CAS: 172900-69-5; 2-(3-Methoxypropoxy)-4-((R)-2-(Bromomethyl)-3-Methylbutyl)-1-Methoxybenzene

上下游产品

(R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol isovanillin (R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one 4-methoxy-3-(3-methoxypropoxy)benzaldehyde (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine (2R,5S)-2,5-dihydro-3,6-dimethoxy-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine (2R,5S)-2,5-dihydro-3,6-dimethoxy-2-{(2R)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-5-(1-methylethyl)pyrazine (2S)-3,6-diethoxy-2,5-dihydro-2-{(2S)-2-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-3-methylbutyl}-pyrazine

📜异戊酸置于4-二甲氨基吡啶,Sodium Tetrahydroborate,N-溴代丁二酰亚胺(Nbs),Lithium Hydroxide Monohydrate,双氧水,三苯基膦,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,1,1-二氯乙烷,二氯甲烷,水 用作溶剂,化学反应 29.25H,反应生成2-(3-甲氧基丙氧基)-4-((R)-2-(溴甲基)-3-甲基丁基)-1-甲氧基苯
参考文献: Process For The Preparation Of (2S,4S,5S,7S)-N-(2-Carbamyl-2-Methylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]-octanamide Hemifumarate And Its Intermediates Thereof[fr] Procédé Pour Préparer Un Hémifumarate Du Composé (2S,4S,5S,7S)-N-(2-Carbamoyl-2-Méthylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Méthoxy-3-(3-Méthoxypropoxy)Phényl]-octanamide Et Produits Intermédiaires Correspondants
标题: Process For The Preparation Of (2S,4S,5S,7S)-N-(2-Carbamyl-2-Methylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]-octanamide Hemifumarate And Its Intermediates Thereof[fr] Procédé Pour Préparer Un Hémifumarate Du Composé (2S,4S,5S,7S)-N-(2-Carbamoyl-2-Méthylpropyl)-5-Amino-4-Hydroxy-2,7-Diisopropyl-8-[4-Méthoxy-3-(3-Méthoxypropoxy)Phényl]-octanamide Et Produits Intermédiaires Correspondants
摘要:本发明涉及一种制备(2S,4S,5S,7S)-N-(2-羰基-2-甲基丙基)-5-氨基-4-羟基-2,7-二异丙基-8-[4-甲氧基-3-(3-甲氧基丙氧基)苯基]-辛酰胺化合物的方法,其化学式为1,以及其在药学上可接受的盐.此外,涉及制备(R)-4-(2-(卤甲基)-3-甲基丁基)-1-甲氧基-2-(3-甲氧基丙氧基)苯和(R)-2-(4-甲氧基-3-(3-甲氧基丙氧基)苄基)-3-甲基丁醇的方法,这些是化合物1合成中有用的中间体.

专利信息

专利号:WO-2011148392-A1
优先权日:2010-05-28
标题 :Process for the preparation of (2s,4s,5s,7s)-n-(2-carbamyl-2- methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3- methoxypropoxy)phenyl]-octanamide hemifumarate and its intermediates thereof
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
权利人:MSN LAB LTD; SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; VENKAT REDDY GHOJALA; RAMA SUBBA REDDY KARAMALA; SAHADEVA REDDY MARAMREDDY
摘要:The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.

专利号:WO-2012078147-A1
优先权日:2010-12-08
标 题:A process for the preparation of intermediates useful in the production of aliskiren
发明人：BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
权利人:WATSON LAB INC; BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
摘要:A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.

专利号:US-2009281161-A1
优先权日:2006-06-13
标 题:Organic Compounds
发明人：MAIBAUM JUERGEN KLAUS; LORTHIOIS EDWIGE LILIANE JEANNE
权利人:MAIBAUM JUERGEN KLAUS; LORTHIOIS EDWIGE LILIANE JEANNE
摘要:Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I) wherein the substituents are as described in the specification.

专利号:US-2009270417-A1
优先权日:2006-06-13
标 题:Organic Compounds
发明人：MAIBAUM JUERGEN KLAUS; LORTHIOIS EDWIGE LILIANE JEANNE; BUEHIMAYER PETER
权利人:NOVARTIS AG
摘要:Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula (I) wherein the substituents are as described in the specification.