CAS: 144256-11-1; (S)-(2,2-Dimethyl-1,3-Dioxolan-4-yl)Methyl 3-(4-Hydroxyphenyl)Propanoate

英文名称(S)-(2,2-Dimethyl-1,3-Dioxolan-4-yl)Methyl 3-(4-Hydroxyphenyl)Propanoate
中文名称(S)-(2,2-二甲基-1,3-二氧环戊烷-4-基)甲基3-(4-羟基苯基)丙酸酯
IUPAC名称(S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-hydroxyphenyl)propanoate
其它别名(4S)-(2,2-Dimethyl-1,3-Dioxolan-4-yl)-3-(4- Hydroxybenzene) Propanoic Acid,Methyl Ester (Landiolol); ((S)-2,2-Dimethyl-1,3-Dioxolan-4-yl)Methyl 3-(4-Hydroxyphenyl)Propanoate; Benzenepropanoic Acid, 4-Hydroxy-, [(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]Methyl Ester; 4-Hydroxybenzenepropanoic Acid [(4S)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]Methyl Ester; 4S)-(2,2-Dimethyl-1,3-Dioxolan-4-yl)-3-(4-Hydroxybenzene) Propanoicacid,Methyl Ester; Landiolol Hclpi-1; 4-Hydroxybenzenepropanoic Acid [(4S)-2,2-Dimethyl-1,3; 3-(4-Hydroxyphenyl)Propanoic Acid (2,2-Dimethyl-1,3-Dioxolan-4-yl)Methyl Ester
CAS编号144256-11-1
MFCD编号:MFCD11045071
EINECS号:689-773-9
FDA UNII编号:MM5EF9L9HQ
分子式:C15H20O5
分子量:280.32
产品CID: 671926
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: TWMFOGUTFPLVQZ-CYBMUJFWSA-N
InChI=1S/C15H20O5/c1-15(2)19-10-13(20-15)9-18-14(17)8-5-11-3-6-12(16)7-4-11/h3-4,6-7,13,16H,5,8-10H2,1-2H3/t13-/m1/s1…
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数5.0

相似化合物

222555-06-8 23795-02-0 2180628-04-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P302+P352

上下游产品

4-hydroxyphenylpropionic acid (S)-1-O-tosyl-2,3-O-isopropylideneglycerol (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate phenyl>propionate2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-4-2(S),3-epoxypropoxyphenylpropionate -2S-hydroxypropoxy>phenyl>propionate2,2-dimethyl-1,3-dioxolan-4S-ylmethyl 3-4-3-2-(morpholin°Carbonylamino)ethylamino-2S-hydroxypropoxyphenylpropionate Landiolol hydr°Chloride landiolol hydr°Chloride

合成工艺路线路线简述

对羟基苯丙酸,对甲苯磺酸(S)-(-)-2,2-二甲基-1,3-二氧戊环基-4-基甲基酯置于氢氧化钾体系中,用二甲基亚砜用作溶剂,化学反应 1.0H,以98%的收率获得(S)-(2,2-二甲基-1,3-二氧环戊烷-4-基)甲基 3-(4-羟基苯基)丙酸酯
参考文献:Development Of A Highly Cardioselective Ultra Short-Acting .Beta.-Blocker,Ono-1101.
标题:Development Of A Highly Cardioselective Ultra Short-Acting .Beta.-Blocker,Ono-1101.
摘要:一种新型,高度心脏选择性超短效β受体阻滞剂ono-1101已研发成功,可用于心动过速的紧急治疗和手术中更好地控制心率.该药物在体内的β受体阻断活性比艾司洛尔强约9倍,在体外的心脏选择性比艾司洛尔强8倍.这种β受体阻断药物的作用时间短,如果出现副作用,停药后即可迅速恢复.它可安全用于急性心脏病患者,是心脏病治疗领域的一大进步.
Doi:10.1248/cpb.40.1462

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-2687521-B1
优先权日:2012-07-20
标题 :'Process for the enantioselective synthesis of landiolol'
发明人：GARAVAGLIA FABIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA

专利号:EP-2687521-A1
优先权日:2012-07-20
标题:'Process for the enantioselective synthesis of landiolol'

专利号:JP-2012184229-A
优先权日:2011-03-04
标题:Process for enantioselective synthesis of landiolol

专利号:ES-2532851-T3
优先权日:2012-07-20
标题:Process for enantioselective synthesis of landiolol