CAS: 481075-58-5; 2-Bromo-1-Iodo-4-(Trifluoromethyl)Benzene

上下游产品

3-bromo-1-trifluoromethylbenzene 4-amino-3-bromobenzotrifluoride potassium iodide 1-bromo-3-iodo-5-(trifluoromethyl)benzene 1-bromo-5-trifluoromethyl-2-(prop-1-ynyl)benzene

4-氨基-3-溴三氟甲苯置于盐酸,Sodium Nitrite,Potassium Iodide体系中,用 水 作为反应溶剂,化学反应生成 3-溴-4-碘三氟甲苯
参考文献:Sulfide‐directed Ir‐catalyzed Vinylic Sp2 And Benzylic Sp3 C−h Activation For The Construction Of Sulfur‐containing Medium‐ring System
标题:Sulfide‐directed Ir‐catalyzed Vinylic Sp2 And Benzylic Sp3 C−h Activation For The Construction Of Sulfur‐containing Medium‐ring System
摘要:摘要 本研究揭示了由硫引导的乙烯基 Sp2 和苄基 Sp3 C-H 活化引发的铱催化转化,从而构建出含硫的七元和八元体系.烯丙基 2-炔基苯基硫化物转化成二氢苯并噻吩的收率为 30-95%,2-炔基芳基 2-甲苯硫化物转化成二苯并[b,F]噻吩的收率为 57-95%,同时还发生了双键异构化反应.在这两个反应中,Ir 催化剂和硫化物分子的结合是实现快速环化的关键.
DOI:10.1002/chem.202300255

专利信息

专利号:US-9925177-B2
优先权日:2015-01-22
标题:4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

专利号:US-11123337-B2
优先权日:2015-01-22
标题 :4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

专利号:CN-115894141-A
优先权日:2022-10-13
标 题:Synthesis method of acylindene derivatives

专利号:CN-115894141-B
优先权日:2022-10-13
标题:Synthesis method of acylindane derivatives