CAS: 78008-15-8; 2,2,2-Trifluoro-N-(3-Hydroxypropyl)Acetamide

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📜三氟乙酰氯,3-氨基-1-丙醇置于三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 3-(四氟乙酰氨)-1-丙醇
参考文献:通过(不对称)p(iii)/ P(v)氧化还原环的膦催化合成手性n-杂环
标题:通过(不对称)p(iii)/ P(v)氧化还原环的膦催化合成手性n-杂环
摘要:已经开发了膦催化的串联迈克尔加成/分子内wittig反应用于合成手性2,5-二氢-1 H-吡咯和四氢吡啶衍生物.由于苯基硅烷原位还原了氧化膦,这些工艺在膦中变得具有催化作用.此外,使用对映纯手性膦进行催化和不对称p(iii)/ P(v)过程.
DOI:10.1002/ejoc.202100404

专利信息

专利号:US-9422232-B2
优先权日:2009-07-09
标题:Reductive release probes containing a chemoselectively cleavable α-azidoether linker and methods of use thereof
发明人：FRANZINI RAPHAEL M; KOOL ERIC TODD
权利人:FRANZINI RAPHAEL M; KOOL ERIC TODD; UNIV LELAND STANFORD JUNIOR
摘要:Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.