CAS: 6325-91-3; 2-Mercapto-5-Nitrobenzimidazole

相似化合物

583-39-1 27231-36-3 25369-78-2

1H-苯并咪唑-2-硫醇置于硫酸,硝酸体系中,用 水 作为反应溶剂,化学反应生成 2-巯基-5-硝基苯并咪唑
参考文献:作为潜在抗糖尿病药物的薏苡酚衍生物的设计,合成和生物学评价
标题:作为潜在抗糖尿病药物的薏苡酚衍生物的设计,合成和生物学评价
摘要:天然产物具有巨大的结构修饰潜力,可以达到预期的生物学效应.此外,与合成药物相比,这些被认为更安全,更便宜且更容易获得.天然化合物薏苡仁是一种有效的胰岛素促分泌剂,从scoparia Dulcis和coix Lacryma Jobi的植物部分中提取. 在目前的研究工作中,我们合成了基于薏苡酚的衍生物,这些衍生物有可能成为成功的抗糖尿病药物.我们之前的工作解释了基于天然产物薏苡醇的独家分子对接研究,这导致目前选择了十二种分子,包括 2-苯并恶唑啉酮,2-苯并咪唑啉酮和苯并咪唑-2-硫酮,它们对 Atp 敏感性钾通道具有非常好的结合亲和力. 使用大鼠胰岛素 Elisa 测定筛选所有合成分子用于体外研究.其中,化合物14A和34被确定为最有效的分子,胰岛素分泌百分比浓度分别为 162.43 和 227.16 µu/ml,据报道高于标准药物格列本脲.使用链脲佐菌素诱导的ii 型糖尿病大鼠模型检查体内抗
DOI:10.1016/j.Molstruc.2022.134861

专利信息

专利号:US-7919630-B2
优先权日:2005-09-30
标题 :Synthesis of imidazole 2-thiones via thiohydantoins
发明人：GARST MICHAEL E; DOLBY LLOYD J; ESFANDIARI SHERVIN; AVEY JR ALFRED A; MACKENZIE VIVIAN ROSE; MUCHMORE CHARLES DAVID
权利人:ALLERGAN INC
摘要:The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.

专利号:US-10557210-B2
优先权日:2014-02-24
标题 :Direct electrochemical synthesis of doped conductive polymers on metal alloys
发明人：KINLEN PATRICK JOHN; LAWLESS LAWRENCE MICHAEL
权利人:BOEING CO
摘要:This disclosure relates generally to the discovery of improved methods of reducing corrosion on metals and metal alloys without using hexavalent chromium reagents. More particularly, the disclosure relates to preparing corrosion resistant metals using doped conducting polymers such as polyaniline (PANI) on metal alloys such as aluminum alloys.

专利号:JP-6856608-B2
优先权日:2014-02-24
标 题:Direct electrochemical synthesis of dope conductive polymer on metal alloy

专利号:US-4246173-A
优先权日:1978-04-24
标题 :Process for preparing tetraselenofulvalenes, and conductive salts obtained therefrom
发明人：COWAN DWAINE O; BLOCH AARON N; BECHGAARD KLAUS
权利人:UNIV JOHNS HOPKINS
摘要:A multistep process for preparing tetraselenofulvalenes involving the synthesis of 1,3-diselenole-2-selones and -2-thiones from diselenocarbamates and α-haloketones followed by coupling of the selone or thione using a dechalkogenizing reagent. New highly conductive salts obtained by coupling certain tetraselenofulvalenes with acceptor compounds are also disclosed.

专利号:US-2007203344-A1
优先权日:2005-09-30
标 题 :Synthesis of imidazole 2-thiones via thiohydantoins

专利号:CA-2878540-C
优先权日:2014-02-24
标题:Direct electrochemical synthesis of doped conductive polymers on metal alloys