CAS: 17013-01-3; Fumaric Acid Disodium Salt

该化合物是一种化学化合物,具有两种离子钠和抗腐蚀阴离子的特征,是一种作为烟酸钠盐的化合物,通常被作为一种白色晶状粉,在水中溶解,可提高其在各种应用中的效用;该化合物在生物化学中,特别是在代谢途径中的作用众所周知,因为泡沫是柠檬酸循环的中间体;二钠泡沫经常在食品和制药工业中用作食物添加剂和潜在的治疗剂,因其抗氧化特性,它也可能表现出缓冲能力,使其在需要pH稳定的配方中有用;此外,还研究了二钠泡沫酸盐在治疗某些医疗条件方面的潜在好处,包括:包括:线虫病和多发性硬化症,因为其免疫性液效应.

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相似化合物

371-47-1 141-01-5 110-16-7

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上下游产品

CAS号110-17-8 富马酸,反丁烯二酸 | CAS号3105-55-3 顺丁烯二酸单钠盐三水合物 | CAS号121-75-5 马拉硫磷 | CAS号97-67-6 L-苹果酸 | CAS号621-14-7 琥珀酸二苯酯

合成工艺路线路线简述

  • 合成目标产物 Disodium Fumarate 主要起始原料 Fumaric Acid
  • (文献来源)合成步骤主要原料 Fumaric Acid

海关参考信息

专利信息


专利号:US-12263464-B2
优先权日:2018-03-14
标题 :Method for in-situ synthesis of metal organic frameworks (MOFs), covalent organic frameworks (COFs) and zeolite imidazolate frameworks (ZIFs), and applications thereof
发明人:PAHWA DEEPAK; PAHWA VARUN; CHOUDHARY ANIL KUMAR; SONIA; JHA VIVEK KUMAR; CHAUHAN ANJALI; YADAV ANNU
权利人:DESICCANT ROTORS INTERNATIONAL PRIVATE LTD
摘要:The present invention relates to a method for the in situ synthesis of of MOFs (metal organic frameworks), COFs (covalent organic frameworks), and ZIFs (Zeolitic imidazolate framework), onto and within different types of porous substrates, and their applications. The present invention provides a unique and easy to utilize method by which a number of MOFs, COFs and ZIFs can be synthesized directly onto and within a porous substrate with high performance efficiency ensuring higher grammage in formation of adsorbent product onto and within the substrate.

专利号:US-5788950-A
优先权日:1994-08-03
标 题 :Method for the synthesis of mixed metal oxide powders
发明人:IMAMURA KUNIO; DIGREGORIO JOHN F; SMITH DOUGLAS M; IZAWA HIROZUMI; YAMAGUCHI TETSUHIKO
权利人:SHOWA DENKO KK
摘要:A technique to synthesize complex oxide ceramic powders which offers advantages of both the coprecipitation and sol-gel routes while doing away with the disadvantages is disclosed. Namely, the ability to achieve chemical homogeneity and crystallite size on the namometer length scale at a nonprohibitive cost is provided by the disclosed method. In one embodiment of the invention, a method for the synthesis of a mixed metal oxide powder is provided including (a) combining a liquid absorbent resin with at least one solution selected from the group consisting of solutions containing at least one organo-metallic compound and solutions containing at least one metallic salt compound, such that at least two metals are present in the liquid absorbent resin after the combining is completed; (b) after the combining, allowing the liquid absorbent resin to swell and gel and thereby form a swollen gel; (c) preparing a precursor material by changing at least one of the pH and temperature of the swollen gel; (d) pyrolyzing the precursor material to form a pyrolyzed precursor material; and (e) calcining the pyrolyzed precursor material to form a mixed metal oxide powder.

专利号:US-2004053355-A1
优先权日:2000-05-26
标题:Modular approach to on-line synthesis, drug discovery and biochemical transformations using immobilized enzyme reactors
发明人:WAINER IRVING; MARKOGLOU NEKTARIA
摘要:A coupled system using extremely different enzymes with incompatible cofactors and reaction conditions has been constructed using standard liquid chromatographic formats and open tubular formats. One of the significant aspects of the present invention lies in the development of the liquid chromatographic on-line enzyme cascade. This has been illustrated by the biosynthetic pathway involving dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase which encompass the synthesis of the key neurotransmitters, norepinephrine and epinephrine. The results demonstrate for the first time the immobilization of dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. The IMERs are active and can be used in a liquid chromatographic format for qualitative and quantitative determinations. The IMER-HPLC system can be used to carry out standard Michaelis-Menten enzyme kinetic studies and to quantitatively determine enzyme kinetic constants, identify specific enzyme inhibitors, provide information regarding the mode of inhibition and the inhibitor constants (K i ). A second significant aspect of the present invention lies in the ability of the immobilized enzyme reactors to be used independently or as a combination, thus providing a unique opportunity to explore the interrelationships between these enzymes, to investigate the source of diseases and to design new drug entities for identified clinical syndromes.

专利号:EP-0193420-B1
优先权日:1985-01-18
标题 :Device for the determination of compounds having an influence on the cellular oxidation pathway and methods for the determination of these compounds
摘要:1. Device for the specific assay of substrates, inhibitors, or activators of the cellular oxidation chain, characterized in that it contains an oxygen sensor, associated with means for measuring the oxygen detected, and the transporting species of the cellular respiratory chain in the form of immobilized bacteria, of immobilized microorganisms or of their immobilized membrane preparations, these cells having been cultured beforehand on a medium whose composition has produced a modification of the cellular synthesis of the flavoprotein corresponding to the compound to be assayed.

专利号:US-5536843-A
优先权日:1992-02-12
标题 :Synthesis of indoles by dehydrogenation of indolines
发明人:KNUEBEL GEORG; MICHEL ROSWITHA; ROSE DAVID
权利人:HENKEL KGAA
摘要:##STR1## By dehydrating indolines or their salts, the corresponding indoles having formula (I) are obtained. In the formula, R 1 and R 3 represent independently from each other hydrogen or alkyl groups with 1 to 4 C atoms, R 2 stands for hydrogen, a methyl or a carboxyl group, R 4 and R 5 represent independently from each other hydrogen, amino groups, hydroxy groups, alkyl groups with 1 to 4 C atoms or alkoxy groups with 1 to 4 C atoms, or, in case R 4 and R 5 are bound to adjacent C atoms, both residues may also represent together an alkylene dioxy group with 1 to 4 C atoms. This process allows high yields of very pure indoles to be produced.

专利号:US-8183409-B2
优先权日:2004-05-06
标题:High yield and rapid synthesis methods for producing metallo-organic salts
发明人:CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.
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主要参考文献

[参考文献]: Chandresh Thakker, Et Al. Use Of Transposase And Ends Of Is608 Enables Precise And Scarless Genome Modification For Modulating Gene Expression And Metabolic Engineering Applications In Escherichia Coli. Biotechnol J. 2016 Jan;11(1):80-90.
[参考文献]: Jennifer Haggarty, Et Al. Serially Coupling Hydrophobic Interaction And Reversed-Phase Chromatography With Simultaneous Gradients Provides Greater Coverage Of The Metabolome. Metabolomics. 2015;11(5):1465-1470.

合成参考文献


摘要:Journal of the American Pharmaceutical Association, Scientific Edition., 31(12), 1942
摘要:Final Report 3/2009 Available from CIR
参考文献:10.1007/bf02787377
摘要:Rydzewska G, Jurkowska G, Gabryelewicz A. The influence of acute ethanol ingestion on phospholipase D activity in rat pancreas. An in vitro and in vivo study. Int J Pancreatol. 1996 Aug;20(1):59–68. doi: 10.1007/bf02787377.
参考文献:10.1385/abab:78:1-3:511
摘要:Ryu H, Kang K, Yun J. Bioconversion of fumarate to succinate using glycerol as a carbon source. Applied Biochemistry and Biotechnology. 1999 Mar;78(1-3):511–20. doi: 10.1385/abab:78:1-3:511.
参考文献:10.1385/abab:91-93:1-9:525
摘要:Ryu H, Wee Y. Characterization of bioconversion of fumarate to succinate by alginate immobilized Enterococcus faecalis RKY1. Applied Biochemistry and Biotechnology. 2001 Mar;91-93(1-9):525–35. doi: 10.1385/abab:91-93:1-9:525.
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