CAS: 1623-88-7; 5-(Chloromethyl)Furan-2-Carbaldehyde

相似化合物

2144-37-8 2528-00-9 10375-34-5

上下游产品

5-羟甲基糠醛 5-Hydroxymethyl-2-Furfuraldehyde 67-47-0

2,3,4,5,6-Pentahydroxy-Hexanal置于aluminium(III) Chloride Hexahydrate,氯化胆碱,草酸体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 0.5H,以70.2%的收率获得5-氯甲基呋喃-2-甲醛
参考文献:一种5-卤代甲基糠醛的制备方法
标题:一种5-卤代甲基糠醛的制备方法
摘要:本发明公开了一种5‑卤代甲基糠醛的制备方法,包括如下步骤:(1)将原料,氯化胆碱/溴化胆碱,作为氢键供体的有机酸,金属盐和二氯乙烷加入反应器中,于80‑150oc搅拌反应5‑300Min,获得由上层和下层组成的反应相,该下层为低共熔溶剂相,该上层为二氯乙烷相;(2)将上述低共熔溶剂相经二氯乙烷萃取和分离纯化,获得含有5‑卤代甲基糠醛的产物.本发明选用的原料来源更加广泛,廉价易得;反应条件温和,反应产率高;为今后5‑卤代甲基糠醛及其下游产物研究提供了一种新颖的思路.

专利信息

专利号:US-2024059701-A1
优先权日:2021-04-22
标 题 :Methods for Synthesis of an Advantageous N-Heterocyclic Carbene Catalyst
发明人：CAHANA AVIAD; FARONE WILLIAM A
权利人:XF TECH INC
摘要:The present invention concerns the synthesis of the salts of a Triazolium N-Heterocyclic Carbene (NHC) catalyst in various salt forms prepared from 2-methylaniline, 2-methylphenylhydrazine hydrochloride or 2-methylphenylhydrazine. The molecules so prepared are useful in catalysis of carbene reactions and are advantageous due to their lack of chlorinated or fluorinated intermediates and lack of chlorine or fluorine in the final structure.

专利号:US-11136302-B2
优先权日:2017-05-26
标 题:Single step process for the synthesis of furan derivatives from carbohydrates
发明人：RODE CHANDRASHEKHAR VASANT; SHINDE SUHAS HANMANT
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a single step process for the synthesis of furan derivative from carbohydrate comprises stirring the reaction mixture of carbohydrate in solvent in presence of catalyst at temperature in the range of 170 to 190° C. for the period in the range of 23 to 25 hrs to afford corresponding furan derivative.

专利号:US-9783517-B2
优先权日:2010-08-19
标题 :Method for synthesis of an output including diesters of 5-methyl-2-furoic acid
发明人：CAHANA AVIAD; MARTIN TIM
权利人:CAHANA AVIAD; MARTIN TIM; XF TECH INC
摘要:The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).

专利号:US-2025084070-A1
优先权日:2021-12-21
标题:Process for the synthesis of 5-((2-methyl-1h-imidazol-1-yl)methyl)furan-2-carbaldehyde and of nitrones from 5-((2-methyl-1h-imidazol-1-yl)methyl)furan-2-carbaldehyde
发明人：JEAN-BAPTISTE-DIT-DOMINIQUE FRANCOIS; SUTTER MARC; IVANOV SERGEY; NGO ROBERT; MARTY LUANA
权利人:MICHELIN & CIE
摘要:A process for synthesizing 5-((2-methyl-1H-imidazol-1-yl)methyl)furan-2-carbaldehyde from a mixture comprising a carbohydrate, an alkali or alkaline-earth metal chloride, hydrochloric acid, water, an organic solvent, namely a water-insoluble polar aprotic solvent, and optionally a phase-transfer agent, proceeds via the formation of 5-(chloromethyl)furan-2-carbaldehyde, without isolating this synthesis intermediate. A process also synthesizes a compound of formula (III) below:from 5-((2-methyl-1H-imidazol-1-yl)methyl)furan-2-carbaldehyde.

专利号:US-2025171411-A1
优先权日:2022-03-01
标题:Synthesis of 5-acetoxymethyl furfural in the presence of recyclable salt catalysts
发明人：MELLER ELAD; LEADER AVIA
权利人:CELLUFLUX LTD
摘要:A process for preparing and ester of 5-hydroxymethyl furfural of the formula: (I) wherein R is a linear or branched alkyl or alkenyl, comprising adding to a reaction vessel Ce carbohydrate, organic acid R—COOH and a salt which is at most sparingly soluble in said organic acid to form a reaction mass, heating the reaction mass, allowing the reaction to proceed, separating the salt from the liquid phase and recovering a reaction product comprising an ester of 5-hydroxymethyl furfural.

专利号:US-9102644-B2
优先权日:2012-10-16
标 题 :Efficient, high-yield conversion of saccharides in a pure or crude form to 5-(chloromethyl)-2-furaldehyde
发明人：MIKOCHIK PETER; CAHANA AVIAD; NIKITIN EDWARD; STANDIFORD JEREMY; ELLIS KYLE; ZHANG LUZHENG; GEORGE TIMOTHY
权利人:MIKOCHIK PETER; CAHANA AVIAD; NIKITIN EDWARD; STANDIFORD JEREMY; ELLIS KYLE; ZHANG LUZHENG; GEORGE TIMOTHY; XF TECHNOLOGIES INC
摘要:The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).