CAS: 144189-66-2; 3-Nitrosobenzamide

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3-氨基苯甲酰胺 3-Aminobenzamide 3544-24-9

合成工艺路线路线简述

    📜3-氨基苯甲酰胺置于m-Chloroperoxybenzoic Acid体系中,用 乙酸乙酯 用作溶剂,以34%的收率获得3-亚硝基苯酰胺
    参考文献:Specific Inactivators Of "Retroviral" (Asymmetric) Zinc Fingers
    标题:Specific Inactivators Of "Retroviral" (Asymmetric) Zinc Fingers
    摘要:本发明提供了用于灭活病毒的新型化合物.这些化合物包括6-亚硝基-1,2-苯并吡喃酮,3-亚硝基苯甲酰胺,5-亚硝基-1(2H)异喹啉酮,7-亚硝基-1(2H)-异喹啉酮,8-亚硝基-1(2H)-异喹啉酮.本发明还提供了含有一种或多种该化合物的组合物,以及使用该化合物和组合物治疗病毒感染,癌症,感染性病毒浓度的方法.

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    专利信息


    专利号:WO-0063152-A1
    优先权日:1999-02-22
    标题:Acetylated and related analogues of chicoric acid as hiv integrase inhibitors
    发明人:BURKE TERRENCE R; ZHAIWEI LIN; ZHAO HE; NEAMATI NOURI; POMMIER YVES
    权利人:US HEALTH; BURKE TERRENCE R; ZHAIWEI LIN; ZHAO HE; NEAMATI NOURI; POMMIER YVES
    摘要:Chicoric acid analogues and derivatives have activity against HIV-1 integrase. The structural features that are required for this activity are elucidated by assaying these analogues and derivatives against HIV-1 integrase. Furthermore, methods of synthesis of the enantiomers of chicoric acid itself, as well as its analogues and derivatives, are disclosed. Additionally, methods of use of chicoric acid analogues and derivatives to inhibit HIV-1 integrase are disclosed, as are compositions comprising chicoric acid analogues and derivatives.

    专利号:WO-2014063189-A1
    优先权日:2012-10-23
    标题 :Methods and products for preventing and/or treating a stress induced cardiomyopathy
    发明人:HOROWITZ JOHN; CHIRKOV YULIY
    权利人:ADELAIDE RES & INNOVATION PTY
    摘要:The present disclosure relates to methods and products for preventing and/or treating a stress- induced cardiomyopathy. Certain embodiments of the present disclosure provide a method of preventing and/or treating a stress-induced cardiomyopathy in a subject, the method comprising administering to the subject a therapeutically effective amount of one or more of the following agents: a peroxynitrite inhibitor; an inhibitor of peroxynitrite synthesis; an inhibitor of peroxynitrite associated signalling; an inhibitor of peroxynitrite-induced DNA damage; a Tx NIP inhibitor; a beta 2 adrenoceptor antagonist; and a beta 3 adrenoceptor antagonist; thereby preventing and/or treating the stress-induced cardiomyopathy in the subject.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.2478/s11532-006-0040-2
    摘要:Florian M, Cîrcu M, Toupet L, Terec A, Grosu I, Ramondenc Y, Dincă N, Plé G. Synthesis and stereochemistry of some new 1,3,5-tris(1,3-dioxan-2-yl)-benzene derivatives. 2006 Dec 01;4(4):808–21. doi: 10.2478/s11532-006-0040-2.
    参考文献:10.1021/jm9708543
    摘要:Huang M, Maynard A, Turpin JA, Graham L, Janini GM, Covell DG, Rice WG. Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins. J Med Chem. 1998 Apr 23;41(9):1371–81. doi: 10.1021/jm9708543.
    参考文献:10.1038/nchembio.418
    摘要:Noguchi A, Kitamura T, Onaka H, Horinouchi S, Ohnishi Y. A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis. Nat Chem Biol. 2010 Sep;6(9):641–3. doi: 10.1038/nchembio.418.
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