CAS: 72-80-0; 5,7-Dichloro-2-Methylquinolin-8-Ol

该化合物是一种卤化氢氧基素衍生物,具有显著的抗微生物和抗风素特性,通常用于治疗皮肤感染,包括细菌和真菌造成的皮肤感染的热剂制剂;该复合物展示了针对抗淋病细菌和某些酵母的广泛光谱活动,使其有效地管理皮肤状况,如乳胶,皮炎和轻伤;其行动机制包括干扰微生物细胞膜和抑制必要的酶性过程;氯因其稳定性,系统吸收率低和刺激潜力最小而受到重视,使其适合长期用于抗菌和防腐剂用途;其功效和安全性特征支持将其纳入药用奶油,药膏和粉.

结构式图片

相似化合物

773-76-2 876-86-8 37026-23-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2-methyl-8-quinolinol 5,7-dichloro-8-hydroxyquinoline 1-oxide methylmagnesium chloride dichlorohydantoin 8-acetoxy-5,7-dichloro-2-[2-(3,4,5-trimethoxyphenyl)vinyl]quinoline 5,7-dichloro-2-[2-(3,5-dihydroxyphenyl)vinyl]quinolin-8-ol 5,7-dichloro-2-[2-(4-hydroxyphenyl)vinyl]quinolin-8-ol 5,7-dichloro-2-[2-(2-hydroxyphenyl)vinyl]quinolin-8-ol

合成工艺路线路线简述

    8-羟基喹哪啶置于盐酸,氯体系中,用 水 作为反应溶剂,以98.9%的收率获得产物5,7-二氯-8-羟基喹哪啶
    参考文献:氯喹那多的制备方法
    标题:氯喹那多的制备方法
    摘要:本发明属于医药技术领域,具体涉及一种氯喹那多的制备方法.氯喹那多盐酸盐加水溶清,在避光和氮气保护条件下,加入缓冲液,用碱调ph值,过滤,精制得到氯喹那多.本发明操作简便,适用于工业化生产,制得的氯喹那多纯度较高,能达到99.99%以上,产品的稳定性高.

    海关参考信息

    专利信息


    专利号:US-7105617-B2
    优先权日:2003-02-06
    标题:Metal 8-hydroxyquinoline-functionalized polymers and related materials and methods of making and using the same
    发明人:WECK MARCUS; MEYERS AMY
    权利人:GEORGIA TECH RES INST
    摘要:This invention relates to the synthesis of Mq n -containing monomeric compounds, comprising a polymerizable moiety, an Mq n -moiety, and an optional chemical spacer therebetween, wherein q, in each instance, comprises an 8-hydroxyquinoline residue, M is a metal such as Mg, Zn, Al, Ga, or In, and n is 2 or 3 as the valence of the metal requires. For example, the polymerization of Znq 2 - or Alq 3 -containing monomers, in the presence or absence of a co-monomer, provided a Znq 2 - or Alq 3 -containing polymer, which retained the optical properties of Znq 2 or Alq 3 in solution, respectively. The Mq n -containing polymers may be used in, among other things, the fabrication of light-emitting diodes (LEDs).

    专利号:US-7601848-B2
    优先权日:2001-12-22
    标 题:Multifunctional reagent for the synthesis of thiol modified oligomers
    发明人:HARTWICH GERHARD; FRISCHMANN PETER; FERRER ELISENDA
    权利人:FIDICULA GMBH
    摘要:The invention relates to compounds of formula (I), wherein Z represents a hydrocarbon with 2 to 28 C atoms, wherein Z can also comprise elements N, O, P, S, Si and halogen as heteroatoms, R 1 and R 2 are identical or different sulfur protecting groups, wherein both S atoms can also form a disulfide bridge and in said case R 1 and R 2 are not present; protecting group Y 1 represents protecting group NH, protecting group NR 4 , protecting group O, CONH protecting group, protecting group OOC, protecting group S—S, —CH(protecting group O) 2 or —CR 5 (protecting group O) 2 or protecting group S; Y 2 represents —OH, —NH 2 , —NHR 3 , —NR 3 R 4 , —COOH, —COCI, —COOCO—R 6 , —CONH 2 , —CONHR 3 , —COOR 3 , —SO 3 H, —SO 3C I, —SH, —S—SR 3 , —CHO, —COR 3 , —C 2 H 3 O, halogen, —N 3 , —NH—NH 2 , —NCO, —NCS, wherein R 3 represents alkyl, heteroalkyl, aryl, cycloalkyl or a protecting group, wherein R 3 can be identical or different in groups Y 1 and Y 2 , R 4 is s protecting group, wherein R 4 can be identical or different in groups Y 1 and Y 2 , and wherein R 4 and R 3 can be identical or different, R 5 represents alkyl, aryl or cycloalkyl, wherein R 5 can be identical or different in groups Y 1 and Y 2 and R 6 represents alkyl, heteroalkyl, aryl or cycloalkyl, wherein R 6 can be identical or different in groups Y 1 and Y 2 , wherein Y 2 can also represent a group of formula (II) or formula (III), wherein X 1 represents halogen or a substituted amine, X 2 represents an alkyl, alkoxy, aryloxy radical or a cyano derivative of an alkyl, alkoxy, aryloxy radical, X 3 represents halogen, an amino function or oxygen and X 4 represents an alkyl, alkoxy, aryloxy radical or X 4 equals H if X 3 =oxygen.

    专利号:EP-1626952-A2
    优先权日:2001-12-22
    标 题:Multifunctional reagent for the synthesis of thiol modified oligomers

    专利号:US-4093812-A
    优先权日:1975-03-25
    标 题:(Nitrofuryl)pyrazoles, their synthesis and use, and compositions containing them
    发明人:RAINER GEORG
    权利人:BYK GULDEN LOMBERG CHEM FAB
    摘要:3-(5-Nitro-2-furyl)pyrazoles unsubstituted in the 5-position and 5-(5-nitro-2-furyl)pyrazoles unsubstituted in the 3-position are antimicrobials and disinfectants. The compounds are structurally represented by one of the formulae: ##STR1## wherein A is --CHO, --CN, --COOH, a protected or derived aldehyde group or a protected or derived carboxylic acid group; n B is 5-nitro-2-furyl; n R 1 is --H, substituted or unsubstituted hydrocarbyl (saturated or unsaturated; acyclic, alicyclic or aromatic; or araliphatic); substituted or unsubstituted (cycloaliphatic or aromatic) heterocyclic or acyl (carboxylic or carbonic acid); n R 2 is --H; and n n is a positive whole number of at most 2.

    专利号:US-2005153291-A1
    优先权日:2001-12-22
    标 题:Multifunctional reagent for the synthesis of thiol modified oligomers

    专利号:WO-03055852-A2
    优先权日:2001-12-22
    标 题:Multifunctional reagent for the synthesis of thiol modified oligomers
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    主要参考文献


    1: Bidossi A, Bottagisio M, De Grandi R, Drago L, De Vecchi E. Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm- related antimicrobial cross-resistance. Infect Drug Resist. 2019 Jul 19;12:2177-2189. doi: 10.2147/IDR.S211007.
    2: Veraldi S, Schianchi R, Esposito L, Pontini P, Nazzaro G. Treatment of postscabies prurigo with diflucortolone and chlorquinaldol in a group of African refugees. Trop Doct. 2019 Oct;49(4):268-270. doi: 10.1177/0049475519855577. Epub 2019 Jun 18.
    159:104955. doi: 10.1016/j.phrs.2020.104955. Epub 2020 May 30. 29(2):115-118. doi: 10.29271/jcpsp.2019.02.115.

    合成参考文献


    摘要:Handbook of Analytical Toxicology, Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969, -(33), 1969
    参考文献:10.1016/0731-7085(96)01791-8
    摘要:Pe´rez-Ruiz T, Marti´nez-Lozano C, Toma´s V, Carpena J. Fluorimetric determination of chloroxine using manual and flow-injection methods. Journal of Pharmaceutical and Biomedical Analysis. 1996 Aug;14(11):1505–11. doi: 10.1016/0731-7085(96)01791-8.
    参考文献:10.2165/00128071-200203010-00007|10.2165/00128071-200203020-00006|10.2165/00128071-200203030-00008|10.2165/00128071-200203040-00007|10.2165/00128071-200203050-00008|10.2165/00128071-200203060-00007|10.2165/00128071-200203070-00009|10.2165/00128071-200203080-00010|10.2165/00128071-200203090-00006
    摘要:Cutaneous drug reaction case reports: from the world literature. Am J Clin Dermatol. 2002;3(9):637–43. doi: 10.2165/00128071-200203090-00006.
    参考文献:10.3181/00379727-99-24308
    摘要:SCHNEIERSON SS, AMSTERDAM D, LITTMAN ML. Inactivation of amphotericin B, chlorquinaldol, gentian violet and nystatin by bile salts. Proc Soc Exp Biol Med. 1958 Oct;99(1):241–4. doi: 10.3181/00379727-99-24308.
    摘要:FULLER H. [Clinical experience with sterosan]. Z Haut Geschlechtskr. 1954 Mar 15;16(6):177–9.
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