CAS: 617-73-2; 2-Hydroxy-N-Octanoic Acid

相似化合物

1117-86-8 764-67-0 629-22-1

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CAS号773837-37-9 sodium cyanide | CAS号111-71-7 正庚醛 | CAS号2623-82-7 2-溴正辛酸 | CAS号592-41-6 1-己烯 | CAS号70267-27-5 (S)-2-hydroxy°C... | CAS号127-09-3 乙酸钠 | CAS号13495-04-0 HEPTALDEHYDE SO... | CAS号328-51-8 2-羰基羊脂酸 | CAS号5445-22-7 2-溴辛酸甲酯 | CAS号111-71-7 正庚醛 | CAS号64-18-6 甲酸 | CAS号111-14-8 庚酸 | CAS号7367-81-9 反-2-辛烯酸甲酯 | CAS号35234-16-3 methyl (E)-3-°C... | CAS号124-38-9 二氧化碳 | CAS号144-62-7 草酸

1,2-辛二醇置于sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,Potassium Bromide体系中,用 丙酮 作为反应溶剂,化学反应 1.5H,反应生成 2-羟基辛酸
参考文献:单取代乙二醇的化学选择性氧化:光学活性α-羟基酸的便捷合成†
标题:单取代乙二醇的化学选择性氧化:光学活性α-羟基酸的便捷合成†
摘要:描述了一种使用tempo-Naocl试剂系统通过单取代乙二醇的化学选择性氧化合成旋光性α-羟基酸的温和有效方法.从我们的研究中可以明显看出,溶剂,Ph和反应温度对于这种氧化的成功至关重要.已经用带有各种官能团的各种脂族,芳族和碳水化合物底物证明了该方法的多功能性.
DOI:10.1039/c4Ob00601A

专利信息

专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:EP-0870837-B1
优先权日:1989-07-10
标题 :A recombinant plant or plant cell capable of producing polyhydroxybutyrate or another polyhydroxyalkanoate
发明人：PEOPLES OLIVER P; SINSKEY ANTHONY J
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method for controlling and modifying biopolymer synthesis by manipulation of the genetics and enzymology of synthesis of polyhydroxybutyrate (PHB) and polyhydroxyalkanoate (PHA) polyesters at the molecular level in procaryotic and eukaryotic cells, especially plants. Examples demonstrate the isolation, characterization, and expression of the genes involved in the production of PHB and PHA polymers. Genes encoding the enzymes in the PHB and PHA synthetic pathway (beta-ketothiolase, acetoacetyl-CoA reductase and PHB polymerase or PHA polymerase) from Zoogloea ramigera strain I-16-M, Alcaligenes eutrophus, Nocardia salmonicolur, and Pseudomonas oleovarans were identified or isolated and expressed in a non-PHB producing organism, E. coli. Specific modification to the polymers include variation in the chain length of the polymers and incorporation of different monomers into the polymers to produce co-polymers with different physical properties.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9550719-B2
优先权日:2013-05-09
标题 :Process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds
发明人：MURUGAN MUTHUKRISHNAN; MOHAMMAD MUJAHID
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein R 1 represents H or (C 1 -C 5 ) alkyl groups and R 2 represents (C 1 -C 5 ) alkyl groups.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.