CAS: 3997-90-8; D-Alanylglycine

相似化合物

687-69-4 28782-78-7 116747-54-7

上下游产品

CAS号34286-66-3 Z-D-丙氨酸-甘氨酸 | CAS号1188-01-8 DL-丙氨酰甘氨酸 | CAS号25413-03-0 Glycine,N-(2-br... | CAS号25413-02-9 ethyl 2-(2-brom... | CAS号687-69-4 L-丙氨酰甘氨酸 | CAS号4526-77-6 环(甘氨酰-L-丙氨酰) | CAS号338-69-2 D-丙氨酸 | CAS号56-41-7 L-丙氨酸

📜(2-溴-丙酰基氨基)-乙酸置于氨体系中,化学反应生成 D-丙氨酰甘氨酸
参考文献:Fischer,E.; Warburg,Justus Liebigs Annalen Der Chemie,1905,Vol. 340,P. 171
标题:Fischer,E.; Warburg,Justus Liebigs Annalen Der Chemie,1905,Vol. 340,P. 171

专利信息

专利号:US-4199500-A
优先权日:1978-11-20
标 题:Peptides related to somatostatin
发明人：SHIELDS JAMES E
权利人:LILLY CO ELI
摘要:The tetradecapaptides of the formula wherein X is H-Ala-D-Ala, H-D-Ala-Gly, or H-D-Val-Gly, or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit the secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.

专利号:US-10577395-B2
优先权日:2014-07-10
标 题 :N-(hydrophobe-substituted) vancosaminyl [Ψ-[C(=NH) NH] Tpg4] vancomycin and [Ψ-[CH2NH]Tpg4] vancomycin
发明人：BOGER DALE L
权利人:SCRIPPS RESEARCH INST
摘要:The total synthesis and evaluation of key analogs of vancomycin containing single atom changes in the binding pocket are disclosed as well as their peripherally modified, N-(hydrophobe-substituted) derivatives exemplified by a N-4-(4′-chlorobiphenyl)-methyl derivative and their pharmaceutically acceptable salts are disclosed. Their evaluation indicates the combined pocket and peripherally modified analogs exhibit a remarkable spectrum of antimicrobial activity and truly impressive potencies against both vancomycin-sensitive and -resistant bacteria, and likely benefit from two independent and synergistic mechanisms of action. A pharmaceutical composition containing a contemplated compound or its pharmaceutically acceptable salt is disclosed, as is a method of treating a bacterial infection in a mammal by administering an antibacterial amount of a contemplated compound or its salt as above to an infected mammal in need of treatment.

专利号:US-5106834-A
优先权日:1988-12-27
标 题 :Linear free-sulfhydryl-containing oligopeptide derivatives as antihypertensive agents
发明人：BOVY PHILIPPE R; MANNING ROBERT E; O'NEAL JOAN M
权利人:SEARLE & CO
摘要:Synthesis and use of novel oligopeptides are described, many of which peptides contain one or several unnatural amino acids. These short linear peptide derivatives are characterized by the presence of a free sulfhydryl function. These compounds have a high affinity for the Atrial Natriuretic Peptide (ANP) receptor coupled to particulate guanylate cyclase. Such peptides are full agonists at the ANP receptor as demonstrated by the ability of the peptides to stimulate the production of cGMP and to relax smooth muscles in vitro. In accord with these observations, the compounds of the invention lower blood pressure in mammals. Preferred peptides are the following: Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-GlyNH2; D-Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-GlyNH2; L-Pen-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-GlyNH2; and Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-IleNH2.

专利号:CN-102241737-B
优先权日:2011-04-06
标 题 :Endomorphin-1 analogs and their synthesis and application in the preparation of analgesic drugs

专利号:CN-102241737-A
优先权日:2011-04-06
标 题:Endomorphin-1 analogs and their synthesis and application in the preparation of analgesic drugs