CAS: 1496551-65-5; ((2R,3R,4R)-3-(Benzoyloxy)-4-Chloro-4-Methyl-5-Oxotetrahydrofuran-2-yl)Methyl Benzoate
- 英文名称((2R,3R,4R)-3-(Benzoyloxy)-4-Chloro-4-Methyl-5-Oxotetrahydrofuran-2-yl)Methyl Benzoate
- 中文名称((2R,3R,4R)-3-(苯甲酰氧基)-4-氯-4-甲基-5-氧代四氢呋喃-2-基)甲基苯甲酸甲酯
- IUPAC名称((2R,3R,4R)-3-(benzoyloxy)-4-chloro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
- 其它别名索福斯布韦杂质o; Ywklgxfchylfer-Jxxfodfxsa-N
- CAS编号1496551-65-5
- MFCD编号:MFCD23380738
- FDA UNII编号:38J9GW8QLY
- 分子式:C20H17ClO6分子量:388.8
- 产品CID: 722248
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
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海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
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专利信息
专利号:US-9376410-B2
优先权日:2012-10-10
标题 :(2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone and preparation method and use thereof
发明人：WANG GUAN; JIANG XIANGRUI; GONG XUDONG; CHEN WEIMING; ZHU FUQIANG; ZHANG RONGXIA; ZHAO XIANGUO
权利人:TOPHARMAN SHANGHAI CO LTD; SHANGHAI INST MATERIA MEDICA; TOPHARMAN SHANDONG CO LTD; SHANGHAI INST MATERIA MEDICA
摘要:This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application.
