CAS: 149771-09-5; Ethyl 2-Amino-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate

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187035-81-0 863774-22-5 149771-23-3

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CAS号187035-79-6 2-氯-4-三氟甲基-嘧啶-甲酸乙酯 | CAS号593-87-3 乙酸胍 | CAS号1048670-08-1 ethyl 2-(ethoxy... | CAS号372-31-6 三氟乙酰乙酸乙酯 | CAS号154934-97-1 2-羟基-4-三氟甲基-5-嘧啶甲酸乙酯 | CAS号149771-23-3 2-氨基-4-三氟甲基嘧啶-5-甲酸 | CAS号16075-42-6 2-氨基-4-(三氟甲基)嘧啶

📜2-羟基-4-三氟甲基嘧啶-5-羧酸乙酯置于氨,三氯氧磷体系中,用 四氢呋喃 用作溶剂,化学反应 9.0H,反应生成2-氨基-4-三氟甲基嘧啶-5-羧酸乙酯
参考文献:Structure-activity Relationship Studies Of Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))Amino]-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate: An Inhibitor Of Ap-1 And Nf-κb Mediated Gene Expression
标题:Structure-activity Relationship Studies Of Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))Amino]-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate: An Inhibitor Of Ap-1 And Nf-κb Mediated Gene Expression
摘要:Several Analogues Of Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))Amino]-4-(Trifluoromethyl)Pyrimidine-5-Carboxylate (1) Were Synthesized And Tested As Inhibitors Of Ap-1 And Nf-Kappab Mediated Transcriptional Activation In Jurkat T Cells. From Our Sar Work,Ethyl 2-[(3-Methyl-2,5-Dioxo(3-Pyrrolinyl))-N-Methylamino]-4-(Trifluoromethyl)-Pyrimidine-5-Carboxylate Was Identified As A Novel And Potent Inhibitor. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(02)00517-6