CAS: 2150-38-1; Methyl 3,4-Dimethoxybenzoate

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diazomethane Veratric acid methanol 4-hydroxy-3-methoxybenzoic acid methyl ester3,4-dimethoxy-(1'-hydroxy-1'-methylethyl)benzene 1-(2,4-dimethoxy-6-methyl-phenyl)-3-(3,4-dimethoxy-phenyl)-propane-1,3-dione isoxazole3-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydrobenzisoxazole 20H27N2O5PC20H27N2O5P

香草酸置于硫酸,Potassium Carbonate体系中,用 丙酮 用作溶剂,化学反应生成3,4-二甲氧基苯甲酸甲酯
参考文献:Benzamides And Benzamidines As Specific Inhibitors Of Epidermal Growth Factor Receptor And V-Src Protein Tyrosine Kinases
标题:Benzamides And Benzamidines As Specific Inhibitors Of Epidermal Growth Factor Receptor And V-Src Protein Tyrosine Kinases
摘要:The Benzamides 1 And The Benzamidines 2 As Well As The Cyclic Benzamidines 3 Were Designed And Synthesized As The Mimics Of 4-Anilinoquinazolines For An Inhibitor Of Egfr Tyrosine Kinase. The Specific Inhibitions Of Egfr Tyrosine Kinase Were Observed In The Benzamides 1C And 1D,And The Benzamidine 2A,Whereas The Specific Inhibitions Of V-Src Kinase Were Observed In The Benzamide 1J And The Benzamidine 2D At A 10 Mug/ml Concentration Of Compounds. The Cyclic Benzamidines 3A And 3B Showed Potent Kinase Inhibition Of Egfr At A 1.0 Mug/ml Concentration. According To The Docking Simulation Using The X-Ray Structure Of Egfr Kinase Domain In Complex With Erlotimb,The Ligscore2 Scoring Function Value Of Erlotimb Was Calculated As 5.61,Whereas That Of The Benzamide 1C Was 5.05. In A Similar Manner,The Ligscore2 Value Of The Cyclic Benzamidine 3A Was Calculated As 5.10. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2004.04.030

专利信息

专利号:US-6258323-B1
优先权日:1998-11-16
标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds
发明人：HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL
权利人:ROHM & HAAS
摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.

专利号:US-7351781-B2
优先权日:2001-04-24
标题 :Synthesis of vinyl polymers by controlled radical polymerization
发明人：WHITE DANIELA; O'DWYER JAMES B
权利人:PPG IND OHIO INC
摘要:A controlled free radical polymerization process, which includes the steps of: adding a monofunctional iniferter compound to an oxygen-free solvent; heating the solution to a temperature sufficient to allow the iniferter compound to form two carbon centered radical residues; adding a first monomer composition comprising one or more monomers to the solution containing the radical containing residues; polymerizing the first monomer composition to form a quasi-living polymer; and optionally polymerizing a second monomer composition comprising one or more monomers, which are different than the first monomer composition. The resulting non-random copolymer having the general formula:n nφ-[-A p -B s -] t -φn nwhere A and B are different compositions of ethylenically unsaturated monomers; p is an integer from 1 to 1,000; s is an integer from 0 to 1,000; t is an integer from 1 to 100; and φ is a residue from the iniferter.

专利号:US-2003018151-A1
优先权日:2001-04-24
标题 :Synthesis of vinyl polymers by controlled radical polymerization

专利号:US-2008039473-A1
优先权日:2006-08-08
标题:Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:The present disclosure is directed to modulators of alpha-adrenergic receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the use of such compounds for the treatment and/or management of hypertension, cardiac failure, prostatitis, and benign prostatic hyperplasia, and any other condition in which it is beneficial to modulate an alpha-adrenergic receptor.

专利号:EP-1381633-A1
优先权日:2001-04-24
标题 :Synthesis of vinyl polymers by controlled radical polymerization

专利号:CN-108144612-A
优先权日:2016-12-02
标 题:A kind of cobalt-based catalyst for one-pot synthesis of carboxylate and its preparation and application