CAS: 69659-80-9; Sodium 1,6,6-Trimethyl-10,11-Dioxo-6,7,8,9,10,11-Hexahydrophenanthro[1,2-B]Furan-2-Sulfonate
该化合物是Tanshineone IIA(从Salvia miltiorrhiza (Danshen) 提取的生物活性化合物)的一种可溶水衍生物,这种改良形式增强了生物利用率和稳定性,使之适合于研究和药物应用,具有显著的药理特性,包括抗炎,抗氧化剂和心血管保护作用,特别是在心血管和脑血管疾病研究中.其磺酸钠组改善了水系统溶性,促进了体外和体外实验.该化合物广泛用于针对异化学-再生伤害,甲状腺硬化症和内阴性功能障碍的机械学研究.高纯度等级确保了临床前研究的可复制性.
- 英文名称Sodium 1,6,6-Trimethyl-10,11-Dioxo-6,7,8,9,10,11-Hexahydrophenanthro[1,2-B]Furan-2-Sulfonate
- 中文名称丹参酮IIA-磺酸钠
- IUPAC名称sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate
- 其它别名1,6,6-Trimethyl-10,11-Dioxo-8,9-Dihydro-7H-Naphtho[1,2-G][1]Benzofuran-2-Sul
- CAS编号69659-80-9
- MFCD编号:MFCD09028094
- FDA UNII编号:IVJ88KQ4XN
- 分子式:C19H17NaO6S分子量:396.4
- 产品CID: 2508118
- 产品分类化学试剂 → 有机试剂 → 磺酸盐/亚磺酸盐
物理性质
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专利信息
专利号:US-12173333-B2
优先权日:2017-08-07
标 题:Variants of family a DNA polymerase and uses thereof
发明人：YBERT THOMAS; CHAMPION ELISE; VIVAR OMAR; SAID AHMED
权利人:DNA SCRIPT
摘要:The present invention relates to variant of Family A polymerases able to synthesize a nucleic acid fragment without template and to incorporate a reversible modified terminator nucleotide during the nucleic acid fragment synthesis. The present invention further relates to uses thereof for enzymatic synthesis of nucleic acid molecules.
专利号:CN-104341482-A
优先权日:2013-08-09
标 题 :Synthesis of a Heterocyclic Sulfonic Acid Derivative and Its Application in Drug Therapy
专利号:CN-104341482-B
优先权日:2013-08-09
标题 :Synthesis of a Heterocyclic Sulfonic Acid Derivative and Its Application in Drug Therapy
专利号:CN-115197851-A
优先权日:2022-05-30
标题:Penicillium difficile and its use in regulating the synthesis of tanshinones in the roots of Salvia miltiorrhiza
专利号:CN-115197851-B
优先权日:2022-05-30
标题 :Penicillium rugosa and its use in regulating the synthesis of tanshinone components in the root of Danshen
专利号:CN-104524579-A
优先权日:2014-11-26
标 题 :Denovo synthesis inhibitor with NQO1 targeted drug as NAD+ and application of denovo synthesis inhibitor to tumor resistance
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主要参考文献
1: Tang J, Zhu C, Li ZH, Liu XY, Sun SK, Zhang T, Luo ZJ, Zhang H, Li WY. Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain. J Neuroinflammation. 2015 Mar 25;12:57. doi: 10.1186/s12974-015-0279-7.
2: Kaiser M, Sobottka H, Fischer W, Schaefer M, Nörenberg W. Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7. J Pharmacol Exp Ther. 2014 Sep;350(3):531-42. doi: 10.1124/jpet.114.214569. Epub 2014 Jun 26.
合成参考文献
参考文献:10.1021/np300628a
摘要:Hatfield MJ, Tsurkan LG, Hyatt JL, Edwards CC, Lemoff A, Jeffries C, Yan B, Potter PM. Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen"). J Nat Prod. 2013 Jan 25;76(1):36–44.
摘要:https://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b01709
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