CAS: 1629-58-9; Ethyl Vinyl Ketone

上下游产品

1-chloro-3-pentanone 3,4,5-pentanetriol 1-penten 1-Penten-3-olethyl-4-(4'-methyl-3'-pentenyl)-3-cyclohexenyl ketone 2,3,4,4a,9,10-hexahydro-7-methoxy-1,4aβ-dimethyl-2-phenanthrone 15,15'-didehydro-β,β-caroten-4-one 2-pyrazolin3-Ethyl-Δ2-pyrazolin

1-戊烯-3-醇置于戴斯-马丁氧化剂体系中,用 二氯甲烷 用作溶剂,化学反应 4.0H,以67%的收率获得1-戊烯-3-酮
参考文献:(+)-异隐丹参酮衍生物及其简化的类似物作为 Stat3 信号通路抑制剂
标题:(+)-异隐丹参酮衍生物及其简化的类似物作为 Stat3 信号通路抑制剂
摘要:异隐丹参酮 (Icts) 是一种天然产物,具有潜在的信号转导和转录激活剂 3 (Stat3) 信号通路抑制活性,对多种肿瘤具有显着的抑制活性.在这项研究中,设计,合成和评估了一系列含有 1,4-萘醌核心的 Icts 衍生物和简化的类似物.结果表明,大多数目标化合物是有效的 Stat3 信号通路抑制剂,基于其抑制 Stat3 磷酸化的机制.此外,基于获得的数据,结构-活性关系(sar)被合理推导.同时,化合物16R的分子对接建议其与 Stat3 的可能交互模式.为了进一步验证抗癌活性,使用 Hct116,Hepg 2,Mcf-7,A549 和 U251 细胞系测试了所有目标化合物.有趣的是,与不同的肿瘤细胞系相比,Hct-116 细胞系被确定为最敏感.此外,化合物21E,16R,28A和16E显示出对 Hct116 细胞生长的剂量依赖性抑制.因此,确定了 Icts 衍生物及其简化类似物的
Doi:10.1016/j.Bioorg.2022.106015

专利信息

专利号:US-11926589-B2
优先权日:2019-07-09
标 题 :Process for the synthesis of non-racemic cyclohexenes
发明人：REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND
权利人:BASF CORP; CALIFORNIA INST OF TECHN
摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.

专利号:US-6794534-B2
优先权日:2000-06-23
标题:Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; MORGAN JOHN P; SCHOLL MATTHIAS; CHOI TAE-LIM
权利人:CALIFORNIA INST OF TECHN
摘要:The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of α-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are each independently an anionic ligand; n L is a neutral electron donor ligand; and, n R, R 1 R 6 , R 7 , R 8 , and R 9 are each independently hydrogen or a substituent selected from the group consisting of C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl.

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

专利号:US-2007293706-A1
优先权日:2004-11-01
标 题:Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones
发明人：WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
权利人:WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
摘要:1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones are useful as estrogen receptor modulators and as precursors to estrogen receptor modulators. The current invention provides a method for the synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones from simple indanone starting materials via a Robinson-type annulation followed by an internal alkylation reaction. This invention further describes the novel use of a fluoroethyl substituent as a latent alkylating group for an internal cyclization reaction.

专利号:US-4110380-A
优先权日:1974-05-06
标题 :Asymmetric synthesis of organic compounds
发明人：HAJOS ZOLTAN GEORGE; PARRISH DAVID RICHARD
权利人:HOFFMANN LA ROCHE
摘要:Optically active organic compounds are prepared starting from optically inactive reactants by means of an optically active agent which influences the course of the reaction. In particular optically active compounds having a 'meso' type carbon atom undergo an intramolecular ring closure in the presence of an optically active agent to yield an optically active product having one additional ring. The present process is particularly useful in the preparation of optically active bicyclic diketones which are important intermediates in the total synthesis of steroids.

专利号:US-3825569-A
优先权日:1967-12-04
标题 :Synthesis of tricyclic carbocyclic compounds and intermediates therefor
发明人：HAJOS Z; OLIVETO E
权利人:HOFFMANN LA ROCHE
摘要:METHODS FOR THE PREPARATION OF 2,3,3A,4,5,7,8,9,9AB,9BADECAHYDRO - 3AB-PRIMARY LOWER ALKYL-7-OXO-1H-BENZ(E) INDENES AND 4,4AB,4BA,5,6,7,8,8A,9,10-DECAHYDRO-8AB-PRIMARY LOWER ALKYL - 3H-PHENANTHREN-2-ONES BY CYCLIZING COMPOUNDS OF THE FORMULA WHERE R1 IS HYDROGEN OR LOWER ALKYL; Z'' IS CARBONYL OR CH(OR2''); R2'' IS HYDROGEN, LOWER AKYL, LOWER ALKANOYL, BENZOYL, NITROBENZOYL, CARBOXY-LOWER ALKANOYL, CARBOXYBENZOYL, TRIFLUOROACETYL OR CAMPHORSULFONYL; T'' IS -C(X'')=CH-, -C(OR3)=CH- OR -Q''-CH2-; R3 IS LOWER ALKYL; X'' IS BROMINE, CHLORINE OR IODINE; Q'' IS CARBONYL, LOWER ALKYLENE DIOXY-METHYLENE, DI-(LOWER ALKOXY)-METHYLENE OR HYDROXY-METHYLENE, R4 IS LOWER PRIMARY ALKYL AND M IS AN INTEGER HAVING A VALUE OF 1 OR 2. THE COMPOUNDS OF THIS SERIES ARE USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF KNOWN STEROIDS WHICH ARE PHARMACOLOGICALLY ACTIVE AS FERTILITY CONTROL AGENTS. CH3)-) R1-CH2-T''-CH2-CH(-CO-H)-CH<(-CH2-(CH2)M-Z''-C(-R4)(-CH2-