专利号:US-10253153-B2 优先权日:2015-04-24 标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support 发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI 权利人:NITTO DENKO CORP 摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.
专利号:US-8445713-B2 优先权日:2007-10-22 标 题 :Catalyst for the synthesis of organic carbonates, process for preparing the same and application thereof 发明人:WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; WANG XINKUI; WANG JUNWEI; KANG MAOQING 权利人:WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; WANG XINKUI; WANG JUNWEI; KANG MAOQING; BAYER MATERIALSCIENCE AG 摘要:The present invention relates to a catalyst for the synthesis of organic carbonates, the preparation of the catalyst and the application of this catalyst in the synthesis of organic carbonates from reacting urea and hydroxyl group containing compounds. The catalyst provided in this invention is a calcinate of hydrous salt containing rare earth element at a moderate calcining temperature.
专利号:US-10487048-B2 优先权日:2015-03-13 标 题:Configuration and its use in process for synthesis of alkyl carbamates from alkyl alcohol and urea in a tubular reactor 发明人:RANADE VIVEK VINAYAK; KELKAR ASHUTOSH ANANT; RANE VILAS HARI; KINAGE ANIL KISAN; MOTE DHANANJAY RAVINDRA; SHINGOTE SAVITA KIRAN; ROY LALITA SANJIB 权利人:COUNCIL SCIENT IND RES 摘要:The present invention discloses an improved catalyst free process for synthesis of alkyl carbamates in an integrated system comprising a tubular reactor and a striper. The process comprises reacting urea and an alcohol in said tubular reactor under autogeneous pressure; wherein said process provides >90% selectivity towards alkyl carbamate. The mixture of urea and alcohol is N fed to the tubular reactor at a particular feed rate. The tubular reactor is heated externally under autogeneous pressure to carry out a synthesis reaction producing alkyl carbamate and ammonia. The ammonia is removed from the tubular reactor by the striper. The tubular reactor and the stripper are arranged in series to reduce the equilibrium limitations of the reaction and drive the reaction in forward direction.
专利号:US-2023183223-A1 优先权日:2020-05-14 标题:Process for the synthesis of n-butyloxycarbonyl-3-(4-imidazol-1- ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide 发明人:CERNAKS DMITRIJS; DEGE ELIZA 权利人:VICORE PHARMA AB 摘要:There is provided a new process for the synthesis of compounds of formula I, which are useful as angiotensin (Ang II) type 2 receptor agonists: by reacting a compound of formula II, with an excess of a compound of formula III, wherein W, Z and X have meanings given in the description; followed by reaction of the intermediate so formed with a suitable source of the counter-ion, W.
专利号:US-10336681-B2 优先权日:2015-03-23 标 题:Process for the synthesis of dialkyl carbonates 发明人:RANADE VIVEK VINAYAK; KELKAR ASHUTOSH ANANT; RANE VILAS HARI; KINAGE ANIL KISAN; SHINGOTE SAVITA KIRAN; ROY LALITA SANJIB 权利人:COUNCIL SCIENT IND RES 摘要:The patent discloses a process for the synthesis of dialkyl carbonates catalyzed by a catalyst composition AB oxides, wherein A and B are rare earth metals or A and B are combination of rare earth and transition metals with ratios ranging from 0.5:10 to 10:0.5.
专利号:US-8338634-B2 优先权日:2008-02-26 标 题:Catalyst for the synthesis of alkyl carbamates, the method for preparing the same and the use thereof 发明人:DENG YOUQUAN; MA YUBO; WANG LIGUO; GUO XIAOGUANG; ZHANG SHIGUO; HE YUDE; WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING 权利人:DENG YOUQUAN; MA YUBO; WANG LIGUO; GUO XIAOGUANG; ZHANG SHIGUO; HE YUDE; WERSHOFEN STEFAN; KLEIN STEPHAN; ZHOU ZHIPING; BAYER MATERIALSCIENCE AG 摘要:The present invention pertains to a catalyst for the synthesis of organic alkyl carbamates, the method for preparing the same and the use thereof. The catalyst comprises a catalytically active component and a catalyst support, and the catalytically active component being carried by the catalyst support, wherein the catalytically active component comprises a transition metal oxide, and the general formula of the transition metal oxide is EOx, wherein E is selected from transition metal element and x is in the range of 0.5-4.
[参考文献]: Yong Gun Kim, Et Al. Effect Of Citrulline, Urea, Ethanol, And Urease On The Formation Of Ethyl Carbamate In Soybean Paste Model System. Food Chem. 2015 Dec 15:189:74-9.
合成参考文献
摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 141. 摘要:Beccalli, E. M.; Bonetti, A.; Mazza, A., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 1, 436. 摘要:Mace Weldy, N.; Blakey, S. B., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 250. 摘要:Australian Journal of Experimental Biology and Medical Science., 45(507), 1967 [] 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)