis(η3-2-Propenyl)Dipalladium Solvents: Dimethylformamide
    标题:A Convenient Synthesis Of Substituted Heteroaromatic Compounds Via The Palladium-Catalyzed Cross-Coupling Reaction Of Organosilicon Compounds
    作者:Hatanaka,Yasuo; Et Al
    参考文献:Heterocycles 日期:1990 卷标:30(1) 页码:303-6]

    5834-16-2 = 81452-54-2
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Perchloric Acid,Iron(3+) Salt,Hydrate Solvents: Methanol,Water; 4 H,0 °C; 1 H,0 °C; 0 °C -> Rt; 15 H,Rt
    标题:Iron-Catalyzed One-Pot Oxidative Esterification Of Aldehydes
    作者:Wu,Xiao-Feng; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2009 卷标:(8) 页码:1144-1147]

    = 81452-54-2
    反应条件:1.1 Reagents: Oxygen Catalysts: Chloro(Triphenylphosphine)Gold,[1,1,1-Trifluoro-N-[(Trifluoromethyl)Sulfonyl-Ko]Methanesulfonamidato-Ko]Silver Solvents: Dichloromethane; 10 Min,1 Atm,Rt1.2 Reagents: Methanol,Oxygen Solvents: Dichloromethane; 24 H,1 Atm,25 °C
    标题:Gold-Catalyzed Oxidative Cleavage Of Aryl-Substituted Alkynyl Ethers Using Molecular Oxygen. Simultaneous Degradation Of C-H And Single And Triple Carbon-Carbon Bonds Under Ambient Conditions
    作者:Das,Arindam; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2009 卷标:(27) 页码:4046-4048]

    5118-06-9 = 81452-54-2
    反应条件:1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 15 Min,0 °C; 0 °C -> Rt; 2 H,Rt2.1 Reagents: Tetrabutylammonium Iodide,Zinc,Magnesium Chloride Catalysts: Triphenylphosphine,Dichloro[1,2-Di(Methoxy-Ko)Ethane]Nickel Solvents: Dimethylacetamide; 12 H,25 °C
    标题:Nickel-Catalyzed Methylation Of Aryl Halides/tosylates With Methyl Tosylate
    作者:Wang,Jiawang; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(73) 页码:10180-10183]

    = 81452-54-2
    反应条件:1.1 Reagents: Acetic Anhydride,N-Bromosuccinimide Solvents: Acetic Acid; Rt -> 44 °C; 20 Min,Rt1.2 Reagents: Sodium Bisulfite Solvents: Water; 0 °C2.1 Reagents: Magnesium Solvents: Tetrahydrofuran; < 40 °C; 60 Min,25 °C2.2 0.1 H,25 °C; 4 H,25 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Development Of Potential Manufacturing Routes For Substituted Thiophenes - Preparation Of Halogenated 2-Thiophenecarboxylic Acid Derivatives As Building Blocks For A New Family Of 2,6-Dihaloaryl 1,2,4-Triazole Insecticides
    作者:Hull,John W. Jr.; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2007 卷标:3]

    23806-24-8 + 14282-78-1 = 81452-54-2 + 28686-90-0
    反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Methanol
    标题:Synthesis Of N-(Methoxycarbonylthienylmethyl)Thioureas And Evaluation Of Their Interaction With Inducible And Neuronal Nitric Oxide Synthase
    作者:Suaifan,Ghadeer A. R. Y.; Et Al
    参考文献:Molecules 日期:2010 卷标:15 页码:3121-3134]

    = 81452-54-2 + 28686-90-0
    反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; 0 °C; 3 H,0 °C1.2 Solvents: Diethyl Ether; 0 °C; 16 H,0 °C1.3 Reagents: Water; Cooled
    标题:Synthesis Of N-(Methoxycarbonylthienylmethyl)Thioureas And Evaluation Of Their Interaction With Inducible And Neuronal Nitric Oxide Synthase
    作者:Suaifan,Ghadeer A. R. Y.; Et Al
    参考文献:Molecules 日期:2010 卷标:15 页码:3121-3134
3-甲基噻吩-2-羧酸置于氯化亚砜体系中,化学反应 1.25H,反应生成 3-甲基噻吩-2-甲酸甲酯
参考文献:Flavone-8-Acetic Acid (Faa) 新衍生物的合成和抗肿瘤活性.第 31 部分):2-杂芳基衍生物
标题:Flavone-8-Acetic Acid (Faa) 新衍生物的合成和抗肿瘤活性.第 31 部分):2-杂芳基衍生物
摘要:已经制备了一系列 14 种黄酮-8-乙酸 (Faa) 衍生物,其中杂环取代基取代了 2-苯基,并在体外针对一组人和鼠肿瘤细胞系评估了它们的抗肿瘤活性和在体内针对 Mac 15A.一些化合物,特别是 2C,D 和 S,显示出显着的体内活性,这些需要进一步研究以评估其发展潜力.
DOI:10.1002/(Sici)1521-4184(199812)331:12<405::Aid-Ardp405>3.0.Co;2-2

海关参考信息

专利信息


专利号:US-2024199637-A1
优先权日:2021-04-21
标题 :Improved process for the preparation of 7-(morpholinyl)-2-(n-piperazinyl)methylthieno[2, 3-c]pyridine derivatives
发明人：KOMPELLA AMALA; VAGICHERLA KAMESWARA RAO; LANKI REDDY TIRUMALA REDDY; PESARU NARMADA; MUDDASANI PULLA REDDY; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:The present invention describes an improved second generation process for the synthesis of NRC-1111 (1,5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-7-(4-morpholinyl)thieno[2,3-c] pyridine-5-yl]-2-pyrimidinamine) dimethane sulfonate and NRC-1109 (II, 5-[3-methyl-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-7-morpholino-thieno[2,3-c]pyridin-5-yl]pyrimidin-2-amine) dimethane sulfonate. This process is cost effective, high yielding and industrially feasible process for the synthesis of compounds of formulae I and II with high purity. Formula (I) Formula (I): Râ•?H for NRC-1111 and Formula (II): Râ•?CH3 for NRC-1109 NRC-1111 and NRC-1109 are potential anti-cancer agents.

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.

专利号:WO-2010065383-A1
优先权日:2008-11-25
标 题 :Calcilytic compounds
发明人：CASILLAS LINDA N; CHARNLEY ADAM KENNETH; HARRIS PHILIP ANTHONY; JEONG JAE U; MARQUIS ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT
权利人:GLAXOSMITHKLINE LLC; CASILLAS LINDA N; CHARNLEY ADAM KENNETH; HARRIS PHILIP ANTHONY; JEONG JAE U; MARQUIS ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:CN-105111197-B
优先权日:2015-08-26
标 题:Synthesis method of raltitrexed

其他信息查阅

南京新斯特生物科技有限公司
⚠️ 未注册 · 未认证企业
⚠️ 该商家尚未完成注册及企业认证，请用户仔细辨别，谨慎交易。
数据来源于公开网络搜索，平台未作核实，请自行辨别。
🏢敬请 企业认领
🏬开设公司展台
📢获取免费会员权益
🎖️点亮专属注册企业标签
📇展现公司完整信息 样本查看立即注册认领 →
网址: http://www.nstbio.com
企业联系电话：025-85331029,18915981017👤
📞南京新斯特生物科技有限公司 ⚠️参考联系方式
联系人：杨女士
电话：025-85331029,18915981017
手机：18915981017
传真：025-85331829
邮箱：sales@nstbio.com
通信地址: 江苏省南京市栖霞区纬地路9号江苏省生命科技创新园F6栋10楼
邮编: 210010
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→

地址:江苏省南京市栖霞区纬地路9号江苏省生命科技创新园F6栋10楼
⚠️ 未注册 · 未认证企业
注册入口 备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。
第 1 / 1 页

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 186.
摘要:Jha, N.; Kapur, M., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 110.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知