CAS: 53439-96-6; Isopropyl (S)-2-Hydroxy-2-Phenylacetate

英文名称Isopropyl (S)-2-Hydroxy-2-Phenylacetate
中文名称普瑞巴林杂质D
CAS编号53439-96-6
分子式:C11H14O3分子量:194.23
产品CID: 2533418
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: SCJJMBMUZTUIJU-JQHDBZEONA-N
InChI=1/C11H14O3/c1-8(2)14-11(13)10(12)9-6-4-3-5-7-9/h3-8,10,12H,1-2H3/t10-/s3
计算化学: 氢键受体数3.0氢键供体数1可旋转键数3

相似化合物

4118-51-8 20698-91-3 21210-43-5

MSDS等安全信息

上下游产品

isopropyl benzoylformate (S)-Mandelic acid isopropyl alcohol triphenylbismuthane (2-isopropoxy-2-oxo-(S)-1-phenylethyl) α-bromopropanoate (2-isopropoxy-2-oxo-(S)-1-phenylethyl) α-bromophenylacetate

合成工艺路线路线简述

合成目标产物 Pregabalin Impurity D 主要起始原料 Isopropylphenylglyoxylate
31197-66-7 = 53439-96-6 + 89015-27-0
反应条件:1.1 Catalysts: Dibutylmagnesium,Dinaphtho[2,1-D:1′,2′-F][1,3,2]Dioxaphosphepin,4-Hydroxy-2,6-Di-9-Phenanthrenyl... Solvents: Mesitylene,Toluene; 10 Min,Rt1.2 Reagents: Catecholborane; 24 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water; Rt
标题:Enantio- And Chemoselective Bronsted-Acid/mg(Nbu)2 Catalysed Reduction Of α-Keto Esters With Catecholborane
作者:Enders,Dieter; Stoeckel,Bianca A.; Rembiak,Andreas
参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(34) 页码:4489-4491]

6818-08-2 = 53439-96-6 + 89015-27-0
反应条件:1.1 Solvents: Diethyl Ether,Water; 17 H,Ph 8,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4
标题:Synthesis Of Chiral α-Aryl-α-Hydroxyacetic Acids: Substituent Effects In Pig Liver Acetone Powder (Plap) Induced Enantioselective Hydrolysis
作者:Basavaiah,Deevi; Krishna,Peddinti Rama
参考文献:Tetrahedron 日期:1995 卷标:51(8) 页码:2403-16

📜3'-甲基苯乙酮置于selenium(Iv) Oxide,C49H76N4O4,碘,Aluminum Tri-Tert-Butoxide,Potassium Carbonate,Yttrium(Iii) Trifluoromethanesulfonate体系中,用 1,4-二氧六环,氯仿,水,异丙醇,甲苯作为反应溶剂,化学反应 120.0H,反应生成普瑞巴林杂质80
参考文献:手性n,N'-二氧化物/ Y(otf)3配合物诱导的乙二酸酯的催化不对称meerwein-Ponndorf-Verley还原.
标题:手性n,N'-二氧化物/ Y(otf)3配合物诱导的乙二酸酯的催化不对称meerwein-Ponndorf-Verley还原.
摘要:乙醛酸酯的不对称meerwein-Ponndorf-Verley(mpv)还原是首次通过n,N'-Dioxide / Y(otf)3配合物与烷氧基铝和分子筛(mss)作为关键添加剂实现的.获得了多种旋光性α-羟基酯,具有优异的结果.根据实验提出了可能的反应机理.
DOI:10.1039/c7Cc00273D