CAS: 13623-94-4; 1,1-Bis(Methylthio)-2-Nitroethylene

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CAS号25963-52-4 1,1-Ethenedithi... | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号75-15-0 二硫化碳 | CAS号75-52-5 硝基甲烷 | CAS号105828-97-5 2-chloro-5-[[(2... | CAS号24998-80-9 2-(nitromethyl)... | CAS号66357-35-5 雷尼替丁 | CAS号102266-15-9 2-氨基-3-硝基-6-苯基吡啶 | CAS号101336-63-4 2-chloro-5-[[(2... | CAS号112233-23-5 5,6-二氢-3-(甲基氨基)... | CAS号13624-01-6 N-(1-methylsulf... | CAS号121563-96-0 N-(1-methylsulf... | CAS号71090-35-2 2-硝基乙烯-1,1-二胺 | CAS号717852-01-2 5-Pyrimidinol, ...

Potassium;2-Nitroethene-1,1-Dithiol 反应生成1,1-双(甲硫基)-2-亚硝基乙烯
参考文献:尼扎替丁注射剂及其制备方法
标题:尼扎替丁注射剂及其制备方法
摘要:本发明提供了一种尼扎替丁注射剂及其制备方法,所述的尼扎替丁的合成包括:2－二甲胺基甲基－4－氯甲基噻唑盐酸盐的制备;N－(2－巯乙基)－n'－甲基－2－硝基－1,1乙烯二胺的制备;尼扎替丁的合成.三个步骤;所述注射液规格优选为4Ml∶100Mg;于25oc以下,避光贮存.本发明产品制剂处方组成合理,制备工艺适合工业化生产,产品质量稳定,药品标准可控制产品质量;临床应用安全.

专利信息

专利号:US-4532322-A
优先权日:1983-05-23
标题:Preparation of thiazine derivatives
发明人：JACKSON ARTHUR; HEYES GRAHAM
权利人:FINE ORGANICS LTD
摘要:A method for the preparation of a thiazine derivative of the formula ##STR1## where each R is independently selected from hydrogen or a lower alkyl having 1 to 4 carbon atoms, the method comprising reacting together a sulphur donor which is selected from sulfur, ammonium or alkali metal sulfides, ammonium or alkali metal hydrosulfides, or hydrogen sulfide, 1,1-bis(methylthio)-2-nitroethene and a compound of the formula n n H.sub.2 NCR.sub.2 CR.sub.2 CR.sub.2 OSO.sub.3 H n n where each R is as defined above. n A preferred method is for the preparation of tetra-2-(nitromethylene)-2H-1,3-thiazine which possesses broad spectrum insecticidal activity, and is also useful as an intermediate in the synthesis of other insecticides.

专利号:US-4967007-A
优先权日:1989-05-10
标 题 :Improved process for the preparation of 1-substituted amino-1-substituted thio-2-nitro alkenes
发明人：DESHMUKH ABDUL R A S; BHAWAL BABURAO M; SHIRALKAR VASUDEO P; RAJAPPA SRINIVASACHARI
权利人:COUNCIL SCIENT IND RES
摘要:A process is disclosed for the manufacture of 1-substituted amino-1-substituted thio-2 nitro alkenes of the general formula: (R1NH) (R2S) Câ•?CR3 (NO2) wherein R1, R2, R3, may be same or different and may consist of hydrogen, alkyl, aryl or arylalkyl groups or combinations thereof. These alkenes are prepared by reacting a primary amine with a compound of sulfur in the presence of a primary catalyst to obtain a carbonimidodithioic acid salt which is converted to a corresponding ester which is thereafter reacted with a nitro compound in the presence of a secondary catalyst. 1-methylamino-1-methylthio-2-nitroethene is an important intermediate in the synthesis of Rantitidine and Nizatidine which are used as effective drugs in the treatment of peptic ulcers and associated gastrointestinal disorders.

专利号:RU-2042671-C1
优先权日:1990-11-09
标 题:Diketoneimine derivative as an intermediate product for synthesis of ranitidine and method of its synthesis

专利号:WO-0029400-A2
优先权日:1998-11-19
标 题 :Procedure for synthesis of n-[2[[[5- [(dialkilamino) methyl]-2- furanyl] methyl]thyo] ethyl]-n'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides

专利号:EP-0486461-B1
优先权日:1990-11-09
标 题:A diketene imine derivative and process for preparing same
发明人：JESZENSKI ANDOR DIPL-CHEM; LOSONCZI BELA DR DIPL-CHEM; CZEH MARIA; GODO LASZLO; STEFKO BELA DR; BENCZIK TAMAS DIPL-CHEM ING; HERMANN LAZSLO DIPL-CHEM ING; HAVASI GABOR DIPL-CHEM ING; KALVIN PETER DIPL-CHEM ING; STEFAN LASZLO DIPL-CHEM ING; MEGYERI GABOR DR DIPL-CHEM ING
权利人:RICHTER GEDEON VEGYESZET
摘要:The invention relates to the novel compound of formula (I), chemically 1-{2-[(5-N,N-dimethylaminomethyl-2-furyl)-methylthio]ethyl}-2-{2-[(5-N ,N-dimethylaminomethyl-2-furyl)-methylthio]-1-ethylamino} -3-nitro-4-nitromethylene-2-azetine, which is a useful key intermediate in the synthesis of 1-{2-[(5-dimethylaminomethyl-2-furyl)methylthio]ethyl}-amino-1-methyla mino-2-nitroethylene (generic name: ranitidine), a known H-2 receptor antagonist. The invention further relates to a process for the preparation of the compound of formula (I), which can be carried out in one simple process step on industrial scale, too. The compound of formula (I) can easily be transformed to ranitidine in one simple step.

专利号:US-4777260-A
优先权日:1985-12-18
标题 :Synthesis of nizatidine intermediate
发明人：RYAN CHARLES W; SLOMSKI BRUCE A
权利人:LILLY CO ELI
摘要:The present invention provides a process for preparing a novel intermediate for nizatidine.